National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia Project

全国青少年至成人健康纵向研究（添加健康）：第六波认知和痴呆症早期危险因素项目

• 批准号: 10328574
• 负责人: Allison E Aiello
• 金额: $ 154.63万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-15 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10328574
• 关键词: Activities of Daily Living; Adolescence; Adolescent; Adult; Affect; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Behavioral; Biological; Biological Factors; Biological Markers; Biological Testing; Blood; Cognition; Cognitive; Collection; Communities; Companions; Country; Coupled; Data; Data Collection; Development; Diabetes Mellitus; Drug usage; Early Intervention; Early identification; Economics; Elderly; Foundations; Future; Gait; Goals; Gold; Health; Health and Retirement Study; Hearing; Hypertension; Impaired cognition; Lead; Life Cycle Stages; Longitudinal Studies; Measurement; Measures; Nerve Degeneration; Obesity; Online Systems; Participant; Pathway interactions; Persons; Physical Function; Physical assessment; Population; Protocols documentation; Research; Research Personnel; Risk; Risk Factors; Risk Marker; Sampling; Scientific Advances and Accomplishments; Sensory; Signs and Symptoms; Smell Perception; Smoking; Surveys; Symptoms; Testing; Time; United States; Validation; Venous; Vision; aging population; base; behavioral health; cognitive function; cognitive testing; cohort; dementia risk; early adolescence; ethnic diversity; experience; health disparity populations; innovation; instrument; middle age; physically handicapped; prevent; prospective; racial and ethnic; response; social; trend

Project Summary Alzheimer's Disease and Related Dementias (ADRD) are projected to affect 14 million Americans by 2050. To date, though, research on the signs and symptoms of ADRD has been sparse in early midlife populations, especially at the national level. It is crucial to conduct such research because early changes in cognitive functioning and the accumulation of risk factors for ADRD can begin decades before concrete signs and symptoms emerge. The challenging search for the causes of ADRD has made it clear that prospective and comprehensive data—including detailed social, biological, and health measurements across the life course— are needed to identify key predictors of ADRD. As such, the National Longitudinal Study of Adolescent to Adult Health (Add Health) provides an extraordinary opportunity to study the early origins of cognitive functioning/change and ADRD risk in a nationally representative cohort that has been followed since adolescence and will be in their mid-40s in the next wave of data collection (Wave VI). The overall goal of this project is to collect and disseminate critical data related to cognitive, physical, and sensory functioning in conjunction with the Add Health Wave VI Core Project to facilitate identification of early risk factors for later life ADRD. Adding such rich measures to Wave VI of Add Health will make possible tracking of cognitive, sensory, and physical functioning across the life course; coupled with the testing of biological risk markers, it will also lay the foundation for detecting signs of cognitive impairment and ADRD risk in early midlife. These new data, when combined with Add Health's existing 25-year collection of extraordinarily rich multi-level and longitudinal measures and its new Wave VI data, will also aid in the scientific community's understanding of the interplay of social, behavioral, and biological factors leading to ADRD in later life. Moreover, because Add Health is a very diverse sample, adding these data to Wave VI will greatly increase understanding of cognitive, physical, and sensory functioning within health disparity populations. The project's specific aims are to: 1) Collect new in- depth, in-person assessments of cognitive functioning in early midlife for a nationally representative and racially/ethnically diverse subsample of participants in Wave VI; 2) Collect automated, (largely) web-based measures of cognition in early midlife for all participants in Wave VI and compare them with our in-person measures of cognition to assess their feasibility and value; 3) Include assessments of physical and sensory functioning in early midlife for Wave VI participants of Add Health; 4) Test for biological markers of ADRD risk and cognitive function in early midlife; 5) Clean, document, disseminate, promote, and support the data collected in this project for the scientific community. All told, this project will collect and disseminate innovative data to thousands of researchers that will facilitate the rigorous study of cognition and risk factors for later life ADRD among a diverse nationally representative sample of early midlife Americans.

项目概要 预计到 2050 年，阿尔茨海默病和相关痴呆症 (ADRD) 将影响 1,400 万美国人。 然而，迄今为止，关于 ADRD 体征和症状的研究在中年早期人群中还很少， 尤其是在国家层面进行此类研究至关重要，因为认知的早期变化。 ADRD 的功能和风险因素的积累可能在具体迹象和出现之前几十年就开始了。 对 ADRD 原因的富有挑战性的探索已经清楚地表明，前瞻性和 全面的数据——包括整个生命过程中详细的社会、生物和健康测量—— 需要确定 ADRD 的关键预测因素，因此，需要进行国家青少年至成人纵向研究。 健康（Add Health）为研究认知的早期起源提供了绝佳的机会 自此以来一直跟踪的具有全国代表性的队列中的功能/变化和 ADRD 风险 下一波数据收集（第六波）的总体目标是青春期和 40 多岁。 项目的目的是收集和传播与认知、身体和感觉功能相关的关键数据 与 Add Health Wave VI 核心项目结合，促进识别晚年的早期风险因素 ADRD 将如此丰富的测量添加到 Add Health 的 Wave VI 中，将使跟踪认知、感觉、 以及整个生命过程中的身体机能；再加上生物风险标记的测试，它也将奠定基础。 这些新数据为检测中年早期认知障碍和 ADRD 风险的迹象奠定了基础。 与 Add Health 现有的 25 年极其丰富的多层次和纵向收藏相结合 措施及其新的 Wave VI 数据也将有助于科学界理解 此外，社会、行为和生物因素导致晚年出现ADRD，因为添加健康是一个非常重要的因素。 多样化的样本，将这些数据添加到 Wave VI 将大大增加对物理和 该项目的具体目标是： 1) 收集新的信息。 对具有全国代表性的中年早期认知功能进行深度、面对面的评估 Wave VI 参与者的种族/民族多样化子样本；2) 收集自动化（主要）基于网络的样本； 对第六波浪潮中所有参与者的中年早期认知测量进行测量，并将其与我们现场进行比较 3) 包括身体和感官评估 Add Health 第六波参与者在中年早期发挥功能；4) 测试 ADRD 风险的生物标志物 5）清理、记录、传播、推广和支持数据 总而言之，该项目将收集并传播创新成果。 向数千名研究人员提供数据，这将有助于对晚年认知和风险因素进行严格研究 ADRD 是美国中年早期具有全国代表性的多元化样本。