Alcohol Research Consortium in HIV: Biostatistics and Method Core

HIV 酒精研究联盟：生物统计学和方法核心

• 批准号: 10304373
• 负责人: Bryan Lau
• 金额: $ 22.69万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10304373
• 关键词: Abstinence; Accounting; Address; Affect; Age; Alcohol consumption; Alcohols; Area; Biological Markers; Biometry; Biostatistical Methods; Cardiovascular Diseases; Caring; Clinical; Cognition; Collaborations; Communities; Continuity of Patient Care; Data; Data Sources; Development; Disease remission; Effectiveness; Electronic Health Record; Ensure; Epidemic; Epidemiologic Methods; Epidemiology; Event; Fibrinogen; Goals; Grant; HIV; HIV Infections; Heterogeneity; Individual; Intervention; Leadership; Learning; Liver diseases; Machine Learning; Malignant Neoplasms; Measurement; Measures; Medical Records; Methodology; Methods; Neighborhoods; Outcome; Patient Outcomes Assessments; Patient Self-Report; Persons; Population; Process; Property; Publications; Recording of previous events; Recovery; Relapse; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Science; Site; Source; Statistical Methods; Treatment outcome; alcohol abuse therapy; alcohol intervention; alcohol measurement; alcohol relapse; alcohol research; alcohol risk; alcohol use disorder; barrier to care; base; cohort; comorbidity; comparison group; contextual factors; data management; design; evidence base; frailty; implementation science; improved; innovation; insight; novel; predictive modeling; social determinants; social health determinants; success; supervised learning; treatment as prevention; unsupervised learning; uptake

HIV Treatment as Prevention (TASP) is critical to Ending the HIV Epidemic (EHE). At-risk alcohol use and alcohol used disorder (AUD) are barriers to TASP through direct impacts on the HIV Care Continuum (HIV-CC). The impact of alcohol use on other comorbidities among persons with HIV (PWH) including liver disease, cardiovascular disease (CVD), malignancy, cognition, and frailty is increasingly relevant as persons age with HIV. The goals of ARCH are to implement evidence based alcohol interventions across the alcohol use spectrum (from no use, low risk, at-risk, AUD, recovery (low risk use or no use) or remission (no use) and relapse); to understand the contextual factors (i.e., social determinants of health [SDH] from the individual to community level) impact on alcohol use spectrum, the alcohol care continuum (Alc-CC), HIV –CC, and comorbidities; and to determine the optimal alcohol targets (abstinence, reduction in WHO risk score) and use different sources of alcohol measures to maximize information for determining alcohol status. The goal of the ARCH Biostatistics and Methods Core (ARCH-BMC) is to ensure that high quality contemporary research is carried out in terms of formulating research questions, study design, and analyses of the projects included within this P01. The ARCH- BMC will provide expertise and leadership in epidemiology and biostatistics in the quantitative support of the consortium. As has been done in prior years of ARCH, our group we will increase the depth to which research questions are pursued, resulting in increased quantity, quality, and effectiveness of the consortium research objectives, including the overall goals of the P01 (implementation science of alcohol interventions, impact of social determinants of health, and measures of alcohol). To accomplish this goal, we propose activities for both project support and methodological development. The specific aims of ARCH BMC are: 1) To provide wide- ranging, high-quality epidemiological and statistical support to ARCH, 2) To provide leadership in developing new statistical and epidemiological methods that address deficiencies in causal methods relevant to the novel research aims of the consortium, and 3) To integrate supplemental data sources and assessment of novel methodologies across the alcohol care continuum. ARCH-BMC adds value by contributing quantitative and epidemiological perspectives to the ARCH P01 scientific agenda and simultaneously operationalizing the science with appropriate study designs, data management, and analytical methodology. Successful research is accomplished by creating comprehensive partnerships that provide expertise throughout the entire research process, from the beginning with the conceptualization of the research question through all steps to publication. Innovation and improved research insights are obtained when collaborations integrate novel and improved methodology, uncovering further methodological challenges and motivating new areas for research. By supporting the research projects and working collaboratively with the transdisciplinary ARCH team, ARCH-BMC will increase the likelihood of success of ARCH in achieving its overall project goals.

HIV 治疗作为预防 (TASP) 对于结束 HIV 流行 (EHE) 至关重要。 使用障碍 (AUD) 通过对 HIV 护理连续体 (HIV-CC) 的直接影响而成为 TASP 的障碍。 饮酒对艾滋病毒感染者（PWH）其他合并症的影响，包括肝病、 随着人们年龄的增长，心血管疾病（CVD）、恶性肿瘤、认知和虚弱变得越来越重要 ARCH 的目标是在整个饮酒范围内实施基于证据的酒精干预措施。 （从不使用、低风险、有风险、AUD、恢复（低风险使用或不使用）或缓解（不使用）和复发）； 了解背景因素（即从个人到社区的健康社会决定因素 [SDH] 水平）对酒精使用谱、酒精护理连续体（Alc-CC）、HIV –CC 和合并症的影响； 确定酒精最佳目标（戒酒、降低世界卫生组织风险评分）并使用不同来源的酒精 ARCH 生物统计学的目标是最大限度地利用酒精测量信息来确定酒精状况。 和方法核心（ARCH-BMC）是为了确保在以下方面进行高质量的当代研究： 制定本 P01 中包含的研究问题、研究设计和项目分析。 BMC 将提供流行病学和生物统计学方面的专业知识和领导力，为 正如 ARCH 前几年所做的那样，我们小组将增加研究的深度。 提出问题，从而提高联盟研究的数量、质量和有效性 目标，包括 P01 的总体目标（酒精干预措施的实施科学、 健康的社会决定因素和酒精测量）为了实现这一目标，我们建议针对这两个目标开展活动。 ARCH BMC 的具体目标是： 1) 提供广泛的支持和方法开发。 为 ARCH 提供范围广泛、高质量的流行病学和统计支持，2) 领导制定 新的统计和流行病学方法，解决与小说相关的因果方法的缺陷 该联盟的研究目标，以及3）整合补充数据源和新颖的评估 ARCH-BMC 的方法论通过定量和贡献来增加价值。 ARCH P01 科学议程的流行病学视角并同时实施科学 适当的研究设计、数据管理和分析方法是成功的研究。 通过建立全面的合作伙伴关系来实现，在整个研究过程中提供专业知识 过程，从研究问题的概念化开始到发表的所有步骤。 当合作整合新颖和改进的内容时，就会获得创新和改进的研究见解 方法论，揭示进一步的方法论挑战并激发新的研究领域。 支持研究项目并与跨学科 ARCH 团队 ARCH-BMC 合作 将增加 ARCH 成功实现其总体项目目标的可能性。