COVID_Breastfeeding with COVID 19 disease: SARS-CoV-2 antibodies in breast milk and disease progression in the first six months of life

COVID_患有 COVID 19 疾病的母乳喂养：母乳中的 SARS-CoV-2 抗体和生命前六个月的疾病进展

• 批准号: 10303486
• 负责人: Sahira Askari Long
• 金额: $ 27.31万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-18 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10303486
• 关键词: 2019-nCoV; Academy; Address; Affect; American; Antibodies; Antibody Formation; Antibody-mediated protection; Biological Assay; Breast Diseases; Breast Feeding; CLIA certified; COVID-19; COVID-19 detection; Centers for Disease Control and Prevention (U.S.); Child; Clinical; Clinical Research; Communicable Diseases; Consumption; Coronavirus; Counseling; Data; Disease Progression; Enzyme-Linked Immunosorbent Assay; Epidemiologist; Face; Funding; Goals; Guidelines; Hand; Health Professional; Health care facility; Human Milk; Hygiene; Immunity; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Infant; Infection; Influenza; Knowledge; Laboratories; Lead; Life; Liquid substance; Maternal and Child Health; Maternal antibody; Medicine; Methodology; Middle East Respiratory Syndrome Coronavirus; Mothers; Newborn Infant; Nucleocapsid; Pediatrics; Proteins; Proteomics; Recommendation; Recurrence; Research; SARS-CoV-2 antibody; SARS-CoV-2 infection; SARS-CoV-2 positive; SARS-CoV-2 transmission; Saliva; Sample Size; Sampling; Scientist; Selection Bias; Serology test; Severe Acute Respiratory Syndrome; Symptoms; Testing; Universities; Viral; Virion; Virus; Virus Diseases; Visit; World Health Organization; antibody detection; base; cohort; coronavirus disease; epidemiology study; evidence based guidelines; follow-up; health organization; infection risk; neutralizing antibody; pediatrician; research study; response; saliva sample; sample collection; translational scientist

ABSTRACT It is unknown whether COVID-19 positive mothers transmit SARS-CoV-2 antibodies in their breast milk to protect their newborns or if breastfeeding can pose a risk of infection (either through consumption of virus or direct contact with the mother during feedings). Scientists hypothesize that (1) the breast milk of these mothers may have SARS-CoV-2 neutralizing antibodies which may confer protection; or (2) their breast milk can pose a risk of infection if the virus is shed in breast milk and consumed by the infant. Limited data are available thus far to support either hypothesis. As a result, SARS-CoV-2 related breastfeeding recommendations from the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC) and American Academy of Pediatrics (AAP) differ. However, previous research has shown that consumption of breast milk in early life confers immunity against several infectious diseases. Evidence-based recommendations for any guidelines require research and clinical studies. The goals of this research are to address this gap and determine if breast milk consumption can confer immunity. These goals will be met through the following specific aims. Specific Aim 1. Detect and quantify SARS-CoV-2 IgM/IgG/IgA antibodies that are present in breast milk and saliva from mother/infant dyads over 6 months. Specific Aim 2. Detect the presence of neutralizing antibodies in breast milk and saliva samples from mother/infant dyads. Specific Aim 3. Determine if and how consumption of breast milk from a COVID-19 positive mother affects SARS-CoV-2 infection, progression and possible recurrence in their infants.

抽象的 尚不清楚covid-19阳性母亲是否在其中传递SARS-COV-2抗体 母乳保护新生儿或母乳喂养会带来感染的风险（要么 通过食用病毒或在喂养过程中与母亲直接接触）。科学家 假设（1）这些母亲的母乳可能中和 可以提供保护的抗体；或（2）如果他们的母乳可能会构成感染的风险 病毒在母乳中脱落并被婴儿食用。到目前为止，数据有限 支持这两个假设。结果，SARS-COV-2相关的母乳喂养建议 来自世界卫生组织（WHO），疾病控制与预防中心（CDC） 美国儿科学会（AAP）也有所不同。但是，以前的研究表明 早期母乳的食用赋予了对几种传染病的免疫力。 任何指南的循证建议需要研究和临床研究。 这项研究的目标是解决这一差距，并确定母乳消耗是否可以 赋予免疫力。这些目标将通过以下特定目标实现。 特定目标1。检测并量化存在的SARS-COV-2 IgM/IgG/IgA抗体 在6个月内，母乳和唾液中的母乳和唾液二元。 特定目的2。检测母乳和唾液中中和抗体的存在 来自母/婴儿二元的样品。 特定目的3。确定与19的母乳的消费量是如何以及如何消耗。 积极的母亲影响SARS-COV-2感染，进展和可能复发 他们的婴儿。