Immune Activation and Neurodegeneration in HIV Infection and Heavy Drinking

HIV 感染和酗酒中的免疫激活和神经变性

• 批准号: 10373467
• 负责人: Mollie A Monnig
• 金额: $ 12.76万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373467
• 关键词: 3 year old; 3-Dimensional; Acquired Immunodeficiency Syndrome; Acute; Administrative Supplement; Alcohol consumption; Alcoholic beverage heavy drinker; Alcohols; Behavioral; Biological Assay; Biological Markers; Blood; Blood - brain barrier anatomy; Blood Circulation; Brain; CD4 Lymphocyte Count; COVID-19; COVID-19 pandemic; Caring; Cells; Characteristics; Child; Chronic; Clinical; Clinical Investigator; Clinical Research; Collaborations; Collection; Contracts; Control Groups; Data; Data Analyses; Data Collection; Dose; Employment; Environment; Family; Fiber; Functional disorder; Funding; Goals; Guidelines; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; Heavy Drinking; Home; Image; Immune; Immune response; Immune system; Immunologic Markers; Immunology procedure; Individual; Infiltration; Inflammation; Inflammatory; Injury; Intestinal permeability; Knowledge; Laboratories; Light; Link; Magnetic Resonance Imaging; Mediating; Mentored Patient-Oriented Research Career Development Award; Mentors; Modeling; National Institute on Alcohol Abuse and Alcoholism; Nerve Degeneration; Neurosciences Research; Outcome; Paper; Parents; Parietal; Participant; Peripheral; Persons; Placebos; Plasma; Procedures; Process; Production; Protocols documentation; Public Health; Publications; Publishing; Randomized; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Research Training; Risk; Risk Factors; Safety; Saliva; Sampling; Scientist; Social Distance; Solid; Structure; Sum; Testing; Time; TimeLine; Training; Training Activity; Urine; Viral Load result; Viral Proteins; Woman; alcohol effect; alcohol research; alcohol use disorder; biobehavior; career; career development; caregiving; cognitive testing; comorbidity; coronavirus disease; cytokine; design; drinking; gut bacteria; gut-brain axis; immune activation; interest; laboratory experiment; medication nonadherence; microbial; monocyte; mortality; negative affect; neuroimaging; neurotoxic; pandemic disease; payment; public health relevance; relating to nervous system; research data dissemination; response; secondary analysis; skills; symposium; translational neuroscience; white matter; white matter damage

PROJECT ABSTRACT This administrative supplement is submitted in response to NOT-OD-21-052 on “Requesting Extensions for Early Career Scientists Whose Career Trajectories Have Been Significantly Impacted by COVID-19.” Dr. Mollie Monnig’s K23 award was nearing the end of Year 4 in March 2020 when the COVID pandemic caused a nationwide shutdown. Prior to the shutdown, research and training activities were on track for timely completion. However, negative impacts of COVID have delayed the completion of research projects and training goals. The first major impact was disruption of laboratory alcohol research from March 2020-January 2021. The K23 study is an intensive lab experiment that must be conducted in person due to controlled alcohol administration and collection of biospecimens (breath, blood, saliva, and urine samples). The study cannot be adapted to remote administration in a safe or meaningful way. Resumption of data collection required creation of new safety protocols and extensive adaptation of in-person procedures (e.g., blood collection, cognitive testing, alcohol administration) to follow social distancing and biosafety guidelines. Employment contracts with research staff were honored, yet staff were not able to complete primary research duties for which they were hired. Payment of research staff during lab downtime significantly diminished the funds now available to complete data collection and to perform biomarker assays on Aim 4 outcomes. Some supplies (e.g., vacutainers) were expired and had to be disposed of. In addition to lab downtime, the PI Dr. Monnig was unable to engage fully in career development activities such as networking, grantwriting, research dissemination, and didactics due to the need to care for her two young children (under 3 years of age) at home. Dr. Monnig’s family lost access to childcare for 5 months in 2020 due to the pandemic. Thus, funds are requested to offset expenses for loss of RA effort, supplies, and PI effort. The proposed extension will allow Dr. Monnig to fully achieve K23 aims by completing data collection and analysis. Although Dr. Monnig submitted two R01 proposals while under lockdown in March and July of 2020, inability to finish K23 research on the original timeline weakened these proposals due to incomplete preliminary data. Similarly, although Dr. Monnig has published or submitted primary papers for Aims 1 and 2, research barriers and lack of childcare delayed the primary publications for Aims 3 and 4. There is clear evidence that women and junior scientists have been more severely affected by negative impacts of COVID on research, especially when they have major caregiving responsibilities.1-4 In sum, the proposed extension will support Dr. Monnig’s transition to independent investigator via completion of K23 aims, as well as key career development activities (collaborations, funding applications, publications, and networking). Dr. Monnig’s primary mentor, Dr. Peter Monti, and secondary mentor, Dr. Ronald Cohen, are very committed to the successful completion of the K23 award and will remain highly involved in Dr. Monnig’s career development, training, and research activities.

项目摘要 此行政补充是根据“要求扩展的， 早期的职业科学家，其职业轨迹受到Covid-19的重大影响。” Mollie博士 蒙尼格（Monnig）的K23奖在2020年3月的第4年末接近 全国关闭。在关闭之前，研究和培训活动正及时 完全的。但是，共同的负面影响延迟了研究项目的完成， 培训目标。第一个主要影响是从2020年1月至1月开始对实验室酒精研究的中断 2021。K23研究是一个密集的实验实验，必须亲自进行。 生物测量的给药和收集（呼吸，血液，唾液和尿液样本）。该研究不能是 以安全或有意义的方式适应远程管理。恢复数据收集需要创建 新的安全协议和广泛适应面对面程序（例如，血液收集，认知 测试，酒精管理）遵循社会距离和生物安全指南。与雇佣合同 研究人员很荣幸，但工作人员无法完成他们的主要研究职责 雇用。在实验室停机期间支付研究人员 完成数据收集并在AIM 4结果上执行生物标志物测定。一些用品（例如 真空吸收器）已过期，必须处置。除了实验室停机时间，PI Monnig博士是 无法完全从事职业发展活动，例如网络，授予写作，研究 由于需要照顾她的两个小孩（3岁以下），因此传播和教学法 家。由于大流行，蒙尼格博士的家人在2020年失去了5个月的托儿服务。那是资金 要求抵消损失RA努力，供应和PI努力的费用。拟议的扩展名将允许博士 通过完成数据收集和分析，Monnig完全实现K23的目标。虽然蒙尼格博士提交了 在2020年3月和7月的锁定期间，两项R01提案无法完成K23的研究 原始时间轴由于不完整的初步数据而削弱了这些建议。同样，尽管蒙尼格博士 已经发表或提交了针对目标1和2的主要论文，研究障碍和缺乏育儿延迟 目标3和4的主要出版物。有明确的证据表明妇女和初级科学家一直在 由于共同影响对研究的负面影响更严重，尤其是当它们具有重大影响时 1-4总的来说，拟议的扩展名将支持Monnig博士的过渡到 独立研究者通过完成K23 Aim以及关键的职业发展活动 （合作，资助应用程序，出版物和网络）。蒙尼格博士的主要导师彼得博士 蒙蒂（Monti）和二级导师罗纳德·科恩（Ronald Cohen）博士非常致力于成功完成K23 奖励，并将继续参与Monnig博士的职业发展，培训和研究活动。