Genetic and Environmental Origins of the Development of Pain in Children

儿童疼痛发展的遗传和环境根源

• 批准号: 10365545
• 负责人: Mary Colleen Davis
• 金额: $ 63.31万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10365545
• 关键词: 16 year old; Address; Adolescence; Adolescent; Adult; Aerobic; Age; Arizona; Behavioral Genetics; Benign; Biological Markers; Birth Records; Buffers; Child; Child Development; Childhood; Clinical; Communities; Data; Development; Environment; Environmental Impact; Epidemiology; Epigenetic Process; Ethnic Origin; Etiology; Exposure to; Family; Frequencies; Funding; Future; Genes; Genetic; Genetic Risk; Genetic study; Glean; Growth; Health; Health Psychology; Health behavior; Heritability; High Prevalence; Immune; Intervention; Life; Link; Literature; Mediating; Methodology; Methods; Methylation; Modeling; Monozygotic twins; Muscle; Pain; Pain Disorder; Pain Measurement; Parents; Personality; Prevalence; Prevention; Process; Puberty; Questionnaires; Recovery; Research; Risk; Risk Factors; Role; Sampling; Scientist; Sex Differences; Socioeconomic Status; Stress; Symptoms; Syndrome; System; Time; Twin Multiple Birth; Youth; aging gene; base; boys; chronic pain; chronic painful condition; clinical pain; clinically significant; critical developmental period; design; diaries; early childhood; early life adversity; emotion dysregulation; emotion regulation; ethnic diversity; follow up assessment; genetic association; girls; hypothalamic-pituitary-adrenal axis; infancy; interest; methylation pattern; middle childhood; novel; optimism; parent project; prevent; public health relevance; resilience; sleep quality; social; social relationships; stress management; transmission process

Project Summary Pediatric chronic pain is a common but understudied health problem, with prevalence increasing from childhood to adolescence, particularly among girls. Moreover, prevalence rates have increased over the past 20 years for unknown reasons. Despite the high prevalence and enduring impact, we know little about its etiology and developmental progression. The literature documents associations between exposure to early adversity and chronic pain among adults, but little is known about the early developmental time course, key mechanisms, and social resilience that can mitigate risk in youth. Critical questions need to be addressed before efforts at prevention and intervention can have maximum impact. To that end, the proposed competing continuation project focuses on four aims: identify the genetic and environmental influences on growth in pain across childhood and adolescence (Aim1); examine the role of stress exposure in the development of children's chronic pain (Aim 2); and evaluate two potential mechanisms linking stress and pain, problems with emotion regulation (Aim 3), and epigenetics (Aim 4). Under a recalibration model, we also explore social resilience in adolescence as a buffer of these risk processes. To accomplish our aims, we propose to conduct intensive longitudinal follow-up assessments (at 14, 15, and 16 years of age) of a birth-records-based community sample of 350 pairs of twins who are diverse in ethnicity and socioeconomic status. Stress, emotion regulation, and recurring pain during early and middle childhood have already been well characterized. Assessments during adolescence will take a multi-method approach that includes clinical and diary assessments of pain frequency, intensity, duration; objective, diary, and questionnaire assessments of emotion regulation, stress, and social resilience; and objective assessments of epigenetics. Our genetically informed developmental approach to understanding the etiology and mechanisms of pain in youth is critical to determining when benign chronic pain is clinically significant and identifying key targets for intervention efforts to prevent the development of and promote recovery from chronic pain among youth.

项目概要 小儿慢性疼痛是一种常见但尚未得到充分研究的健康问题，患病率从 童年到青春期，尤其是女孩。此外，患病率较过去有所上升 20年了，原因不明。尽管流行率很高且影响持久，但我们对其知之甚少 病因学和发育进展。文献记录了早期接触环境之间的关联 成年人的逆境和慢性疼痛，但人们对早期发育时间过程知之甚少，关键 可以减轻青年风险的机制和社会复原力。需要解决的关键问题 预防和干预工作才能发挥最大作用。为此，拟议的竞争 延续项目侧重于四个目标： 确定遗传和环境对疼痛生长的影响 跨越童年和青春期（目标1）；检查压力暴露在发展中的作用 儿童慢性疼痛（目标 2）；并评估连接压力和疼痛的两种潜在机制、问题 情绪调节（目标 3）和表观遗传学（目标 4）。在重新校准模型下，我们还探索社交 青春期的复原力作为这些风险过程的缓冲。为了实现我们的目标，我们建议进行 基于出生记录的密集纵向随访评估（14、15 和 16 岁） 350 对双胞胎的社区样本，这些双胞胎具有不同的种族和社会经济地位。压力， 情绪调节和儿童早期和中期反复出现的疼痛已经得到很好的改善 特点。青春期的评估将采取多种方法，包括临床和 疼痛频率、强度、持续时间的日记评估；客观、日记和问卷评估 情绪调节、压力和社会适应力；和表观遗传学的客观评估。我们的基因 了解青少年疼痛的病因和机制的知情发展方法对于 确定良性慢性疼痛何时具有临床意义并确定干预工作的关键目标 预防青少年慢性疼痛的发展并促进其康复。