Deployment of a Mobile Broadband BCI

移动宽带 BCI 的部署

• 批准号: 10339314
• 负责人: John David Simeral
• 金额: --
• 依托单位: PROVIDENCE VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10339314
• 关键词: Adopted; Algorithmic Software; Algorithms; Amyotrophic Lateral Sclerosis; Artificial Arm; Assessment tool; Beds; Brain; Calibration; Caregivers; Characteristics; Charge; Clinical Trials; Code; Communication; Computer software; Computers; Custom; Data; Data Collection; Detection; Devices; Electronic Mail; Evaluation; Event; Funding; Future; Goals; Hand; Home; Implant; Implanted Electrodes; Individual; Institutional Review Boards; Internet; Intervention; Intuition; Investigation; Language; Laws; Life; Limb structure; Locked-In Syndrome; Logic; Manuals; Measures; Medical Device; Methods; Monitor; Movement; Muscle; Neurologic; Paralysed; Participant; Patients; Pattern; Performance; Periodicity; Procedures; Process; Publishing; Quadriplegia; Questionnaires; Research; Schedule; Self-Help Devices; Signal Transduction; Site; Speed; Spinal cord injury; Stream; Stroke; Supervision; Surveys; System; Systems Integration; Tablets; Technology; Testing; Time; Training; Translating; United States; United States National Aeronautics and Space Administration; User-Computer Interface; Veterans; Wheelchairs; Wireless Technology; Work; arm; assistive robot; base; brain computer interface; computing resources; design; digital; engineering design; expectation; experience; grasp; handheld mobile device; improved; indexing; innovation; instrument; kinematics; mobile application; mobile computing; neuroregulation; neurotransmission; next generation; novel; operation; programs; prototype; relating to nervous system; satisfaction; signal processing; usability; Adopted; Algorithmic Software; Algorithms; Amyotrophic Lateral Sclerosis; Artificial Arm; Assessment tool; Beds; Brain; Calibration; Caregivers; Characteristics; Charge; Clinical Trials; Code; Communication; Computer software; Computers; Custom; Data; Data Collection; Detection; Devices; Electronic Mail; Evaluation; Event; Funding; Future; Goals; Hand; Home; Implant; Implanted Electrodes; Individual; Institutional Review Boards; Internet; Intervention; Intuition; Investigation; Language; Laws; Life; Limb structure; Locked-In Syndrome; Logic; Manuals; Measures; Medical Device; Methods; Monitor; Movement; Muscle; Neurologic; Paralysed; Participant; Patients; Pattern; Performance; Periodicity; Procedures; Process; Publishing; Quadriplegia; Questionnaires; Research; Schedule; Self-Help Devices; Signal Transduction; Site; Speed; Spinal cord injury; Stream; Stroke; Supervision; Surveys; System; Systems Integration; Tablets; Technology; Testing; Time; Training; Translating; United States; United States National Aeronautics and Space Administration; User-Computer Interface; Veterans; Wheelchairs; Wireless Technology; Work; arm; assistive robot; base; brain computer interface; computing resources; design; digital; engineering design; expectation; experience; grasp; handheld mobile device; improved; indexing; innovation; instrument; kinematics; mobile application; mobile computing; neuroregulation; neurotransmission; next generation; novel; operation; programs; prototype; relating to nervous system; satisfaction; signal processing; usability

