Neural Mechanisms of Social Rejection elicited Aggression in Adolescence

社会拒绝的神经机制引发青春期的攻击行为

基本信息

批准号：
10313780
负责人：
Megan Quarmley
金额：
$ 3万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-11 至 2023-06-10
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10313780
关键词：
Active Learning Address Adolescence Adolescent Aggressive behavior Amygdaloid structure Anterior Anxiety Behavior Bipolar Disorder Brain Brain region Cause of Death Clinical Clinical Psychology Complex Country Data Dorsal Educational workshop Feedback Financial cost Foundations Functional Magnetic Resonance Imaging Funding Future Goals Grant Insula of Reil Link Measures Mediating Mental Depression Mental Health Mental disorders Mentorship Methodology Methods National Institute of Mental Health Neurobiology Neurocognitive Neuronal Plasticity Positioning Attribute Prefrontal Cortex Psychopathology Research Research Design Research Training Risk Schools Scientist Social Interaction Strategic Planning Symptoms Testing Time Training Universities Violence Work Youth anti social base behavioral study career cognitive control design experience implementation intervention intervention program method development neural network neural patterning neuroimaging neuromechanism novel peer peer influence prevent programs relating to nervous system response skills social success time use trait virtual

项目摘要

PROJECT SUMMARY/ABSTRACT Each year, violence in this country exacts staggering personal and financial costs. This burden is disproportionally born by adolescents, for whom violent behaviors linked to peer-based rejection are a leading cause of death. This may be related to the fact that peer relationships become highly salient in adolescence. Peer-based aggression is also a transdiagnostic symptom of several mental health disorders with high adolescent onset rates, and predicts risk for bipolar disorder, anxiety, and depression. Because adolescence is a sensitive period for neural plasticity, it is critical to identify neural mechanisms that bias youth towards perpetrating aggression before habitual antisocial tendencies are instantiated. Traditional intervention programs that target those at risk for perpetrating aggression have had only limited success. This may be because aggressive behavior is likely influenced by a complex cascade of neural responses that unfold across a social interaction. However, no study has examined these relations in adolescents, the group most impacted by peer-based aggression. Progress towards this goal has been hindered by the limited availability of ecologically-valid fMRI-based social interaction tasks that delineate temporal stages within a social interaction, such as anticipation and receipt of peer feedback, and contemplating aggression. The proposed work addresses these limitations by using a novel fMRI-based paradigm, the Virtual School and Aggression (VSA) task, to identify brain regions engaged at each temporal stage of a social interaction that predict aggressive behavior in adolescents (N=50; 11-15 years). I will also use time lapsed network interaction analyses, a novel form of functional connectivity analyses, to examine how the threat and cognitive control networks in the brain interact across distinct temporal stages as social rejection elicited aggression unfolds. Aims of this study are consistent with the NIMH strategic plan [(Objective 1): defining the mechanisms of complex behaviors, in this case, how social experiences and neural mechanisms influence peer-based aggressive behavior. The proposed study will determine both when during a social interaction regional brain function promotes aggressive behavior, and also how neural networks interact to promote social rejection elicited aggression. Such findings will provide novel treatment targets for aggressive behavior in youth. The proposed training plan, which consists of workshops, experiential learning, and mentorship, is designed to develop the applicant's expertise in the neurobiology of aggression, advanced neuroimaging methods, and the development and implementation of interventions for aggressive youth.] The proposed study will occur within Temple University's clinical psychology program, which has a successful track record of conducting impactful NIMH-funded research and training research scientists.

项目概要/摘要每年，这个国家的暴力都会造成惊人的个人和经济损失。这个负担是青少年出生的比例过高，对他们来说，与同伴排斥有关的暴力行为是主要的原因死亡原因。这可能与同伴关系在青春期变得非常重要有关。基于同伴的攻击也是多种精神健康障碍的一种跨诊断症状，其发病率较高。青少年发病率，并预测双相情感障碍、焦虑和抑郁的风险。因为青春期是神经可塑性的敏感期，识别导致青少年偏向的神经机制至关重要在习惯性反社会倾向出现之前实施攻击。传统干预针对那些有可能实施侵略的人的方案只取得了有限的成功。这可能是因为攻击行为很可能受到一系列复杂的神经反应的影响，这些反应在整个过程中展开社交互动。然而，还没有研究考察青少年（受影响最大的群体）中的这些关系。通过基于同伴的攻击。实现这一目标的进展因可用资源有限而受到阻碍生态有效的基于功能磁共振成像的社交互动任务，描绘社交互动中的时间阶段，例如预期和收到同伴反馈，以及考虑攻击行为。拟议的工作通过使用基于功能磁共振成像的新型范例虚拟学校和攻击（VSA）来解决这些限制任务，识别在社交互动的每个时间阶段参与预测攻击性的大脑区域青少年的行为（N=50；11-15 岁）。我还将使用延时网络交互分析，这是一部小说功能连接分析的形式，以检查大脑中的威胁和认知控制网络当社会排斥引发攻击行为时，它们会在不同的时间阶段进行互动。这项研究的目的是与 NIMH 战略计划一致[（目标 1）：定义复杂行为的机制，在此案例，社会经验和神经机制如何影响基于同伴的攻击行为。这拟议的研究将确定在社交互动期间区域大脑功能何时促进攻击性行为，以及神经网络如何相互作用以促进社会排斥引发攻击性。这些发现将为青少年攻击性行为提供新的治疗目标。拟议的培训计划，其中包括研讨会、体验式学习和指导，旨在培养申请人的能力攻击性神经生物学、先进神经影像学方法以及开发和研究方面的专业知识对好斗的青少年实施干预措施。]拟议的研究将在坦普尔大学的临床心理学项目，该项目在开展有影响力的 NIMH 资助方面拥有成功的记录研究和培训研究科学家。