HEALing LB3P: Profiling Biomechanical, Biological and Behavioral phenotypes

HEALing LB3P：分析生物力学、生物和行为表型

• 批准号: 10765804
• 负责人: NAM V VO
• 金额: $ 39.62万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-26 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10765804
• 关键词: HEALing; LB3P; Profiling; Biomechanical; Biological

ABSTRACT The purpose of the University of Pittsburgh Low Back Pain: Biological, Biomechanical, Behavioral Phenotypes (LB3P) Mechanistic Research Center is to perform in-depth phenotyping of patients with chronic low back pain (CLBP), using a multi-modal approach, to characterize patients and provide insight into the phenotypes associated with experience of CLBP to direct targeted and improved treatments. This new center will uniquely address the critical challenge facing care for patients with CLBP, which is the rising costs of care related to failed treatments, and resultant loss of quality of life and function with increasing reliance on opioid use resulting from our inability to properly select patients for properly targeted treatments with a high likelihood of success. The LB3P MRC will be formed of three Research Cores, which will be primarily responsible for data collection and analysis of the three key contributors to CLBP (Biological, Biomechanical, and Behavioral); three support cores primarily responsible for data organization, processing, storage and dissemination, including interactions with the BACPAC (Administrative, Clinical, and Informatics); and one Research Project (deep phenotyping of CLBP patient characteristics and response to treatments), serving to leverage all of the services and products of the individual cores into the development of a unique clinical set of phenotypes associated with response to treatment to guide properly targeted, individualized future care models for CLBP. This approach will leverage and integrate distinctive resources at the University of Pittsburgh laboratories to deliver quantified biomechanical, biological, and behavioral characteristics, functional assessments and patient-reported outcomes, coupled with advanced data analytics using a novel Network Phenotyping Strategy (NPS). A comprehensive and integrated biopsychosocial approach will be employed, which is necessary to improve treatment for this complex and multi-dimensional condition. It is critical that the interaction of individual variables is maintained in any phenotyping strategy, since in the syndrome of CLBP there is significant interaction of each contributor, and this is an important strength of the proposed approach. The formation of this center will build upon existing strengths within the University of Pittsburgh research community and focus efforts around the critical challenge of CLBP, and the collaborative approach will serve as an important resource for the BACPAC community. The LB3P MRC will coordinate the interdisciplinary expertise of clinicians and researchers to study the contributors and predictors of CLBP, and to propose a culminating research project that promises to translate the findings to clinical utilization and change the paradigm of care for CLBP. The proposed approach, by eliminating isolated and disconnected approaches to treatment, and instead focusing on personalized patient- centric approaches, will yield improved outcomes and patient satisfaction. In addition, the robust environment, including an academic medical center with an integrated care delivery and finance system, will ensure rapid and efficient translation of the results into novel care models for CLBP patients.

抽象的 匹兹堡大学下背痛的目的：生物学，生物力学，行为表型 （LB3P）机械研究中心是对患有慢性下腰痛患者的深入表型 （CLBP），使用多模式方法来表征患者并提供对表型的见解 与CLBP的经验有关，以指导有针对性和改进的治疗方法。这个新中心将唯一 应对CLBP患者的护理面临的关键挑战，这是与 治疗失败，以及由于增加对阿片类药物使用的依赖而导致的生活质量和功能丧失，从而 从我们无法正确选择患者进行适当靶向治疗的可能性很高 成功。 LB3P MRC将由三个研究核心组成，这将主要负责数据 收集和分析CLBP的三个关键因素（生物学，生物力学和行为）； 三个支持核心主要负责数据组织，处理，存储和传播，包括 与BACPAC（行政，临床和信息学）的相互作用；和一个研究项目（深 CLBP患者特征和对治疗的反应的表型），以利用所有服务 与各个核心的产物一起开发了与之相关的独特临床表型 对治疗的反应，以指导CLBP的正确靶向，个性化的未来护理模型。这种方法 将利用和整合匹兹堡大学实验室的独特资源来提供量化的 生物力学，生物学和行为特征，功能评估和患者报告 结果，再加上新型网络表型策略（NP）的高级数据分析。一个 将采用全面和综合的生物心理社会方法，这对于改进是必要的 治疗这种复杂和多维条件。至关重要的是个人的互动 任何表型策略中都保持变量，因为在CLBP综合征中 每个贡献者的相互作用，这是拟议方法的重要优势。这个形成 中心将基于匹兹堡大学研究界的现有优势，并集中精力 围绕CLBP的关键挑战，以及协作方法将成为 BACPAC社区。 LB3P MRC将协调临床医生和研究人员的跨学科专业知识 研究CLBP的贡献者和预测因素，并提出一个最终的研究项目，该项目有望 将发现转化为临床利用，并更改CLBP护理的范式。提出的方法， 通过消除孤立的和断开的治疗方法，而专注于个性化的患者 - 以中心的方法将带来改善的结果和患者满意度。此外，强大的环境， 包括具有综合护理交付和融资系统的学术医疗中心，将确保快速 有效地将结果转换为CLBP患者的新型护理模型。