University of Minnesota Clinical and TranslationalmScience Institute (UMN CTSI)

明尼苏达大学临床与转化科学研究所 (UMN CTSI)

• 批准号: 10366062
• 负责人: Bruce R Blazar
• 金额: $ 577.8万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-30 至 2023-11-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10366062
• 关键词: Administrator; Adult; Agreement; Area; Award; Biometry; Budgets; Businesses; Calendar; Childhood; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinics and Hospitals; Collection; Communication; Communities; Community Health; Community Health Services; Community Outreach; Competence; Complex; Consent; Consent Forms; Consult; County; County Hospitals; Data; Development; Development Plans; Devices; Diverse Workforce; Drops; Education; Enrollment; Ensure; Ethics; Feedback; Fostering; Funding Opportunities; Health; Health Sciences; Health Services; Health system; Hospitals; Housing; Human; Incentives; Industry; Information Management; Infrastructure; Institutes; Institutional Review Boards; Laboratory Research; Latino; Learning; Link; Location; Logic; Longevity; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Mediation; Medical; Medical center; Methods; Midwestern United States; Minnesota; Mission; Modeling; National Center for Advancing Translational Sciences; Native Americans; Operative Surgical Procedures; Participant; Partner in relationship; Pathway interactions; Patients; Pediatric Hospitals; Population; Population Heterogeneity; Price; Process; Protocols documentation; Public Health; Reduce health disparities; Research; Research Personnel; Research Support; Rewards; Science; Services; Site; System; Technology; Training; Training Programs; Translational Research; Translations; Underrepresented Populations; Underserved Population; Universities; Vision; Visit; base; biomedical informatics; care outcomes; career development; cohort; commercialization; community engagement; community involvement; community partnership; data access; data sharing; design; ethnic minority; experience; health care delivery; health outcome disparity; improved; indexing; industry partner; informatics tool; innovation; magnetic field; meetings; member; multidisciplinary; next generation; parallel processing; programs; quality assurance; racial and ethnic; recruit; responsible research conduct; safety net; skills; spectroscopic imaging; tertiary care; tool; user-friendly

Contact PD/PI: Blazar, Bruce A. Overall: Abstract. The University of Minnesota's Clinical and Translational Science Institute's (UMN CTSI) vision is a world where impactful discoveries leading to the betterment of human health occur by bringing together Academic Health Center (AHC) research with community outreach and industry partnership. Our mission is to create a nationally-recognized, shareable model of complex translational team science driven and enabled by integration and alignment of clinical and translational science (CTS) research with education, data access, community needs, and industry efforts. In the past 6 years, CTSI 1) Developed comprehensive programs for workforce training and fostering career development for the next generation of CTS research investigators; 2) Created Community Engagement to Advance Research and Community Health (CEARCH) to support stakeholder community contributions to CTS research and to tackle health outcome disparity challenges in Somali, Latino, Native American, Hmong, and other populations; 3) Leveraged UMN research strengths and MN's vibrant biomedical industry to advance multiple projects along the commercialization pathway; and 4) Expanded its patient base from the UMN tertiary care adult and pediatric hospitals to hub partners consisting of a VA hospital, a community-based 7-hospital system, and a safety-net county hospital with 65% racial/ethnic minorities linked with i2b2/SHRINE for cohort identification. CTSI formed an unprecedented partnership with Mayo CTSA to provide statewide coverage in CTS research and education and is a founding member of the Midwest Area Research Consortium for Health, the Accrual to Clinical Trials federated cohort discovery consortium, and PCORnet Greater Plains Collaborative. To accelerate and improve CTS research and education and make lasting impacts on healthcare outcomes, we will pursue the following aims: 1. Train an outstanding multidisciplinary, diverse workforce across the CTS research spectrum skilled in and rewarded for team science using existing and new educational offerings; 2. Streamline methods and processes to increase local and national CTSI hub research capacity in a new Clinics and Surgery Center learning health system with CTSI-led research process design, CTSI's new StudyFinder tool, user-friendly IRB-approved consent form for clinical and laboratory research, bioinfor- matics tools, biospecimen collection, and a transformative Clinical Research Support Center for one-stop, single location, parallel processing of needed approvals; 3. Engage communities and stakeholders through CEARCH to improve translation and healthcare delivery across the lifespan and to a diverse population; and 4. Add unique contributions to the CTSA network by the Office of Discovery and Translation , Pediatric Device Innovation Consortium, and high and ultrahigh magnetic resonance imaging and spectroscopy applications and training. Impact. Connected to and driven by its vision and mission, CTSI will provide infrastructure and services for conducting innovative, high-impact and efficient, high-quality CTS research. Project Summary/Abstract Page 391 Contact PD/PI: Blazar, Bruce

