Pediatric Heart Network Prairieland Consortium

儿科心脏网络 Prairieland 联盟

• 批准号: 10318624
• 负责人: James Cnota
• 金额: $ 34.32万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10318624
• 关键词: Adult; Americas; Area; Basic Science; Bioinformatics; Biological; Cardiology; Cardiovascular system; Caring; Child; Childhood; Clinic; Clinical; Clinical Research; Clinical Research Protocols; Clinical Services; Clinical Trials; Collaborations; Communication; Congenital Abnormality; Data; Data Coordinating Center; Development; Diagnosis; Echocardiography; Enrollment; Faculty; Genetic; Goals; Health; Health Service Area; Heart; Heart Diseases; Hospitals; Illinois; Image; Indiana; Industry; Infrastructure; Institution; Institutional Review Boards; Investigation; Kentucky; Longitudinal cohort; Longterm Follow-up; Maps; Medical center; Medicine; Methodology; Midwestern United States; Mission; Multi-Institutional Clinical Trial; National Heart, Lung, and Blood Institute; Ohio; Online Systems; Operative Surgical Procedures; Patient Recruitments; Patients; Pediatric Hospitals; Persons; Population; Population Heterogeneity; Problem Solving; Process; Protocols documentation; Records; Research; Research Personnel; Resources; Sampling; Schedule; Site; Teleconferences; Translational trial; United States National Institutes of Health; Universities; Visit; West Virginia; bioinformatics infrastructure; biomedical referral center; clinical center; clinical research site; cohort; college; data management; electronic data; experience; follow-up; improved; industry partner; innovation; medical schools; meetings; member; novel therapeutics; patient population; programs; protocol development; recruit; repository; social media; success; surgery outcome; surgical service; tertiary care; young adult

Project summary This competing renewal application aims to demonstrate that the Prairieland Consortium (PC) has the patient population, faculty and staff expertise, clinical services, research resources, and enrollment and follow-up successes to continue as an outstanding and productive member of the NHLBI’s Pediatric Heart Network. The PC is unique in that it is comprised of two pediatric cardiovascular programs located at Cincinnati Children’s Hospital Medical Center (CCHMC) in Cincinnati, OH, and Riley Hospital for Children (RHC), in Indianapolis, IN. This consortium is led by an established collaboration between Dr. James F. Cnota at the University of Cincinnati College of Medicine, and Dr. R. Mark Payne at Indiana University School of Medicine. Together, the institutions are responsible for more than 1,000 cardiothoracic surgeries, >14,000 patient visits, and >20,000 in-house echocardiograms per year. Unique features of this collaboration include a large and diverse population in the heartland of America for recruitment and enrollment into clinical studies, strong CTSA’s at both institutions supporting the infrastructure, excellent and collaborative clinical research coordinator teams, established and robust bioinformatics infrastructures, and meaningful integration of clinical cardiology, basic science, and surgical services at both sites. In Aim 1, we will utilize our pediatric and ACHD clinics to recruit and enroll subjects into approved PHN protocols, and support long-term cohort follow-up. We will pursue high enrollment rates, and collect patient data and samples per approved protocols. We will rapidly enter de- identified electronic data and deliver biological samples to PHN repositories to meet Network goals and standards. In Aim 2, we will develop and implement research protocols for clinical and translational trials. Our 2 centers will continue to hold frequent scheduled videoconferences and in-person meetings to generate new ideas, data, and protocols for submission to the NIH and PHN for consideration. In particular, we will include our strong cardiovascular genetic and basic science colleagues in these discussions to develop new clinical and translational protocols. We will utilize our respective CTSA’s to help develop and pilot preliminary studies that will be used to generate full protocols for submission to the PHN. We will continue actively to participate in PHN meetings and committees, protocol review and development, industry and NIH sponsored trials, and educational missions of the PHN. The long-term goal of our participation in the PHN is to advance the care and understanding of children with congenital and acquired heart disease. The Prairieland Consortium is eager to continue its collaboration with other clinical centers, the data-coordinating center (NERI), the NHLBI staff, and industry partners to complete ongoing studies and initiate innovative new investigations.

项目摘要 该竞争性更新申请旨在证明大草原财团（PC）有病人 人口，教职员工和员工专业知识，临床服务，研究资源以及入学和随访 成功成为NHLBI小儿心脏网络的杰出成员 PC的独特之处在于它由辛辛那提儿童的两个小儿心脏病性心血管节目组成 俄亥俄州辛辛那提市的医院医疗中心（CCHMC）和印第安纳波利斯的莱利儿童医院（RHC）。 该财团由ET大学的James F. Cnota博士之间的合作领导 辛辛那提医学院和印第安纳大学医学院的R. R. R. Mark Payne博士。 机构负责1,000多次心胸外科手术，> 14,000例患者访问和> 20,000 内部超声心动图珀斯一年。 美国心脏地带的人口招募和入学临床研究，强大的CTSA's 这两个学院都支持基础设施，出色和协作的临床研究协调员团队， 建立且强大的生物信息学基础设施，以及临床心脏病学的局势整合，基本 在AIM 1中的科学和外科服务。 并将受试者纳入批准的PHN方案，并支持长期的队列随访。 注册率，并根据批准的协议收集患者数据和样本。 识别电子数据并将生物样品交付给PHN存储库，以满足网络目标和 在AIM 2中，我们将开发和实施用于临床和转化试验的研究方案 中心将继续举办频繁的预定视频会议和面对面的会议，以生成新的 提交NIH和PHN的想法，数据和协议，特别是我们将包括 我们在TESE中的强大心血管遗传和基础科学同事讨论了开发新的临床 和翻译协议。 这将是为了提交PHN的完整协议。 PHN会议和委员会，协议审查与发展，行业和NIH赞助的试验，以及 PHN的教育任务。 了解先天性和心脏病的儿童。 继续与其他临床中心，数据协调中心（NERI），NHLBIFF和和和 行业合作伙伴完成研究并启动创新的新调查。