Training Africans to Lead and Execute Neurological Trials & Studies (TALENTS)

培训非洲人领导和执行神经学试验

• 批准号: 10302951
• 负责人: BRUCE OVBIAGELE
• 金额: $ 24.64万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10302951
• 关键词: Africa; African; Clinical; Clinical Research; Event; Evidence based treatment; Exposure to; Face; Faculty; Foundations; Generations; Goals; Grant; Individual; Intervention; Knowledge; Lead; Leadership; Master' s Degree; Medicine; Mentors; Morbidity - disease rate; Motivation; Neurologic; Neurosciences Research; Nigeria; Pharmaceutical Preparations; Pharmacotherapy; Population; Program Effectiveness; Race; Research; Research Personnel; Risk Factors; Role; Safety; Scientist; Training; Training and Education; Universities; Ursidae Family; career; certificate program; effectiveness evaluation; efficacy testing; ethnic diversity; member; mortality; multidisciplinary; nervous system disorder; precision medicine; programs; skills; symposium; targeted treatment

PROJECT SUMMARY / ABSTRACT Africa faces a growing burden of non-communicable diseases as the fastest growing cause of morbidity and mortality, many of which are neurological disorders. Clinical studies are the foundation advancements in medicine allowing scientists to test the efficacy and safety of a drug, therapy or strategy; and clinical neuroscience research holds great promise to help mitigate the toll of neurological disease. However, the studies that lead to discovery of causal /risk factors & drugs/interventions rarely emanate from African populations, which bear a major brunt of neurological diseases. With the rise of precision medicine utilizing tailored interventions, lack of race-ethnic diversity in generating evidence-based treatments can be a challenge if people of African ancestry are to truly benefit from these targeted therapies. One way to bolster the limited pool of researchers in Africa conducting neurological research and trials is to expose select individuals to coordinated education, training, mentoring, & networking opportunities, thereby raising their odds of becoming successful clinical researchers, thus creating a cadre of people on the continent making academic contributions to the overall field of neurological diseases, including those conditions endemic to Africa. The goal of the Training Africans to Lead and Execute Neurological Trials & Studies (TALENTS) program, is to build sustainable neurological research capacity in Africa through partnerships between US and African organizations. Six scholars will be accepted into the program each year and exposed to educational, mentoring, & networking activities. TALENTS Specific Aims are: 1) To select & retain 24 promising multidisciplinary scholars from a cross-national pool) committed to careers in neurological research; 2) To increase scholars' scientific knowledge, professional skills, motivation, & credentials, in neurological research (Certificate Program, Master’s degree in Clinical Research, Think Tank Sessions, and Scientific Conference events); 3) To enhance mentoring benefits and networking opportunities for Scholars (congruent one-on-one mentoring approach and online networking activities); 4) By end of the grant period to create an independent Master’s degree in Neurological Research at the University of Ibadan in Nigeria, with several member of the faculty being recent TALENTS trainees; 5) To evaluate the effectiveness of the Program. We anticipate that TALENTS will establish a sustainable network of individuals with expertise in neurological research poised to assume leadership and academic faculty roles in Africa, and able to mentor successive generations of locally well-trained and successful neurological researchers in the region.

项目概要/摘要 非传染性疾病是非洲发病率增长最快的原因，非洲面临着日益沉重的负担 和死亡率，其中许多是神经系统疾病。 允许医学科学家测试药物、疗法或策略以及临床的功效和安全性； 神经科学研究有望帮助减轻神经系统疾病的损失。 导致发现因果/风险因素和药物/干预措施的很少来自非洲人群，这 随着利用定制干预措施的精准医疗的兴起，神经系统疾病首当其冲。 如果非洲人 血统是真正受益于这些靶向治疗的一种方法，可以增强有限的研究人员队伍。 非洲进行神经学研究和试验是为了让个人接受协调的教育， 培训、指导和交流机会，从而提高他们成为临床成功的几率 研究人员，从而在非洲大陆建立了一支为整个领域做出学术贡献的骨干队伍 神经系统疾病，包括非洲流行的疾病，培训非洲人领导力的目标。 和执行神经学试验和研究（TALENTS）计划，旨在建立可持续的神经学研究 通过美国和非洲组织之间的合作，六名学者将被接纳为非洲的能力。 每年参加该计划并参与教育、指导和网络活动。 是： 1) 从跨国人才库中选择并保留 24 名有前途的多学科学者）致力于职业生涯 2）提高学者的科学知识、专业技能、积极性； 神经学研究证书（证书课程、临床研究硕士学位、智库 3) 增强指导效益和交流机会 学者（一致的一对一指导方法和在线网络活动）；4) 资助结束时 在尼日利亚伊巴丹大学创建神经学研究独立硕士学位期间， 多名教员是最近的 TALENTS 培训生； 5) 评估项目的有效性； 我们预计 TALENTS 将建立一个由具有专业知识的个人组成的可持续网络。 神经学研究准备在非洲承担领导和学术教师角色，并能够指导 该地区历代训练有素且成功的神经学研究人员。