Neural Effects of Negative Affect on Food Choices and Reward Processing In Individuals with Binge Eating Episodes

暴饮暴食个体的食物选择和奖励处理的负面影响的神经效应

基本信息

批准号：
10307096
负责人：
Guido KW Frank
金额：
$ 71.97万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-12-26 至 2024-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10307096
关键词：
Affect Affective Age Base of the Brain Behavior Behavioral Binge Eating Binge eating disorder Biological Brain Brain imaging Brain scan Bulimia Calories Categories Characteristics Cognition Cognitive Computer Models Control Groups Corpus striatum structure Depressed mood Diagnostic Disease Distress Dopamine Eating Eating Disorders Ecological momentary assessment Emotions Environment Exanthema Feeling Food Future Health Individual Insula of Reil Intervention Knowledge Learning Link Measures Morbidity - disease rate Motivation National Institute of Mental Health Neurobiology Neurosciences Neurotransmitters Obesity Persons Positive Valence Prefrontal Cortex Psychological reinforcement Quality of life Randomized Recurrence Regulation Reproducibility Research Research Domain Criteria Rewards Scanning Symptoms System Taste Perception Testing Ventral Striatum Vomiting Weight base behavioral study brain circuitry brain magnetic resonance imaging brain research cognitive control diagnostic criteria dopamine system healthy weight mind control mortality negative affect obese person psychopharmacologic relating to nervous system response reward processing sex therapy development

项目摘要

Project Summary Binge-eating is characterized by recurrent episodes of eating large amounts of foods, eating much more rapidly than normal and until feeling uncomfortably full, as well as feeling disgusted with oneself, depressed, or guilty after those episodes. Two eating disorders are characterized by binge-eating as central diagnostic criteria, bulimia nervosa (BN) and binge eating disorder (BED). Behavior studies have shown that negative affect and negative urgency (the tendency to act rashly when distressed) often drive binge-eating. A knowledge gap exists for 1) what neurobiological underpinnings are associated with negative affect that leads to loss of control and drives binge-eating, 2) whether neurotransmitter related brain circuits can be specifically linked to binge-eating, and 3) whether brain imaging can identify a brain based vulnerability for negative affect and excessive food intake in the natural environment. This application will study binge-eating across diagnostic categories, in individuals at normal weight with BN and obese individuals with BED, in contrast with normal weight or obese controls. We will apply the constructs cognitive control and positive valence system from NIMH's Research Domain Criteria (RDoC) project together with functional magnetic resonance brain imaging. In Aim 1. we will test whether negative affect alters brain reinforcement learning during a dopamine anchored taste reward paradigm. In Aim 2. we will study during a food choice paradigm the effects of negative affect on brain circuitry for cognitive control and food valuation. Aim 3. is to test whether brain activation predicts food intake or negative affect in a person's naturalistic environment, using ecological momentary assessment and meal observation. Binge-eating associated disorders are major health concerns with reduced quality of life and increased mortality rate, and the available treatments are limited. The neurobiology underlying binge-eating is not well understood and has not specifically been studied in a transdiagnostic approach using the NIMH's research domain criteria. This project will bridge affective-cognitive research knowledge with neurobiological brain research across eating disorders characterized by binge-eating as primary symptom. It will fill an important research and knowledge gap to develop intervention-directed research in the future.

项目摘要暴饮暴食的特征是经常食用大量食物，吃更多的食物比平常迅速，直到感到不舒服，并且对自己感到厌恶，沮丧，或在这些情节之后有罪。两种饮食失调的特征是暴饮暴食为中央诊断标准，神经性贪食症（BN）和暴饮暴食障碍（床）。行为研究表明负面情感和负面紧迫性（在遇到困扰时轻率行动的趋势）通常会引起暴饮暴食。一个存在知识差距1）哪些神经生物学基础与负责的负面影响相关为了失去控制和驱动狂饮，2）是否可以专门与暴饮暴食有关，以及3）大脑成像是否可以识别基于大脑的负面影响的脆弱性和自然环境中的食物摄入过多。该应用程序将研究狂欢诊断类别，与BN正常体重的个体与BN和肥胖个体有床的诊断类别，相反正常体重或肥胖对照。我们将应用构造的认知控制和正价系统来自NIMH的研究领域标准（RDOC）项目以及功能磁共振大脑成像。在AIM 1中。我们将测试负面影响多巴胺期间大脑增强学习的影响锚定的口味奖励范式。在AIM 2中。我们将在食物选择范式中学习负面的影响对脑电路的影响认知控制和食物估值。目标3是测试大脑是否激活使用生态瞬间，可以预测一个人的自然环境中的食物摄入或负面影响评估和进餐观察。暴饮暴食的相关疾病是主要的健康问题，减少了生活质量和增加的死亡率以及可用治疗的限制。神经生物学潜在的暴饮暴食尚不清楚，也没有在转诊中进行专门研究使用NIMH的研究领域标准的方法。该项目将桥接情感认知研究跨饮食失调的神经生物学大脑研究的知识，以暴饮暴食为特征主要症状。它将填补重要的研究和知识差距，以开发以干预为导向的未来的研究。