Cardiometabolic Core

心脏代谢核心

• 批准号: 10334230
• 负责人: Sarah H. Lindsey
• 金额: $ 48.22万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10334230
• 关键词: Animal Feed; Animals; Area; Biological Markers; Blood Pressure; Body Composition; Body Weight; Calendar; Cardiac; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cognitive aging; Communities; Data; Data Collection; Diet; Disease; Disease model; Engineering; Ensure; Enzyme-Linked Immunosorbent Assay; Equipment; Estrogens; Experimental Designs; Extramural Activities; Female; Glucagon; Glucose tolerance test; Goals; Health; High Fat Diet; Housing; Human Resources; Insulin; Maintenance; Measurement; Metabolic; Metabolic Diseases; Metabolic hormone; Monitor; Mus; Phytoestrogens; Procedures; Protocols documentation; Radioimmunoassay; Rattus; Renin-Angiotensin System; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Reservations; Resources; Sampling; Schedule; Schools; Science; Services; Standardization; System; Tissue Banks; Tissues; cardiometabolism; experience; feeding; forest; improved; in vivo; insulin tolerance; medical schools; meetings; programs; sample collection; standardize measure; synergism; ultrasound; web site

Cardiometabolic Core (Core B) Summary The Cardiometabolic Core (Core B) will allow for the careful planning and coordination of research designs, disease models, and data collection among the four Research Projects. The Core will be utilized for the induction, maintenance, and analysis of cardiometabolic diseases in rats and mice. Core B will be a newly established facility housing the equipment and personnel for standardized measures in the proposed Research Projects. The specific functions of Core B are organized into three Aims. Aim 1 will employ standardized animal diets and specimen collection across all four projects. It will ensure that feeding, monitoring, and tissue collection are consistent across projects and will establish a tissue bank available to Tulane and extramural researchers. Aim 2 will employ standardized metabolic measurements across all four projects to provide the same metabolic conditions and measurements. Aim 3 will employ standardized cardiovascular measurements across all four projects to ensure that cardiovascular disease is implemented equally in rats and mice. This coordination among the projects will improve the scope of the research by allowing inferences between studies that could not be made if each project introduced new variables. In addition, Core B will maintain standardized protocols and procedures to allow comparison of data across studies and thereby will improve rigor and reproducibility.

心脏代谢核心（核心B）摘要 心脏代谢核心（核心B）将允许对研究设计的仔细计划和协调 疾病模型和四个研究项目中的数据收集。核心将用于感应， 维持和分析大鼠和小鼠的心脏代谢疾病。核心将是新成立的 设施在拟议的研究项目中为设备和人员提供标准化措施。 核B的特定功能分为三个目标。 AIM 1将采用标准的动物饮食和 所有四个项目的标本收集。它将确保喂养，监测和组织收集 整个项目都一致，并将建立可用于图兰和校外研究人员的组织库。目的 2将在所有四个项目中采用标准化的代谢测量来提供相同的代谢 条件和测量。 AIM 3将在所有四个中采用标准化的心血管测量 项目以确保在大鼠和小鼠中同样实施心血管疾病。这种协调 这些项目将通过允许在研究之间推断不可能的推论来改善研究的范围 如果每个项目都引入了新变量，则进行。此外，核心B将维护标准化协议，并且 可以比较跨研究的数据，从而可以提高严格性和可重复性。