Neural Mechanisms of Social Rejection elicited Aggression in Adolescence

社会拒绝的神经机制引发青春期的攻击行为

基本信息

批准号：
10313780
负责人：
Megan Quarmley
金额：
$ 3万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-11 至 2023-06-10
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10313780
关键词：
Active Learning Address Adolescence Adolescent Aggressive behavior Amygdaloid structure Anterior Anxiety Behavior Bipolar Disorder Brain Brain region Cause of Death Clinical Clinical Psychology Complex Country Data Dorsal Educational workshop Feedback Financial cost Foundations Functional Magnetic Resonance Imaging Funding Future Goals Grant Insula of Reil Link Measures Mediating Mental Depression Mental Health Mental disorders Mentorship Methodology Methods National Institute of Mental Health Neurobiology Neurocognitive Neuronal Plasticity Positioning Attribute Prefrontal Cortex Psychopathology Research Research Design Research Training Risk Schools Scientist Social Interaction Strategic Planning Symptoms Testing Time Training Universities Violence Work Youth anti social base behavioral study career cognitive control design experience implementation intervention intervention program method development neural network neural patterning neuroimaging neuromechanism novel peer peer influence prevent programs relating to nervous system response skills social success time use trait virtual

项目摘要

PROJECT SUMMARY/ABSTRACT Each year, violence in this country exacts staggering personal and financial costs. This burden is disproportionally born by adolescents, for whom violent behaviors linked to peer-based rejection are a leading cause of death. This may be related to the fact that peer relationships become highly salient in adolescence. Peer-based aggression is also a transdiagnostic symptom of several mental health disorders with high adolescent onset rates, and predicts risk for bipolar disorder, anxiety, and depression. Because adolescence is a sensitive period for neural plasticity, it is critical to identify neural mechanisms that bias youth towards perpetrating aggression before habitual antisocial tendencies are instantiated. Traditional intervention programs that target those at risk for perpetrating aggression have had only limited success. This may be because aggressive behavior is likely influenced by a complex cascade of neural responses that unfold across a social interaction. However, no study has examined these relations in adolescents, the group most impacted by peer-based aggression. Progress towards this goal has been hindered by the limited availability of ecologically-valid fMRI-based social interaction tasks that delineate temporal stages within a social interaction, such as anticipation and receipt of peer feedback, and contemplating aggression. The proposed work addresses these limitations by using a novel fMRI-based paradigm, the Virtual School and Aggression (VSA) task, to identify brain regions engaged at each temporal stage of a social interaction that predict aggressive behavior in adolescents (N=50; 11-15 years). I will also use time lapsed network interaction analyses, a novel form of functional connectivity analyses, to examine how the threat and cognitive control networks in the brain interact across distinct temporal stages as social rejection elicited aggression unfolds. Aims of this study are consistent with the NIMH strategic plan [(Objective 1): defining the mechanisms of complex behaviors, in this case, how social experiences and neural mechanisms influence peer-based aggressive behavior. The proposed study will determine both when during a social interaction regional brain function promotes aggressive behavior, and also how neural networks interact to promote social rejection elicited aggression. Such findings will provide novel treatment targets for aggressive behavior in youth. The proposed training plan, which consists of workshops, experiential learning, and mentorship, is designed to develop the applicant's expertise in the neurobiology of aggression, advanced neuroimaging methods, and the development and implementation of interventions for aggressive youth.] The proposed study will occur within Temple University's clinical psychology program, which has a successful track record of conducting impactful NIMH-funded research and training research scientists.

项目摘要/摘要每年，这个国家的暴力行为都会使个人和财务成本达到惊人。这个负担是青少年诞生的不成比例，与基于同行的拒绝相关的暴力行为是领先的死亡原因。这可能与同伴关系在青春期变得高度显着的事实有关。基于同伴的侵略也是多种精神健康障碍的转诊症状青少年发作率，并预测躁郁症，焦虑和抑郁症的风险。因为青春期是神经可塑性的敏感时期，至关重要的是确定神经机制使青年偏向于实例化在习惯反社会趋势之前进行侵略。传统干预针对有风险进行侵略的人的计划只有有限的成功。这可能是因为侵略行为可能受到一系列复杂的神经反应的影响社交互动。但是，尚无研究检查青少年的这些关系，该小组影响最大通过基于同伴的侵略。朝着这个目标的进展受到了有限的可用性的阻碍基于生态valid fmri的社会互动任务，这些任务在社会互动中描述了时间阶段，例如期待和接收同伴反馈，并考虑侵略。拟议的工作通过使用基于fMRI的新型范式，虚拟学校和侵略（VSA）来解决这些限制。任务，确定在社会互动的每个时间阶段参与的大脑区域，以预测积极进取青少年的行为（n = 50; 11 - 15年）。我还将使用时间段的网络交互分析，这是一种新颖的功能连接分析的形式，以检查大脑中的威胁和认知控制网络如何随着社会反应引起的侵略的展开，跨时间阶段相互作用。这项研究的目的是与NIMH战略计划一致[（目标1）：定义复杂行为的机制，在此中案例，社会经验和神经机制如何影响基于同伴的攻击行为。这拟议的研究将确定在社交互动期间区域脑功能促进的何时促进侵略行为，以及神经网络如何相互作用以促进社会反应引起侵略。这样的发现将为青年人的侵略性行为提供新的治疗目标。拟议的培训计划，由研讨会，经验学习和指导组成，旨在开发申请人的侵略性，高级神经影像学方法以及发展的神经生物学专业知识以及对侵略性青年进行干预措施。]拟议的研究将发生在坦普尔大学的临床心理学计划，该计划成功地记录了有影响力的NIMH资助研究与培训研究科学家。