The IGNITE II CC: Engagement, Coordination, Demonstration, and Dissemination

IGNITE II CC：参与、协调、示范和传播

• 批准号: 10336157
• 负责人: Hrishikesh Chakraborty
• 金额: $ 29.6万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-22 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10336157
• 关键词: Address; Administrative Supplement; Atlases; Award; Biological; Cohort Studies; Collaborations; Collection; Communication; Communities; Data; Data Analyses; Data Discovery; Development; Disease; Education; Educational workshop; Funding; Genetic; Genomic medicine; Genomics; Geography; Goals; Health; Individual; Information Dissemination; Information Technology; International; Internet; Investments; Knowledge; Leadership; Link; Logistics; Maps; Metadata; Mission; Modeling; National Human Genome Research Institute; Office of Administrative Management; Online Systems; Parents; Positioning Attribute; Process; Productivity; Professional Organizations; Program Development; Public Health; Research; Research Support; Resources; Sampling; Series; Strategic Planning; Structure; Translational Research; Universities; career networking; catalyst; clinical care; cohesion; cohort; federated computing; human data; improved; interest; low and middle-income countries; meetings; outreach; population health; pragmatic trial; programs; social; social media; virtual; web platform; working group

Project Summary This administrative supplement is requested to support the needs for the IGNITE Pragmatic Trial Network Coordinating Center (IGNITE PTN CC, U01 HG010225) to assist the International HundredK+ Cohorts Consortium (IHCC), administratively supported by the Global Genomic Medicine Collaborative (G2MC), to focus on NHGRI’s interest in research on pressing public health questions that can uniquely be addressed by collaborative efforts of large international cohort studies. The IGNITE PTN CC will enable advancement of the IHCC through the following aims: Aim 1: To provide coordination, logistical, and process resources for the G2MC secretariat to a) support the successful completion of cross-cohort global scientific projects initiated in 2019-2021, b) provide ongoing operational support for the IHCC leadership teams, c) prepare and support global virtual and face to face meeting agendas and their logistics, d) continue to build a robust and interactive cohorts’ community, and e) complete and launch its 5-year strategic plan. Aim 2: To develop and implement information technology strategies for the IHCC to enable identification of cohorts for participation in cross- cohort scientific projects (i.e., cohort ‘discovery’), the sharing of expertise and scientific findings, and to grow the IHCC community. This aim will be accomplished through a) support of the IHCC Global Cohorts Data Atlas development, b) development of IHCC workshops and regular seminars, and c) web presence and outreach to the Duke University and broader scientific community. By accomplishing these aims, the G2MC secretariat will increase representation of ancestrally and geographically diverse cohorts in recently awarded projects and IHCC leadership teams by enriching involvement with cohorts in low resource settings (LRS) and low- and middle- income countries (LMICs) and building a cohesive and interactive cohorts community. This supplement will also identify cohorts for participation in cross-cohort projects through expansion of the IHCC Global Cohorts Data Atlas. The Atlas utilizes a federated data discovery model and harmonizes cohort level metadata via a portal for search and discovery of relevant human data. Cross-organizational initiatives will develop and disseminate shared standards and best practices with our network of professional organizations with similar missions [e.g., the Global Alliance for Genomics and Health (GA4GH) and the International Common Disease Alliance (ICDA)] thus optimizing our investments. Developing a planned series of educational forums for good scientific exchange of ideas and lessons learned will strengthen knowledge dissemination beyond the IGNITE PTN and IHCC. Dissemination of shared knowledge and communications to the broader scientific community will be accomplished through web-based strategies and social media channels. In summary, we will facilitate interactions between and among cohorts to create a global platform for translational research, informing the social, biological and genetic basis for disease to improve clinical care and population health.

项目摘要 要求这种行政补充来支持IGNITE务实试验网络的需求 协调中心（IGNITE PTN CC，U01 HG010225）协助国际二野+队列 由全球基因组医学协作（G2MC）在行政上支持的财团（IHCC）， 关注NHGRI对施加公共卫生问题的研究的兴趣，这些问题可以独特地解决 大型国际队列研究的协作努力。 IGNITE PTN CC将实现 IHCC贯穿以下目的：目标1：提供协调，后勤和处理资源 G2MC秘书处a）支持成功完成跨科罗特全球科学项目 2019-2021，b）为IHCC领导团队提供持续的运营支持，c）准备和支持 全球虚拟和面对面的会议议程及其后勤工作，d）继续建立强大而互动的 同伙社区，E）完成并启动其5年战略计划。目标2：开发和实施 IHCC的信息技术策略可以识别同伙参加交叉 队列科学项目（即“发现”队列），专业知识和科学发现的共享，并成长 IHCC社区。该目标将通过a）支持IHCC全球人群数据地图集来实现 开发，b）开发IHCC研讨会和常规半手，c）网络存在和宣传 杜克大学和更广泛的科学界。通过完成这些目标，G2MC秘书处将 在最近授予的项目和 IHCC领导团队通过丰富参与人群参与低资源设置（LRS）和低 - 和 中等收入国家（LMIC）并建立了一个有凝聚力和互动的人群社区。此补充 还将通过扩展IHCC Global来确定参与跨境项目的同伙 人群数据地图集。地图集使用联合数据发现模型，并协调队列级元数据 通过门户网站搜索和发现相关的人类数据。跨组织计划将发展和 与我们的专业组织网络传播共同的标准和最佳实践 任务[例如，全球基因组和健康联盟（GA4GH）和国际普通疾病 联盟（ICDA）]因此优化了我们的投资。建立一系列计划的教育论坛 思想和经验教训的科学交流将增强知识传播 PTN和IHCC。向更广泛的科学界传播共同的知识和沟通 将通过基于网络的策略和社交媒体渠道来完成。总而言之，我们将促进 队列之间和之间之间的互动，以创建一个全球转化研究平台，告知 疾病的社会，生物学和遗传基础，以改善临床护理和人口健康。