National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia Project

全国青少年至成人健康纵向研究（添加健康）：第六波认知和痴呆症早期危险因素项目

• 批准号: 10328574
• 负责人: Allison E Aiello
• 金额: $ 154.63万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-15 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10328574
• 关键词: Activities of Daily Living; Adolescence; Adolescent; Adult; Affect; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Behavioral; Biological; Biological Factors; Biological Markers; Biological Testing; Blood; Cognition; Cognitive; Collection; Communities; Companions; Country; Coupled; Data; Data Collection; Development; Diabetes Mellitus; Drug usage; Early Intervention; Early identification; Economics; Elderly; Foundations; Future; Gait; Goals; Gold; Health; Health and Retirement Study; Hearing; Hypertension; Impaired cognition; Lead; Life Cycle Stages; Longitudinal Studies; Measurement; Measures; Nerve Degeneration; Obesity; Online Systems; Participant; Pathway interactions; Persons; Physical Function; Physical assessment; Population; Protocols documentation; Research; Research Personnel; Risk; Risk Factors; Risk Marker; Sampling; Scientific Advances and Accomplishments; Sensory; Signs and Symptoms; Smell Perception; Smoking; Surveys; Symptoms; Testing; Time; United States; Validation; Venous; Vision; aging population; base; behavioral health; cognitive function; cognitive testing; cohort; dementia risk; early adolescence; ethnic diversity; experience; health disparity populations; innovation; instrument; middle age; physically handicapped; prevent; prospective; racial and ethnic; response; social; trend

Project Summary Alzheimer's Disease and Related Dementias (ADRD) are projected to affect 14 million Americans by 2050. To date, though, research on the signs and symptoms of ADRD has been sparse in early midlife populations, especially at the national level. It is crucial to conduct such research because early changes in cognitive functioning and the accumulation of risk factors for ADRD can begin decades before concrete signs and symptoms emerge. The challenging search for the causes of ADRD has made it clear that prospective and comprehensive data—including detailed social, biological, and health measurements across the life course— are needed to identify key predictors of ADRD. As such, the National Longitudinal Study of Adolescent to Adult Health (Add Health) provides an extraordinary opportunity to study the early origins of cognitive functioning/change and ADRD risk in a nationally representative cohort that has been followed since adolescence and will be in their mid-40s in the next wave of data collection (Wave VI). The overall goal of this project is to collect and disseminate critical data related to cognitive, physical, and sensory functioning in conjunction with the Add Health Wave VI Core Project to facilitate identification of early risk factors for later life ADRD. Adding such rich measures to Wave VI of Add Health will make possible tracking of cognitive, sensory, and physical functioning across the life course; coupled with the testing of biological risk markers, it will also lay the foundation for detecting signs of cognitive impairment and ADRD risk in early midlife. These new data, when combined with Add Health's existing 25-year collection of extraordinarily rich multi-level and longitudinal measures and its new Wave VI data, will also aid in the scientific community's understanding of the interplay of social, behavioral, and biological factors leading to ADRD in later life. Moreover, because Add Health is a very diverse sample, adding these data to Wave VI will greatly increase understanding of cognitive, physical, and sensory functioning within health disparity populations. The project's specific aims are to: 1) Collect new in- depth, in-person assessments of cognitive functioning in early midlife for a nationally representative and racially/ethnically diverse subsample of participants in Wave VI; 2) Collect automated, (largely) web-based measures of cognition in early midlife for all participants in Wave VI and compare them with our in-person measures of cognition to assess their feasibility and value; 3) Include assessments of physical and sensory functioning in early midlife for Wave VI participants of Add Health; 4) Test for biological markers of ADRD risk and cognitive function in early midlife; 5) Clean, document, disseminate, promote, and support the data collected in this project for the scientific community. All told, this project will collect and disseminate innovative data to thousands of researchers that will facilitate the rigorous study of cognition and risk factors for later life ADRD among a diverse nationally representative sample of early midlife Americans.

项目摘要 阿尔茨海默氏病和相关痴呆症（ADRD）预计到2050年将影响1400万美国人。 但是，日期，对ADRD的体征和症状的研究在中年的早期人群中很少 特别是在国家一级。进行此类研究至关重要，因为认知的早期变化 在混凝土标志和 出现症状。挑战搜索ADRD的原因已经明确了这一潜在的和 全面的数据 - 包括整个生活课程的详细社会，生物学和健康测量 - 需要确定ADRD的关键预测指标。因此，全国青少年纵向研究成人 健康（Add Health）提供了一个非凡的机会来研究认知的早期起源 从那以后一直遵循的全国代表性队列中的功能/变化和ADRD风险 青少年将在下一波数据收集（Wave VI）中处于40年代中期。总体目标 项目是收集和传播与认知，身体和感觉功能有关的关键数据 与Add Add Health Wave VI核心项目的结合，以促进以后生命的早期风险因素 adrd。增加如此丰富的措施为ADD健康的波浪VI，将使认知，感觉， 以及整个生活过程中的身体功能；再加上生物风险标记的测试，它也将放置 在中年早年发现认知障碍和ADRD风险的迹象的基础。这些新数据， 与Add Health相结合的现有25年的非常丰富的多层次和纵向收集 措施及其新的Wave VI数据也将有助于科学界对 社会，行为和生物学因素导致后来的ADRD。而且，因为加健康非常 不同的样本，将这些数据添加到Wave VI中将大大增加对认知，物理和 健康差异人群中的感官功能。该项目的具体目的是：1）收集新的内部。 全国代表和中期的认知功能的深度，面对面评估 Wave VI参与者的种族/种族差异子样本； 2）收集自动化，（很大）基于Web Wave VI的所有参与者的早年中年认知措施，并将其与我们的面对面进行比较 认知措施评估其可行性和价值； 3）包括对身体和感觉的评估 在中期的早期工作，为VI的Pave VI参与者增加健康； 4）测试ADRD风险的生物标记 和中年早期的认知功能； 5）清洁，文档，传播，促进和支持数据 在该项目中为科学界收集。总而言之，这个项目将收集和传播创新 向数千名研究人员的数据，这些研究人员将促进对以后生活的认知和危险因素的严格研究 在全国范围内的中年化美国人的各种代表性样本中。