IGF::OT::IGF STEVEN YOUNG CONSULTING MEDICINAL CHEMISTRY CONSULTANT SUPPORT

IGF::OT::IGF STEVEN YOUNG 咨询药物化学顾问支持

• 批准号: 10329819
• 负责人: STEVEN YOUNG
• 金额: $ 4万
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-28 至 2021-02-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10329819
• 关键词: Address; Area; Chemical Structure; Chemistry; Clinical Research; Clinical Trials; Consult; Contractor; Contracts; Data; Development; Electronic Mail; Feedback; Hour; Individual; Investigational Drugs; Lead; Methodology; Pharmaceutical Chemistry; Pharmaceutical Preparations; Preparation; Process; Reporting; Research Contracts; Role; Services; Strategic Planning; Teleconferences; Telephone; Testing; Time; United States National Institutes of Health; Visit; Work; design; drug development; drug discovery; lead optimization; meetings; member; preclinical safety; programs; symposium

The Contractor shall provide this support while serving on NIH BPN Lead Development Teams. Lead Development Teams (LDT) meet for approximately two hours every one to two weeks via teleconference and each LDT project may require between three and ten hours weekly, inclusive of meeting and preparation time. The Contractor is expected to provide support services in a collaborative way. Lead Development Teams the Contractor is assigned to may work on a number of projects in the exploratory through preclinical safety stages. Some projects may proceed to investigational new drug (IND) and clinical trial stages. The Contractor shall provide consulting support services to the NIH Blueprint Neurotherapeutics Network in the area of Medicinal Chemistry Medicinal chemistry consultants will be expected to provide senior-level medicinal chemistry expertise and contribute feedback and guidance on projects to the NIH and to LDT members through conference calls and by email. The role of the medicinal chemistry consultant may include but is not limited to the following responsibilities and tasks: • Offer input on project milestones, target product profiles, and testing funnels • Provide feedback on chemical structures and processes proposed by a chemistry service contractor for each round of SAR • Evaluate SAR data on a weekly or biweekly basis. • Medicinal chemistry consultant may be asked to evaluate the potential tractability (including surrounding IP space) of a chemical structure for medicinal chemistry. Specific consulting responsibilities will depend on the expertise of the individual consultant and the needs of individual projects. • In partnership with other consultants, contractors, and the NIH staff, advise, strategically plan, and manage medicinal chemistry programs to facilitate exploratory chemistry, hit-to-lead, lead optimization, IND enabling, and clinical studies. • Serve as the medicinal chemistry expert in order to identify potential drug discovery and development challenges and suggest strategies to address these challenges. • Collaborate on design of investigative studies in support of NIH drug discovery and development projects. • Accompany NIH staff or visit, at BPN staff request, Contract Research Organizations [CRO] under contract to BPN. Inspect facilities and discuss appropriateness of CRO proposed methodology. Submit trip reports to BPN staff. • Facilitate Lead Development Team discussions via telephone and email regarding assigned drug medicinal chemistry.

承包商应在NIH BPN领先开发团队任职时提供此支持。领先开发团队（LDT）每年一次至两个星期通过电话会议开会大约两个小时，每个LDT项目每周都需要三到十个小时，包括会议和准备时间。 预计承包商将以协作的方式提供支持服务。领先的开发团队将通过临床前安全阶段分配承包商可以在探索性的许多项目中工作。一些项目可能会继续研究新药（IND）和临床试验阶段。 承包商应为药物化学领域的NIH蓝图神经疗法网络提供咨询支持服务 预计药物化学顾问将提供高级药物化学专业知识，并通过电话会议和电子邮件向NIH和LDT成员提供有关项目的反馈和指导。 医学化学顾问的作用可能包括但不限于以下职责： •提供项目里程碑，目标产品配置文件和测试渠道的输入 •提供有关化学服务承包商针对每一轮SAR提出的化学结构和过程的反馈 •每周或每两周评估SAR数据。 •可以要求药物化学顾问评估医学化学化学结构的潜在障碍性（包括周围的IP空间）。具体的咨询责任将取决于个人顾问的专业知识和各个项目的需求。 •与其他顾问，承包商和NIH员工合作，咨询，战略性地计划和管理医学化学计划，以促进探索性化学，命中率高，铅优化，IND启用和临床研究。 •作为医学化学专家，以确定潜在的药物发现和发展挑战，并提出解决这些挑战的策略。 •协作研究研究研究的设计，以支持NIH药物发现和开发项目。 •陪同NIH的工作人员或根据BPN员工要求，合同研究组织[CRO]与BPN合同。检查CRO提出的方法的设施和讨论适当性。向BPN员工提交旅行报告。 •通过电话和电子邮件促进有关指定药物医学化学的电子邮件讨论。