Hormones & Behavior Core

荷尔蒙

• 批准号: 10334231
• 负责人: Laura Schrader
• 金额: $ 30.91万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10334231
• 关键词: Age; Aging; Alzheimer' s disease related dementia; Animal Model; Animals; Area; Behavior; Behavior assessment; Behavioral; Biological; Brain; Cardiovascular Diseases; Clinic; Cognition; Cognitive; Cognitive aging; Collaborations; Communities; Data; Data Analyses; Data Collection; Dietary Component; Disease; Disease model; Engineering; Ensure; Equipment; Estradiol; Estrogen Therapy; Estrogens; Evaluation; Experimental Designs; Female; Goals; Gold; Grant; Health; Hippocampus (Brain); Hormones; Human Resources; Individual; Institution; Investigation; Lead; Measurement; Measures; Memory; Menopause; Methods; Modeling; Obesity; Operative Surgical Procedures; Ovariectomy; Parents; Pathologic; Performance; Prefrontal Cortex; Procedures; Protocols documentation; Radial; Reproducibility; Reproductive History; Research; Research Design; Research Personnel; Research Project Grants; Rodent; Rodent Model; Schools; Science; Services; Standardization; Testing; TimeLine; Work; arm; behavior test; cardiometabolism; cognitive function; hormone therapy; in vivo; medical schools; middle age; novel; pathological aging; programs; sensory discrimination; spatial memory; subcutaneous; success; web site

Hormones & Behavior Core (Core C) Summary The goals of the parent Program Project are to investigate possible mechanistic determinants of reduced estradiol efficacy on female cognitive aging under pathological conditions, such as cardiovascular disease and obesity. In order to assess mechanisms by which estradiol’s switch from beneficial for cognitive function to neutral or even detrimental may occur, the projects in this proposal will investigate cognitive function in aging female rodents under varying conditions of cardiometabolic health and disease both with and without estradiol treatment. Core C (Hormones & Behavior Core) will facilitate this work and contribute to the success of the overall Program Project through the completion of two specific aims. Aim 1 will establish a rodent model of menopause and hormone therapy that is uniform across all four projects, and Aim 2 will enhance rigor and reproducibility by standardizing the behavioral tests and assessments used across studies. Core services within a program project are advantageous compared to independent investigations as they allow for careful planning and coordination of research design, disease models, and data collection and analysis among all projects which would otherwise prove difficult for researchers with separate grants at separate institutions. This coordination will significantly impact the scope of the research by eliminating project-specific variability in biological age, timelines, dietary components, and disease models and thus permitting inferences between studies that could otherwise never be made.

激素与行为核心（核心C）摘要 父母计划项目的目标是调查可能减少的机械决定者 在病理状况下，例如心血管疾病和 肥胖。为了评估雌二醇从认知功能有益的机制 可能发生中性甚至有害，该提案中的项目将研究衰老的认知功能 在有或没有雌二醇的情况下，雌性啮齿动物在心脏代谢健康和疾病的不同条件下 治疗。核心C（激素和行为核心）将有助于这项工作，并为成功的成功做出贡献 通过完成两个具体目标，总体计划项目。 AIM 1将建立一个啮齿动物模型 在所有四个项目中都均匀的更年期和马内治疗，AIM 2将增强严格和 通过标准化研究中使用的行为测试和评估来重现性。内部的核心服务 与独立调查相比，计划项目是有利的，因为它们允许仔细计划 以及研究设计，疾病模型以及数据收集和分析的所有项目的协调 否则，对于单独的机构的单独赠款的研究人员来说，很难被证明。这个协调 通过消除生物年龄特定项目的变异性，将显着影响研究范围， 时间表，饮食成分和疾病模型，因此可以推断研究之间的推论 否则永远不会做。