Noninvasive transcranial detection of intracranial hemorrhage using a tri-coil handheld portable eddy current damping imaging device

使用三线圈手持式便携式涡流阻尼成像装置对颅内出血进行无创经颅检测

• 批准号: 10329954
• 负责人: Gabriel Zada
• 金额: $ 38.9万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-15 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10329954
• 关键词: Address; Affect; Alteplase; American; American Heart Association; Anatomic Models; Brain; Brain hemorrhage; Cadaver; Cause of Death; Cerebral hemisphere hemorrhage; Cerebrum; Cessation of life; Characteristics; Clinical; Coma; Confusion; Consumption; Data; Detection; Deterioration; Devices; Diagnosis; Diagnostic; Diagnostic Imaging; Dose; Effectiveness; Frequencies; Gelatin; Goals; Grouping; Guidelines; Health system; Hemorrhage; Hospitals; Hour; Human; Image; Image Analysis; Imaging Device; Injury; Institutional Review Boards; International; Intervention; Intracranial Hemorrhages; Ischemic Stroke; Joints; Journals; Knowledge; Lesion; Life; Location; Magnetic Resonance Imaging; Measures; Medical; Medical Device; Methods; Modeling; Morbidity - disease rate; Nervous System Trauma; Neurologic; Neurological emergencies; Neurosurgeon; Outcome; Output; Participant; Patients; Pharmaceutical Preparations; Physicians; Pre-Clinical Model; Productivity; Property; Protocols documentation; Provider; Publishing; Quality of life; Reporting; Savings; Scanning; Scientist; Shapes; Societies; Stroke; Technology; Testing; Time; Tissues; Translating; Translational Research; Traumatic Brain Injury; Triage; United States National Institutes of Health; Validation; Variant; X-Ray Computed Tomography; acute care; base; brain parenchyma; brain tissue; clinical investigation; cost; cranium; detection platform; diagnostic accuracy; diagnostic value; disability; disorder subtype; experience; experimental study; imaging detection; imaging system; improved; innovation; instrument; ischemic lesion; laboratory experiment; machine learning algorithm; magnetic field; meetings; method development; models and simulation; mortality; multidisciplinary; neuroimaging; non-invasive imaging; novel; portability; predictive modeling; rapid technique; research clinical testing; response; sensor; stroke model; stroke patient; stroke therapy; symposium; temporal measurement

Project Summary: Noninvasive transcranial detection of intracranial hemorrhage using a tri-coil handheld portable eddy current damping imaging device Stroke and traumatic brain injury (TBI) are common causes of death and permanent disability worldwide, costing the U.S. health system more than $71 billion per year in lost productivity and medical expenses. Existing paradigms for stroke/TBI diagnosis require computed tomography (CT) or magnetic resonance (MR) imaging to classify ischemic versus hemorrhagic variants prior to intervention, as treatment for these conditions varies widely. Delays in diagnosis and issues related to transport of unstable patients associated with diagnostic imaging increase the likelihood of neurological injury and death. Translational medical devices that accelerate time-to-treatment in the field or hospital setting may help to reduce morbidity and mortality in stroke/TBI patients on a global level. Our team has developed a portable, rapid and noninvasive imaging and detection device based on eddy current damping (ECD) sensors that can detect brain hemorrhages associated with stroke and TBI, and have demonstrated feasibility in a benchtop, human cadaver and clinical patient setting. This device can potentially diagnose and classify hemorrhagic stroke/TBI subtypes with accurate spatial localization in minutes, rather than hours, thereby guiding early responders and medical providers in making time-sensitive medical decisions for clinical intervention, such as administration of tissue plasminogen activator for ischemic stroke. Our overall goal is to demonstrate the effectiveness of this novel stroke detection device in rapidly triaging stroke/TBI patients and achieving a level of diagnostic accuracy capable of guiding clinical intervention. We hypothesize that: 1) Regional conductivity changes in brain tissue can be imaged and detected using the portable ECD sensor; 2) Hemorrhagic stroke and TBI-related hemorrhages will increase regional conductivity, whereas ischemic stroke will decrease dependent brain conductivity in affected ischemic regions; and 3) Portable stroke imaging may reduce time-to-treatment and diagnosis associated with stroke/TBI. To test these hypotheses, we aim to: 1) Perform benchtop laboratory experiments to further elucidate how direction and magnitude of measured conductivity changes can differentiate stroke subtype and location, 2) Use validated human cadaver stroke simulation models to optimize ECD tri-coil array sensor detection of hemorrhage depth, volume, and location, 3) Utilize machine learning algorithms to quickly classify brain lesions with high accuracy, and 4) Implement early clinical stroke/TBI ECD sensor device testing to gauge effectiveness in live human patients, compared to CT/MR imaging. Development of methods for rapid bedside stroke/TBI diagnosis will provide practitioners with knowledge required to rapidly administer life-saving treatments, thereby improving patient quality of life and survival. Knowledge derived from this will help to reduce time-to-treatment and guide triage and intervention, which is likely to translate to improved morbidity and mortality associated with these common conditions.

项目摘要：使用三层手持的颅内出血的无创颅检测 便携式涡流阻尼装置 中风和创伤性脑损伤（TBI）是全球死亡和永久残疾的常见原因，成本为 美国卫生系统每年的生产力和医疗费用损失超过710亿美元。现存的 中风/TBI诊断的范例需要计算机断层扫描（CT）或磁共振（MR）成像 干预前的缺血性变体与出血性变体分类，因为这些疾病的治疗有所不同 广泛。与诊断相关的不稳定患者的运输有关的诊断延迟和问题 成像增加了神经损伤和死亡的可能性。加速的转化医疗设备 现场或医院环境中治疗的时间可能有助于降低中风/TBI患者的发病率和死亡率 在全球范围内。我们的团队开发了一种基于便携式，快速且无创的成像和检测设备 关于可以检测与中风和TBI相关的脑出血的涡流阻尼（ECD）传感器 在台式，人尸体和临床患者环境中表现出可行性。该设备可以 有可能在几分钟内与准确的空间定位对出血性中风/TBI亚型进行分类 从而指导早期响应者和医疗提供者进行时间敏感的医学，而不是数小时 临床干预的决策，例如用于缺血性中风的组织纤溶酶原激活剂。我们的 总体目标是证明这种新型中风检测装置在快速分盘/TBI中的有效性 患者并达到能够指导临床干预的诊断准确性水平。我们假设 那就是：1）可以使用便携式ECD对脑组织的区域电导率变化进行成像和检测 传感器; 2）出血性中风和与TBI相关的出血将增加区域电导率，而 缺血性中风会降低受影响的缺血区域的依赖性大脑电导率； 3）便携式中风 成像可能会减少与中风/TBI相关的时间处理时间和诊断。为了检验这些假设，我们 目的是：1）执行台式实验室实验，以进一步阐明方向和大小如何 测得的电导率变化可以区分卒中亚型和位置，2）使用经过验证的人尸体 中风仿真模型以优化ECD三层阵列阵列传感器检测出血深度，体积和 位置，3）利用机器学习算法以高精度快速对脑病变进行分类，4） 实施早期临床中风/TBI ECD传感器设备测试以衡量现场人体患者的有效性， 与CT/MR成像相比。开发快速床头中风/TBI诊断的方法将提供 具有迅速管理救生治疗所需知识的从业者，从而改善患者 生活质量和生存。从中得出的知识将有助于减少处理时间和指导分类 和干预措施，这可能会转化为改善与这些共同的发病率和死亡率 状况。