Examining the disparities in ovarian cancer survival among Asian Americans

检查亚裔美国人卵巢癌生存率的差异

• 批准号: 10302797
• 负责人: Robert Edward Bristow
• 金额: $ 7.18万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10302797
• 关键词: Address; Adherence; Asian Americans; Asian Indian; Asians; Automobile Driving; Behavioral; Biological; California; Cancer Patient; Caring; Cessation of life; Characteristics; Chinese People; Consensus; Data; Data Sources; Demographic Factors; Disease; Female; Filipino; Future; Geographic Locations; Grant; Guidelines; Heterogeneity; Histology; Home; Incidence; Japanese Population; Koreans; Light; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Malignant neoplasm of ovary; Masks; National Comprehensive Cancer Network; Operative Surgical Procedures; Patients; Pilot Projects; Population; Population Heterogeneity; Primary Neoplasm; Publishing; Race; Research; SEER Program; Socioeconomic Factors; United States; Woman; Work; cancer health disparity; cancer survival; cancer therapy; chemotherapy; data registry; health equity; improved; neoplasm registry; ovarian neoplasm; public health priorities; social; socioeconomics; surveillance data; survival disparity; treatment planning; tumor

Pilot Project 2: Project Summary Ovarian cancer is a highly fatal disease with a five-year relative survival of less than 50%. However, ovarian cancer survival is not the same for all women. Asian American ovarian cancer patients have the highest survival across all major racial groups, however the Asian American population is heterogeneous. Studies have shown that analyzing Asian Americans as a single group overlooks important ethnic-specific disparities, and this has been observed for ovarian cancer. Hence, this pilot project aims to better understand these disparities using data from the California Cancer Registry (CCR). The CCR is an ideal data source for this project given that it includes detailed demographic, socioeconomic, tumor, and treatment information by Asian subethnic group and covers the geographic region in the United States that is home to the largest number of Asian Americans. Our preliminary analyses of Asian American ovarian cancer patients using data in the CCR showed ethnic- specific percent differences for several survival-related characteristics. To clarify these differences, Aim 1 of this project will examine the association between Asian subethnic group and ovarian cancer tumor characteristics. Certain Asian subethnic groups may be more likely to present with ovarian cancers of a particular grade, stage, or histology, hence the ethnic-specific survival disparities may be attributed to the tumors themselves. Aim 2 of this project will examine whether receipt of National Comprehensive Cancer Network (NCCN) guideline adherent care and its association with ovarian cancer survival differ across Asian subethnic groups. NCCN guideline consensus statements reflect the most current and accepted standard for cancer treatment, hence the ethnic- specific survival disparities may be attributed to the treatment and care received. Certain Asian subethnic groups may be more likely to receive NCCN adherent care and receipt of that care may be differentially associated with survival. Given the fatality of ovarian cancer, understanding why some women die from ovarian cancer while others do not is a public health priority. Few ovarian cancer studies have focused on Asian Americans, hence this pilot project will not only shed light on an understudied segment of the population, but will do so in a way that recognizes the importance of the population's heterogeneity so ethnic-specific disparities are not overlooked. Understanding how ovarian tumors and treatment care may differ by Asian subethnic group will inform the future work that is needed to understand the underlying factors contributing to ovarian cancer disparities and survival overall.

试点项目2：项目摘要 卵巢癌是一种高度致命的疾病，相对生存率少于50％。但是，卵巢 对于所有女性，癌症的生存均不相同。亚裔美国卵巢癌患者的生存率最高 在所有主要种族群体中，亚裔美国人人口都是异质的。研究表明 分析亚裔美国人作为一个群体忽略了重要的民族特异性差异，这有 观察到卵巢癌。因此，这个试点项目旨在通过数据更好地理解这些差异 来自加利福尼亚癌症注册中心（CCR）。 CCR是该项目的理想数据源 亚洲亚族群的详细人口，社会经济，肿瘤和治疗信息，并涵盖 美国的地理区域是亚裔美国人数量最多的所在地。 我们使用CCR中数据对亚裔美国卵巢癌患者进行的初步分析表明，种族 几个与生存相关特征的特定百分比差异。为了澄清这些差异，目标1 项目将研究亚洲亚种群与卵巢癌肿瘤特征之间的关联。 某些亚洲亚种群体可能更有可能与特定等级的卵巢癌一起出现 或组织学，因此种族特异性的生存差异可能归因于肿瘤本身。目标2 该项目将检查是否收到国家综合癌症网络（NCCN）指南遵守指南 在亚洲亚种族中，护理及其与卵巢癌的生存相关。 NCCN指南 共识陈述反映了癌症治疗的最新和公认的标准，因此 特定的生存差异可能归因于接受的治疗和护理。某些亚洲亚种族群体 可能更有可能接受NCCN的遵守护理和收到该护理的接收可能与 生存。 鉴于卵巢癌的死亡，了解为什么有些女性死于卵巢癌，而另一些女性则是 不是公共卫生优先事项。很少有卵巢癌研究集中于亚裔美国人，因此该飞行员 项目不仅会阐明人口研究的一部分，而且会以某种方式这样做 认识到人口异质性的重要性，因此不忽略民族特定的差距。 了解亚洲亚族裔群体可能会有所不同 了解导致卵巢癌差异和生存的基本因素所需的工作 全面的。