Addressing Tetrachloroethylene Exposure in an Impacted Community: Residents' Concerns, Neurotoxic Effects, and Exposure Reduction

解决受影响社区的四氯乙烯暴露问题：居民的担忧、神经毒性作用和减少暴露

• 批准号: 10312448
• 负责人: SA LIU
• 金额: $ 61.37万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-12 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10312448
• 关键词: Address; Adult; Assessment tool; Authorization documentation; Awareness; Biological; Breathing; Carbon; Cognitive; Communities; Community Health; County; Data; Data Analyses; Decision Making; Development; Disadvantaged; Education; Effectiveness; Environmental Health; Evaluation; Excision; Exhalation; Exposure to; Filtration; Focus Groups; Goals; Group Interviews; Hazardous Waste Sites; Health; Health Status; Home; Incidence; Indiana; Individual; Indoor Air Pollution; Industrialization; Industry; Information Centers; Investigation; Legal; Legal Liability; Linear Regressions; Link; Malignant Neoplasms; Measures; Metals; Methodology; Modeling; Multimedia; Municipalities; Neurocognitive; Occupational Exposure; Pathway interactions; Perception; Persons; Poison; Process; Property; Protons; Public Health; Reaction Time; Recording of previous events; Reporting; Research; Resources; Risk; Risk Assessment; Sampling; Site; Soil; Solvents; Surveys; System; Testing; Tetrachloroethylene; Theory of Change; Time; Trichloroethylene; United States Environmental Protection Agency; Vision; Visual; Waste Management; Water; Work; base; cancer risk; citizen science; cognitive function; community engaged research; community living; data registry; design; disease registry; drinking water; effectiveness evaluation; environmental justice; evidence base; exposed human population; ground water; home test; improved; indoor air; mass spectrometer; member; migration; minimal risk; neoplasm registry; neurotoxic; neurotoxicity; operation; primary endpoint; programs; recruit; remediation; response; success; superfund site; tool; vapor intrusion; volatile organic compound

Project Summary We propose to develop a community engaged research program in Martinsville, IN, a community of 11,000 people that overlays four groundwater contamination sites, including a U.S. Environmental Protection Agency- designated Superfund site. The total size of the groundwater contamination is over 60 acres and lies within a single aquifer. The contaminants are chlorinated volatile organic compounds (CVOCs), primarily tetrachloroethylene (PCE) and trichloroethylene (TCE), thought to originate from several dry cleaning and metal degreasing operations. An activated carbon filtration system has been in operation since 2005 to remove PCE/COVCs from the municipal water, which now meets EPA drinking water standards. However, a recent report from the Agency for Toxic Substances and Disease Registry concludes that people’s health may be harmed by breathing indoor air contaminated via vapor intrusion, the migration of volatile compounds from contaminated groundwater and soil into buildings above. The long-term goal of our research is to understand health effects of PCE exposure in communities, and to empower community members’ participation in environmental health decision-making. The project will be led by a transdisciplinary academic team in a strong partnership with two community based organizations. This team will partner with an existing, engaged Community Advisory Board (CAB), to accomplish three aims. Aim 1 will assess the community’s concerns and perceptions about the contamination and associated health risks, and how that changes across the 5-year project. Aim 2 will quantify current exposure to PCE/CVOCs in exhaled breath and indoor air from 300 residents using a cutting edge assessment tool, proton transfer reaction time-of-flight mass spectrometer (PTR-TOF-MS). Through modeling we will estimate cumulative exposures in residents and investigate associations of CVOC mixtures with visual and cognitive functions, which are hypothesized to be a sensitive non-cancer endpoint for PCE exposure. We will also address the community’s concerns about elevated cancer rates using Indiana state cancer registry data. In Aim 3, we will design and implement a targeted educational campaign to promote PCE/CVOC testing and installation of mitigation systems when residential contamination levels exceed exposure limits, with a focus on promoting property owners’ and landlords’ participation in vapor intrusion testing and remediation activities. With the CAB, we will co-design the action plan, identifying and responding to emerging barriers, through a Developmental Evaluation (DE) process utilizing a Theory of Change (TOC) model informed by the evaluation team’s qualitative and quantitative analysis of data on stakeholder concerns and responses. Throughout the process of community assessment and education, we will evaluate the effectiveness of the process, identifying pathways for moving from research to effective actions.

项目摘要 我们建议在印第安纳州马丁斯维尔开发一个社区参与研究计划，一个11,000的社区 覆盖四个地下水污染地点的人们，包括美国环境保护署 - 指定的超级基金网站。地下水污染的总尺寸超过60英亩，位于 单含水层。污染物是氯化挥发性有机化合物（CVOC），主要 四氯乙烯（PCE）和三氯乙烯（TCE），源自几种干洗和 金属脱脂操作。自2005年以来，活性炭过滤系统一直在运行 来自市政水的PCE/COVC现在符合EPA饮用水标准。但是，最近 有毒物质和疾病注册机构的报告得出结论，人们的健康可能是 受呼吸室内空气受到的伤害，通过蒸气侵入污染，挥发性化合物的迁移 将地下水和土壤污染到上面的建筑物中。我们研究的长期目标是了解 PCE暴露在社区中的健康影响，并增强社区成员的参与 环境健康决策。该项目将由一个强大的跨学科学术团队领导 与两个基于社区的组织合作。该团队将与现有的，参与的合作 社区咨询委员会（CAB），以实现三个目标。 AIM 1将评估社区的担忧，并且 对污染和相关健康风险的看法，以及在5年中如何变化 项目。 AIM 2将量化耗尽呼吸中的PCE/CVOC当前暴露于300的室内空气 居民使用尖端评估工具，质子转移反应飞机质谱仪 （PTR-TOF-MS）。通过建模，我们将估计居民的累积暴露并调查 CVOC混合物与视觉和认知功能的关联，假设是敏感的 PCE暴露的非癌端点。我们还将解决社区对升高癌症的担忧 使用印第安纳州癌症注册表数据的比率。在AIM 3中，我们将设计和实施有针对性的教育 住宅污染时促进PCE/CVOC测试和缓解系统的安装的运动 水平超过暴露限制，重点是促进业主和房东参与蒸气 入侵测试和补救活动。使用出租车，我们将共同设计行动计划，识别和 通过发展理论，通过发展评估（DE）处理新兴障碍 评估团队对数据的定性和定量分析告知的变更（TOC）模型 利益相关者关注和回应。通过社区评估和教育的过程，我们 将评估该过程的有效性，确定从研究到有效的途径 动作。