联系 PD/PI：Blazar、Bruce A. 总体：抽象。明尼苏达大学临床与转化科学研究所 (UMN CTSI）的愿景是通过以下方式实现有影响力的发现，从而改善人类健康： 将学术健康中心（AHC）的研究与社区外展和行业结合起来 合伙。我们的使命是创建一个全国认可的、可共享的复杂翻译团队模型 通过临床和转化科学 (CTS) 研究的整合和协调来驱动和实现科学 教育、数据访问、社区需求和行业努力。过去6年，CTSI 1) 发展 劳动力培训和促进下一代职业发展的综合计划 CTS 研究人员； 2) 创建社区参与以推进研究和社区 健康 (CEARCH) 支持利益相关者社区对 CTS 研究的贡献并解决健康问题 索马里人、拉丁美洲人、美洲原住民、苗族和其他人群的结果差异挑战； 3） 利用明尼苏达大学的研究优势和明尼苏达州充满活力的生物医学产业来推进多个项目 商业化途径； 4) 从 UMN 三级护理成人扩大其患者基础 儿科医院与中心合作伙伴组成的中心合作伙伴，包括 VA 医院、基于社区的 7 家医院系统和 安全网县医院，其中 65% 的少数族裔/族裔与 i2b2/SHRINE 建立联系以进行队列识别。 CTSI 与 Mayo CTSA 建立了前所未有的合作伙伴关系，提供全州范围的 CTS 覆盖 研究和教育，是中西部地区健康研究联盟的创始成员， 应计临床试验联合队列发现联盟和 PCORnet Greater Plains Collaborative。 为了加速和改进 CTS 研究和教育并对医疗保健结果产生持久影响， 我们将追求以下目标： 1. 培养一支优秀的跨学科、多元化的员工队伍 CTS 研究范围擅长利用现有和新的教育进行团队科学并获得奖励 供品； 2. 简化方法和流程，提高地方和国家 CTSI 中心的研究能力 在一个新的诊所和手术中心学习健康系统，采用 CTSI 主导的研究流程设计，CTSI 的 新的 StudyFinder 工具、用户友好的 IRB 批准的临床和实验室研究同意书、生物信息 自动化工具、生物样本采集以及变革性的一站式临床研究支持中心， 单一地点并行处理所需审批； 3. 通过以下方式让社区和利益相关者参与进来： 研究改善整个生命周期和向不同人群提供的翻译和医疗保健服务；和 4. 儿科发现和翻译办公室为 CTSA 网络添加独特贡献 设备创新联盟、高和超高磁共振成像和光谱学 应用和培训。影响。 CTSI 将与其愿景和使命相联系并受其驱动 用于开展创新、高影响力、高效、高质量的 CTS 研究的基础设施和服务。 项目摘要/摘要第 391 页 联系 PD/PI：Blazar、Bruce

项目成果

min-SIA: a Lightweight Algorithm to Predict the Risk of 6-Month Mortality at the Time of Hospital Admission.

min-SIA：一种轻量级算法，用于预测入院时 6 个月死亡率的风险。

• DOI: 10.1007/s11606-020-05733-1
• 发表时间: 2020
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Sahni,Nishant;Tourani,Roshan;Sullivan,Donald;Simon,Gyorgy
• 通讯作者: Simon,Gyorgy

Association of Weekly Protected Nonclinical Time With Resident Physician Burnout and Well-being.

每周受保护的非临床时间与住院医师倦怠和幸福感的关联。

• DOI: 10.1001/jamaoto.2019.3654
• 发表时间: 2020
• 期刊: JAMA otolaryngology-- head & neck surgery
• 作者: Stevens,Kristin;Davey,Cynthia;Lassig,AmyAnne
• 通讯作者: Lassig,AmyAnne

Neighborhood Socioeconomic Status, Health Insurance, and CKD Prevalence: Findings From a Large Health Care System.

• DOI: 10.1016/j.xkme.2021.03.008
• 发表时间: 2021-07
• 期刊: Kidney medicine
• 影响因子: 3.9
• 作者: Ghazi L;Osypuk TL;MacLehose RF;Luepker RV;Drawz PE
• 通讯作者: Drawz PE

Clinical, Virologic and Immunologic Correlates of Breast Milk Acquired Cytomegalovirus (CMV) Infections in Very Low Birth Weight (VLBW) Infants in a Newborn Intensive Care Unit (NICU) Setting.

• DOI: 10.3390/v13101897
• 发表时间: 2021-09-22
• 期刊: Viruses
• 作者: Hernandez-Alvarado N;Shanley R;Schleiss MR;Ericksen J;Wassenaar J;Webo L;Bodin K;Parsons K;Osterholm EA
• 通讯作者: Osterholm EA

Lower survival and higher rates of cirrhosis in patients with ROUX-EN-Y gastric bypass hospitalised with alcohol-associated hepatitis.

• DOI: 10.1136/bmjgast-2022-001083
• 发表时间: 2023-03
• 期刊: BMJ OPEN GASTROENTEROLOGY
• 影响因子: 3.1
• 作者: Anugwom, Chimaobi;Thomson, Mary;Freese, Rebecca L.;Lake, John R.;Lim, Nicholas
• 通讯作者: Lim, Nicholas