CPRC Resources

CPRC 资源

基本信息

批准号：
10348649
负责人：
Melween I. Martinez
金额：
$ 215.51万
依托单位：
UNIVERSITY OF PUERTO RICO MED SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1987
资助国家：
美国
起止时间：
1987-04-15 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10348649
关键词：
Acquired Immunodeficiency Syndrome Affect Aging Anatomy Animals Applied Research Area Atherosclerosis Behavior Behavioral Behavioral Sciences Biological Warfare Biology Biomedical Research Caribbean region Caring Cercopithecine Herpesvirus 1 Collaborations Collection Communities Comparative Study DNA Sequence Databases Dengue Development Developmental Biology Disease Drug Targeting Ensure Exhibits Funding Gene Mutation Genes Genetic Genome Goals Grant Head Health Human India Infrastructure International Island Laboratories Life Cycle Stages Macaca Macaca mulatta Malaria Malignant Neoplasms Medical Modeling Monitor Monkeys Morphology Nerve Degeneration Neurobiology Neurosciences Neurosciences Research Oral health Orthologous Gene Pathologic Pathology Personal Satisfaction Physiological Population Pre-Clinical Model Primates Reproductive Biology Research Research Personnel Research Project Grants Research Support Resources Rhesus SIV Science Simian T-lymphotropic virus 1 Skeleton Translational Research Type D Retrovirus United States National Institutes of Health Virus Well in self base behavioral study biodefense computerized design drug development endometriosis human disease improved intergenerational member multidisciplinary nonhuman primate operation programs reference genome reproductive skeletal stressor vaccine development virology

项目摘要

PROJECT SUMMARY/ABSTRACT: The major goal of this application is to improve and maintain the Caribbean Primate Research Center's (CPRC) unique research resources through support of operations, administration, veterinary care and research. The CPRC consists of four integrated facilities: (1) Cayo Santiago Field Station, the most valuable of the CPRC research resources that holds a colony of free-ranging rhesus brought from India to Cayo Santiago (CS) in 1938.; (2) the Sabana Seca Field Station, the CPRC's head quarters located 10 miles outside of San Juan that houses rhesus monkeys derived from Cayo Santiago colony in various outdoor configurations for biomedical and behavioral studies that are not feasible on free-ranging animals; (3) the Laboratory of Virology and Genetics (LVG), located on the Medical Sciences Campus (MSC), in San Juan which support several research initiatives using rhesus monkeys as a model; and (4) the Laboratory of Primate Morphology (LPM), which is also located on the MSC, and houses the CPRC skeletal collections, unique assemblages of nonhuman primate skeletons for genetic, developmental, pathological and anatomical research. As described in this proposal, CPRC is organized into four complementary and integrated divisions: Primate Resources, Virology and Genetics, Behavior and Neurosciences, and Primate Morphology. Funds are requested in this application to maintain CPRC basic infrastructure of Primate Resources, which are used to support numerous research projects locally, national and internationally. This grant will also allow CPRC to continue supporting the Translational Science Initiative (TSI) under the Applied Research Component. A major strength of this TSI is conducting multidisciplinary collaborative studies to establish and validate NHP models for preclinical translational projects related to different human diseases. With continued NIH support, the CPRC will remain a significant national research resource and will be able to provide healthy Indian-origin rhesus monkeys of defined genetic and virological background to NIH-sponsored research programs.

项目摘要/摘要：此应用程序的主要目标是改进和维护加勒比灵长类动物研究中心 (CPRC) 通过对运营、管理、兽医护理和研究的支持，获得独特的研究资源。这 CPRC由四个综合设施组成：（1）圣地亚哥岛现场站，CPRC最有价值的设施研究资源，拥有一群 1938 年从印度带到圣地亚哥岛 (CS) 的自由放养恒河猴。 (2) Sabana Seca 现场站，CPRC 总部，位于圣胡安郊外 10 英里，设有来自圣地亚哥岛殖民地的恒河猴在各种户外配置中用于生物医学和对自由放养的动物进行不可行的行为研究；（三）病毒学与遗传学实验室（LVG），位于圣胡安医学科学园区（MSC），支持多项研究计划以恒河猴为模型； (4) 灵长类动物形态学实验室 (LPM)，也位于位于 MSC 上，拥有 CPRC 骨骼收藏，这是非人类灵长类骨骼的独特组合遗传、发育、病理和解剖学研究。如本提案所述，CPRC 的组织分为四个互补和综合的部门：灵长类资源、病毒学和遗传学、行为和神经科学和灵长类动物形态学。本申请要求资金以维持 CPRC 的基本灵长类动物资源基础设施，用于支持当地、国家和地区的众多研究项目国际上。这笔赠款还将允许 CPRC 继续支持转化科学计划 (TSI) 在应用研究部分下。该 TSI 的主要优势是开展多学科研究合作研究，建立和验证 NHP 模型，用于与以下相关的临床前转化项目不同的人类疾病。在 NIH 的持续支持下，CPRC 将继续成为重要的国家研究机构资源，并将能够提供具有明确遗传和病毒学特征的健康的印度原产恒河猴 NIH 资助的研究项目的背景。