Behavioral Phenoptying Core

行为表型分析核心

• 批准号: 10765813
• 负责人: David A Williams
• 金额: $ 27.46万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-26 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10765813
• 关键词: Behavioral; Phenoptying; Core

PROJECT SUMMARY / ABSTRACT BEHAVIORAL PHENOTYPING CORE (BPC) The NIH BACPAC initiative is designed to “generate new knowledge regarding phenotypes, endotypes, mechanisms, diagnostics, trial outcomes, and therapeutic responsiveness . . . in chronic low back pain (cLBP). This proposal, to lead a Mechanistic Research Center (MRC) as part of the broader BACPAC initiative, includes a Research Core that takes advantage of a multidisciplinary team at University of Michigan which has been characterizing and studying a wide variety of chronic pain conditions for over 20 years. Members of this Core have either led or participated in the design and conduct of large clinical and network based projects that have required clinical and behavioral phenotyping such as the Department of Defense (DoD) studies of Gulf- War Illnesses, the NIH/NIDDK MAPP initiative, the NIAMS CORT, and registration trials for industry. The co- Directors and members of this Core have also been involved in the development and validation of PROMIS derived measures for chronic overlapping conditions which includes cLBP. For this application, the Behavioral Phenotyping Core (BPC) faculty have designed a comprehensive phenotyping battery that incorporates multi- domain self-report questionnaires (derived largely from PROMIS, the NINDS common data elements, or recommendations from the NIH Chronic Low Back Pain Task Force) along with multi-modal assessment strategies such as ambulatory monitoring (e.g., actigraphy and ecological momentary assessment (EMA)) and functional capacity examination (Specific Aim 2). Our phenotyping occurs at baseline and longitudinally throughout the project and corresponds with the effort of the Neurobiological Phenotyping Core (NPC) (Specific Aim 3). The BPC team has also contributed to the design of the research project and selection of relevant primary and secondary outcomes for the study including a priori mechanistic hypothesis-based outcomes specific to the purported actions of each intervention. In order to support the integrity of the research project, this Core also designed indices of treatment fidelity, adherence, credibility, and expectancy (e.g., Specific Aim 1). Finally, the BPC is eager to contribute to the broader BACPAC initiative by having our well- characterized cohort of cLBP patients serve as a resource for the larger NIH BACPAC initiative and by contributing scientific expertise, research methods, and leadership to BACPAC.

项目概要/摘要 行为表型核心 (BPC) NIH BACPAC 计划旨在“生成有关表型、内型、 慢性腰痛 (cLBP) 的机制、诊断、试验结果和治疗反应。 该提案旨在领导一个机械研究中心 (MRC)，作为更广泛的 BACPAC 计划的一部分， 包括一个研究核心，利用密歇根大学的多学科团队，该团队 20 多年来，该组织的成员一直在描述和研究各种慢性疼痛状况。 Core 领导或参与了大型临床和网络项目的设计和实施，这些项目 需要进行临床和行为表型分析，例如国防部 (DoD) 对海湾地区的研究 战争疾病、NIH/NIDDK MAPP 计划、NIAMS CORT 以及行业注册试验。 该核心的董事和成员也参与了 PROMIS 的开发和验证 针对慢性重叠病症的衍生测量，其中包括 cLBP。 表型核心 (BPC) 教师设计了一种综合表型分析电池，其中包含多种 领域自我报告调查问卷（主要源自 PROMIS、NINDS 通用数据元素，或 NIH 慢性腰痛工作组的建议）以及多模式评估 诸如动​​态监测（例如体动记录和生态瞬时评估（EMA））等策略 功能能力检查（具体目标 2）我们的表型分析是在基线和纵向进行的。 贯穿整个项目，并与神经生物学表型核心 (NPC) 的努力相对应 （具体目标 3） BPC 团队还为研究项目的设计和选择做出了贡献。 研究的相关主要和次要结果，包括基于先验机制假设的 针对每项干预措施的特定行动的结果，以支持研究的完整性。 项目中，该核心还设计了治疗保真度、依从性、可信度和预期的指标（例如， 具体目标 1) 最后，BPC 渴望通过我们的良好 - 为更广泛的 BACPAC 倡议做出贡献。 具有特征的 cLBP 患者队列可作为更大的 NIH BACPAC 计划的资源，并且通过 为 BACPAC 贡献科学专业知识、研究方法和领导力。