Research Network on Animal Models to Understand Social Dimensions of Aging

了解衰老社会维度的动物模型研究网络

• 批准号: 10365946
• 负责人: Alessandro Bartolomucci
• 金额: $ 32.69万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10365946
• 关键词: Address; Advanced Development; Age; Aging; Alcoholism; American; Animal Experimentation; Animal Model; Animals; Applications Grants; Area; Awareness; Behavior Therapy; Behavioral; Biological; Biological Assay; Biological Markers; Cardiovascular Diseases; Catalysis; Clinical Research; Collaborations; Collection; Communities; Complex; Controlled Environment; Data; Data Set; Dementia; Dimensions; Discipline; Disease; Educational workshop; Environment; Etiology; Exhibits; Fellowship; Generations; Goals; Grant; Health; Human; Interdisciplinary Communication; Knowledge; Leadership; Link; Longevity; Malignant Neoplasms; Mammals; Marmota; Mentors; Mentorship; Methodology; Methods; Modeling; Monoclonal Antibody R24; Morbidity - disease rate; Nature; Obesity; Outcome Measure; Paper; Pathway interactions; Pattern; Personal Satisfaction; Physiological; Pilot Projects; Population; Population Study; Predisposition; Protocols documentation; Publications; Research; Research Design; Research Personnel; Rodent; Scientist; Silk; Social Behavior; Social Environment; Social Impacts; Social Interaction; Social isolation; Social support; Socioeconomic Status; Standardization; Stress; Technology; Testing; Therapeutic Intervention; Time; Training; Training Support; Translations; Travel; United States; Work; Yang; aging population; animal data; animal model development; behavioral study; career; comparative; cost; data sharing; design; experience; experimental study; flexibility; genomic data; human data; human model; human population study; improved; innovation; interest; low socioeconomic status; meetings; mortality; nonhuman primate; programs; recruit; sedentary; social; social adversity; social determinants; social factors; social health determinants; social relationships; social stress; symposium; therapeutic evaluation; tool; translational applications; working group

Project Summary As the population of the United States ages, the health burden imposed by diseases of aging is expected to increase concomitantly. Social factors, including low socioeconomic status, social isolation, and low social support, are among the best predictors of susceptibility to diseases of aging, as well as lifespan itself. Nevertheless, key questions about the causal relationship and the biological mechanisms that link social experiences to health and aging remain unanswered. Animal models are a powerful tool to address these questions. Like humans, other social mammals exhibit strong associations between social adversity, health, and mortality. Unlike humans, though, they experience less complex environments, have shorter generation times, and can be subjected to experimental manipulation in controlled environments. The goal of this proposal is to build a Research Network on Animal Models to Understand Social Dimensions of Aging. By supporting interdisciplinary communication and pilot research from both human and nonhuman animal researchers, we aim to maximize the impact of animal model research on understanding the social determinants of health and aging. A Research Network is essential because current research in this area is distributed across many different disciplines, there is no standard set of conferences or publication venues where researchers with related interests overlap, and there are high barriers to entry for animal model work. The proposed network will overcome these challenges by supporting scientific meetings and workshops that build contacts across disciplines and among researchers at all career levels. It will also recruit new, diverse investigators into the field by providing opportunities for pilot project support, travel fellowships, and mentorship by experienced senior investigators. As part of these activities, the network will provide hands-on training for animal model research in rodents and nonhuman primates and for comparative research that leverages human and animal data sets. To build visibility, it will support targeted symposia at meetings where animal model work on the social dimensions of aging has not traditionally been represented. Finally, it will identify priority areas for animal model research and promote data and protocol dissemination. These activities will help set a research agenda that extends beyond the network’s immediate activities. Thus, the proposed network will transform a weakly connected community into a self-sustaining field of researchers equipped to conduct impactful research on the social dimensions of aging. Areas of particular interest include models to test the causal effects of social interactions on health; methods that can be flexibly deployed in both nonhuman animals and human populations; and research that investigates the benefits of behavioral interventions for alleviating the costs of social adversity. Advances in these areas will have direct translational application to human health and well-being during aging.

项目摘要 随着美国年龄的人口，预计将由衰老疾病施加的健康伯恩 社会因素，包括社会经济状况低下，社会隔离和社会较低的社会因素 支持是对衰老疾病易感性以及寿命本身的最佳预测指标。 然而，有关因果关系的关键问题和联系社会的生物学机制 健康和衰老的经验仍未得到答复。动物模型是解决这些问题的强大工具 问题。像人类一样，其他社会哺乳动物在社交广告，健康， 和死亡率。不过，与人类不同，他们经历了较不复杂的环境，其一代较短 时间，可以在受控环境中进行实验操作。 该提案的目的是建立有关动物模型的研究网络以了解社会 衰老的尺寸。通过支持人类和人类的跨学科沟通和试点研究 非人类动物研究人员，我们旨在最大化动物模型研究对理解的影响 健康和衰老的社会决定者。研究网络至关重要，因为目前的研究 区域分布在许多不同的学科中，没有标准的会议或出版物 具有相关兴趣重叠的研究人员的风险投资者，动物模型的进入障碍很高 工作。拟议的网络将通过支持科学会议和研讨会来克服这些挑战 这在各个职业级别之间以及研究人员之间建立了联系。它也将招募新的 通过为试点项目支持，旅行奖学金和 经验丰富的高级调查员的资产。作为这些活动的一部分，网络将提供动手 在啮齿动物和非人类私人方面的动物模型研究培训以及对比较研究的培训 利用人类和动物数据集。为了建立可见性，它将在会议上支持有针对性的专题讨论会 传统上，动物模型在衰老的社会层面上的工作并未得到代表。最后，会 确定动物模型研究的优先领域，并促进数据和协议传播。这些活动 将有助于建立一项研究的Agernda，该研究超出了网络的即时活动。 这是，提议的网络将把一个弱连接的社区转变为一个自我维持的领域 研究人员能够对衰老的社会层面进行有影响力的研究。特别的区域 兴趣包括测试社会互动对健康的因果影响的模型；可以灵活的方法 部署在非人类动物和人类种群中；和研究的研究 减轻社交广告费用的行为干预措施。这些领域的进步将直接 在衰老期间，对人类健康和福祉的翻译应用。