1 Intracortical neural interfaces, which record and analyze streams of neural signals recorded 2 from arrays of electrodes implanted in the brain, can enable fast, accurate, intuitive control of 3 enabling assistive technologies for individuals with paralysis arising from spinal cord injury as 4 well as other neurological conditions including stroke and ALS. Individuals with tetraplegia in the 5 pilot clinical trial of the BrainGate (IDE*) intracortical neural interface system use imagined 6 movements of their own paralyzed hand and arm to command point-and-click with a computer 7 cursor (on-screen typing, communication apps such as chat, web browsing) and to control 8 assistive devices including the DEKA prosthetic arm/hand, assistive robots and even reach and 9 grasp with one’s own paralyzed limb reanimated through patterned stimulation of the paralyzed 10 muscles. These BrainGate activities take place in study participants’ homes, but the need for a 11 recording cable tethered between the participant and a large rack of signal processing 12 computers dictates that the iBCI can only be used under direct technical supervision during 13 dedicated research periods. However, with the recent availability of a high-bandwidth, miniature 14 wireless neural signal transmitter (to eliminate the tethering cable) and a state-of-the-art 15 compact signal processing device with sufficient computational resources to execute the 16 BrainGate algorithms, the components are available to enable trial participants and caregivers 17 to use and administer a wireless, mobile intracortical brain-computer interface (iBCI) at home to 18 enable on-demand digital access throughout day and night and throughout the home. 19 This study aims to evaluate the feasibility and utility of an iBCI deployed in a mobile package 20 for independent use at home without technical supervision. In addition to evaluating the new 21 mobile platform, this will demonstrate the first-ever in-home use of an intracortical BCI without 22 direct technical oversight. End users and caregivers will be trained to configure and operate the 23 iBCI. With the iBCI mounted to their wheelchair and a chair-mounted consumer tablet, end 24 users with tetraplegia will be able to use their own imagined arm and hand movements to 25 control familiar tablet “apps” on demand anywhere in the home. Moving the mobile iBCI to the 26 bedside will enable tablet use from bed or neural signal monitoring through the night. 27 Before deployment, the current prototype mobile iBCI - developed in recent VA funded 28 research - will be provisioned with the most recent state-of-the-art signal processing and neural 29 decoding algorithms developed in the BrainGate pilot clinical trial. This will involve translating 30 those real-time software algorithms into hardware description language to program the ultra- 31 low-power System-on-Chip device. Recent algorithms to be incorporated will enable rapid, 32 automatic calibration of the BCI without expert intervention; maintain calibration over longer 33 periods of time to reduce the need for explicit recalibration steps; and improve the speed and 34 accuracy of cursor trajectories derived from the user’s neural signals. Each of three users will 35 evaluate the system over a continuous 5 to 10 day period, and repeat the home assessment in 36 at least 3 consecutive months. Throughout, the technical operation of the BCI system and the 37 BrainGate algorithms will be monitored and evaluated quantitatively. In addition, user and 38 caregivers will complete questionnaires measuring their evolving satisfaction with the system 39 and its utility. Analyses of these cumulative data will inform future device improvements. 40 *CAUTION:Investigational Device.Limited by Federal (United States) Law to Investigational Use

1个心脏内神经界面，记录和分析记录的神经信号流 2来自植入大脑的电极阵列，可以快速，准确，直观的控制 3为脊髓损伤引起的麻痹的个体启用辅助技术 4以及其他神经系统疾病，包括中风和ALS。患有四方的人 5布雷格酸盐（IDE*）心脏内神经界面系统的使用临床试验的使用 6个自己瘫痪的手和手臂的动作，用计算机指挥点击 7光标（屏幕上键入，通信应用程序，例如聊天，网络浏览）并控制 8种辅助设备，包括Deka假肢/手，辅助机器人，甚至到达， 9抓住自己的瘫痪的肢体通过瘫痪的图案刺激而复活 10个肌肉。这些紫罗兰活动是在研究参与者的家中进行的，但需要 11记录电缆在参与者和大量信号处理之间束缚 12台计算机规定，IBCI只能在直接技术监督下使用 13个专用研究期。但是，随着最近的高宽宽，微型的可用性 14无线神经信号发射器（消除束缚电缆）和最先进的 15紧凑型信号处理设备，具有足够的计算资源来执行 16个Braingate算法，这些组件可用于启用审判参与者和护理人员 17在家中使用和管理一个无线移动的内部脑部计算机界面（IBCI） 18启用日夜和整个家庭的按需数字访问。 19本研究旨在评估部署在移动包装中的IBCI的可行性和实用性 20用于在家中独立使用而无需技术监督。除了评估新的 21移动平台，这将展示有史以来首次使用的内部BCI 22直接技术监督。最终用户和护理人员将接受培训以配置和操作 23 IBCI。 ibci安装在轮椅上，并安装在椅子上的消费平板电脑，结束 24个四边形的用户将能够使用自己的想象的手臂和手部动作 25控制熟悉的平板电脑“应用程序”按需在家中的任何地方。将移动ibci移至 26床边将使平板电脑从床或神经信号监测到整个夜晚的使用。 27部署前，当前的原型移动IBCI - 在最近的VA资助中开发 28研究 - 将提供最新的最新信号处理和神经 29在Braingate Pilot临床试验中开发的解码算法。这将涉及翻译 30这些实时软件算法中的硬件说明语言来编程超级 31个低功率系统在芯片设备上。最近要合并的算法将使快速， 32无需专家干预即可自动校准BCI；维持更长的校准 33个时期，以减少对重新校准步骤的需求；并提高速度和 34光标轨迹的准确性来自用户的神经信号。三个用户中的每一个都将 35在连续的5到10天内评估系统，然后重复房屋评估 36至少连续3个月。在整个过程中，BCI系统和 将对37个文明算法进行定量监测和评估。另外，用户和 38护理人员将完成衡量其对系统不断发展的满意的问卷 39及其实用程序。这些累积数据的分析将为未来的设备改进提供信息。 40 *谨慎：调查设备。联邦（美国）法律限制了调查用途