Angiotensinogen originating from liver by glomerular filtration pressure is involved in circadian rhythm of intrarenal renin-angiotensin system.

血管紧张素原通过肾小球滤过压从肝脏产生，参与肾内肾素-血管紧张素系统的昼夜节律。

• 批准号: 17K09693
• 负责人: Ohashi Naro
• 金额: $ 3万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09693/
• 关键词: 腎臓内レニン-アンジオテンシン系; アンジオテンシノーゲン; 糸球体濾過圧; 日内変動; in vivo imaging; 糸球体濾過値; 糸球体過剰濾過

项目成果

Salt Loading Aggravates the Relationship between Melatonin and Proteinuria in Patients with Chronic Kidney Disease

盐负荷加重慢性肾病患者褪黑素与蛋白尿的关系

• DOI: 10.2169/internalmedicine.1929-18
• 发表时间: 2019
• 影响因子: 1.2
• 作者: Ohashi N; Ishigaki S; Isobe S; Matsuyama T; Sato T; Fujikura T; Tsuji T; Kato A; Yasuda H.
• 通讯作者: Yasuda H.

Increased heart rate is associated with intrarenal renin-angiotensin system activation in chronic kidney disease patients.

慢性肾病患者的心率增加与肾内肾素-血管紧张素系统激活有关。

• DOI: 10.1007/s10157-019-01746-1
• 发表时间: 2019
• 影响因子: 2.3
• 作者: Ohashi N; Isobe S; Ishigaki S; Aoki T; Matsuyama T; Sato T; Fujikura T; Kato A; Yasuda H.
• 通讯作者: Yasuda H.

The Urinary Angiotensinogen to Urinary Albumin Ratio Reflects Whether the Renin-angiotensin System in the Kidney Is Activated due to Filtration of Plasma Angiotensinogen through the Damaged Glomeruli or the Production of Angiotensinogen in the Proximal Tu

尿血管紧张素原与尿白蛋白的比率反映了肾脏中的肾素-血管紧张素系统是否由于血浆血管紧张素原通过受损肾小球的过滤或近端血管中血管紧张素原的产生而被激活。

• DOI: 10.2169/internalmedicine.3624-19
• 发表时间: 2020
• 影响因子: 1.2
• 作者: Ohashi N; Aoki T; Matsuyama T; Ishigaki S; Isobe S; Katahashi N; Sato T; Fujikura T; Kato A; Yasuda H.
• 通讯作者: Yasuda H.

Increased heart rate reflects intrarenal renin-angiotensin system activation in chronic kidney disease patients but not in subjects without chronic kidney disease.

心率增加反映了慢性肾病患者肾内肾素-血管紧张素系统的激活，但在没有慢性肾病的受试者中则不然。

• 发表时间: 2019
• 作者: Ohashi N; Isobe S; Ishigaki S; Aoki T; Matsuyama T; Sato T; Fujikura T; Kato A
• 通讯作者: Kato A

Chronotherapy of renin-angiotensin system (RAS) inhibitor ameliorates renal damage via suppression of intrarenal RAS activity.

肾素-血管紧张素系统 (RAS) 抑制剂的计时疗法通过抑制肾内 RAS 活性来改善肾损伤。

• 发表时间: 2019
• 作者: Aoki T; Ohashi N; Isobe S; Ishigaki S; Matsuyama T; Fujikura T; Kato A; Yasuda H.
• 通讯作者: Yasuda H.