A Synchrotron Radiation Structural Biology Resource

同步辐射结构生物学资源

基本信息

批准号：
10350698
负责人：
BRITT HEDMAN
金额：
$ 56.34万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10350698
关键词：
Biological Biomedical Research Clinic Collaborations Communities Complex Computer software Cryoelectron Microscopy Crystallization Crystallography Data Data Analyses Detection Education and Outreach Educational workshop Electronics Experimental Designs Fostering Generations Goals Hybrids Image In Situ Individual International Investments Length Libraries Ligand Binding Measurement Medical Imaging Methods Modification Molecular Biology Optics Peer Review Performance Phase Process Research Resolution Resources Roentgen Rays Sampling Schedule Schools Science Scientist Services Site Source Spectrum Analysis Synchrotrons System Techniques Technology Temperature Time Training Training Programs Training Support United States X ray spectroscopy absorption base biological systems design detector experience experimental study future implementation imaging facilities imaging program improved innovation innovative technologies instrumentation millisecond multimodality online resource operation outreach outreach program spectroscopic imaging structural biology submicron success synchrotron radiation theories tool web portal

项目摘要

Synchrotron radiation (SR) is an extremely bright and tunable x-ray source that enables forefront research in structural molecular biology (SMB). The goal of “A Synchrotron Structural Biology Resource" at the Stanford Synchrotron Radiation Lightsource (SSRL) is to provide users access to an integrated, mature SMB Resource with state-of-the-are synchrotron beam line facilities for macromolecular crystallography, x-ray absorption/emission/imaging spectroscopy and small angle x-ray scattering/diffraction, that form the three Resource Technical Operations Cores. Special emphasis is to create streamlined user access, provide dedicated user support and services, to train users, and to perform outreach on the scientific benefits of the capabilities of these specialized, yet mature facilities to the biomedical research community. Multiple innovative access mechanisms will be provided, that will include both single- and multiple-technique approaches to access the Cores, based on a transparent and robust external peer-review process. A multifaceted training and outreach program will include individual training, workshops, summer schools, on-the-road, and support clinic segments by experienced science and technical staff. A Resource web portal will provide streamlined scientific, technical, training, outreach and administrative material and other relevant information. A principal aim is to optimize and maintain, for reliable and forefront performance, experimental facilities and instrumentation, detectors, software and computing and network capabilities on the SMB Resource’s 8+ beam lines at SSRL, capitalizing on the high SR x-ray performance of SSRL’s 3rd generation storage ring SPEAR3, and at the MFX station at LCLS. A multi-facility proposal mechanism will facilitate access to complementary Cryo-EM and LCLS stations on-site at SLAC. With a specialized focus on user training, support and service, the SMB Resource will enable the scientific success for challenging and routine projects in the biomedical sciences.

同步加速器辐射（SR）是一种极其明亮且可调的X射线源，可实现最前沿结构分子生物学（SMB）的研究。 “同步结构生物学的目标资源“在斯坦福同步辐射光线（SSRL）的资源”是为用户访问提供具有最新的同步光束线设备的集成，成熟的SMB资源大分子晶体学，X射线抽象/发射/成像光谱和小角度X射线散射/衍射，形成了三个资源技术操作核心。特别重点是创建精简的用户访问，提供专用的用户支持和服务，培训用户，并对能力的科学利益进行宣传这些专门的但成熟的设施是生物医学研究界的。多重创新将提供访问机制，其中包括单一和多技术基于透明且强大的外部同行评审访问核心的方法过程。多方面的培训和外展计划将包括个人培训，研讨会，经验丰富的科学和技术的暑期学校，公路和支持诊所职员。资源Web门户将提供精简的科学，技术，培训，外展和行政材料和其他相关信息。主要目的是优化和维护，为了获得可靠和最前沿的性能，实验设施和仪器，探测器， SMB资源在SSRL的8+梁线上的软件，计算和网络功能，利用SSRL的第三代存储环Spear3的高SR X射线性能，在LCLS的MFX站。多物种提案机制将有助于访问 SLAC的现场完全冷冻EM和LCLS站。专门关注用户培训，支持和服务，SMB资源将为挑战带来科学成功和生物医学科学中的常规项目。