Looking Back to Look Forward: Social Environment Across the Life Course, Epigenetics, and Birth Outcomes in Black Families

回顾过去并展望未来：生命历程中的社会环境、表观遗传学和黑人家庭的出生结果

• 批准号: 10295235
• 负责人: Jaime Catherine Slaughter-Acey
• 金额: $ 63.11万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10295235
• 关键词: Address; Affect; Aging; American; Archives; Back; Behavioral; Biological Aging; Biological Assay; Biological Markers; Birth; Birth Weight; Blood; Child; Cross-Sectional Studies; DNA Methylation; Data; Enrollment; Environment; Environmental Risk Factor; Epigenetic Process; Family; Fetal Growth; Generations; Genomics; Health; Individual; Length; Life Cycle Stages; Link; Measures; Mediating; Methylation; Modeling; Mothers; Neighborhoods; Newborn Infant; Outcome; Pathway interactions; Perinatal; Population; Pregnancy; Pregnant Women; Premature Birth; Race; Research; Research Personnel; Risk; Role; Sampling; Site; Social Environment; Socioeconomic Status; Source; Spottings; Stress; Stress and Coping; Theoretical model; Time; United States; Validation; Variant; Woman; Work; base; black women; black/white disparity; cohort; critical period; epigenome; epigenomics; health care service utilization; improved; indexing; infant outcome; insight; maternal stress; minority health; novel strategies; offspring; perinatal health; perinatal outcomes; prenatal; racial disparity; racism; social; social factors; sound; stressor; success; telomere

Improving the health outcomes for infants and children has been a national priority in the United States (US) for over a century. Despite great strides in improving perinatal health care and utilization among American women, key perinatal indicators have remained stagnant or worsened, the US continues to rank near the bottom, and racial disparities are persistent. While studies now have gone beyond behavioral and biomedical determinants of health and encompass the social environment, most research still remains focused on the time shortly before or during the pregnancy Improvements in perinatal health will require utilization of frameworks which integrate life-course and multiple-determinant models of health. Though the body of evidence linking the prenatal social environment, particularly maternal stress, and epigenome is growing, little work has yet explored the life course antecedents to the prenatal social environment and the impact on epigenetic methylation or telomere length. Based on our widely embraced framework for perinatal health that marries a multiple determinants model with a life course approach, we will investigate maternal social environmental influences on maternal methylation and telomere length. Change as well as critical periods will be assessed as the maternal social environment over the maternal life course may independently, cumulatively, and interactively impact the maternal epigenomic profile and its changes over the life course. Archived newborn blood spots, available for all pregnant women in this unique cohort of Black births in metro Detroit, will be assayed to determine the presence of epigenetic methylation and telomere length of mothers at their own birth; maternal measures at the index pregnancy will be derived from analogous blood spots collected in our study. Neighborhood level data will utilize both administrative and subjective measures of neighborhood. In addition to determining associations between the maternal social environment and her epigenomic features across her life course, we will endeavor to explore potential pathways linking the social environment and epigenome across the maternal life course with the perinatal outcomes of her offspring. Researchers have recently begun to consider social environmental factors and how they relate to epigenomic features as well as adverse perinatal outcomes. Yet those populations disproportionately affected by these outcomes are grossly underrepresented in genomic studies. Our sample of 1,000 births to Black women, with nearly half expected to women residing in Detroit, will provide a rich source of data on the maternal social environment across the life course and the epigenome. Our team possesses tremendous expertise in the study of perinatal outcomes as well as measures of social environmental factors often overlooked or not modeled in such a way as to provide understanding of mechanisms. Our study will substantially increase evidence about the importance of the maternal social context at multiple points in the life course on her epigenome and birth outcomes in offspring. The work holds promise for significantly increasing understanding about how social factors have influence across generations through epigenetic processes.

改善婴儿和儿童的健康状况一直是美国的国家优先事项 （美国）一个多世纪。尽管在改善美国的围产期医疗保健和利用方面取得了长足的进步 妇女，关键的围产期指标仍然停滞或恶化，美国继续排名在底部， 种族差异是持久的。尽管研究已经超越了行为和生物医学 健康的决定因素并涵盖了社会环境，大多数研究仍然集中在时间上 怀孕前或期间不久，围产期健康的改善将需要利用框架 这整合了生活过程和多重确定的健康模型。 尽管有联系的证据与产前社会环境，尤其是孕产妇的压力以及 表观基因组正在增长，几乎没有工作探索了产前社会环境的生命课程。 以及对表观遗传甲基化或端粒长度的影响。基于我们广泛接受的框架 围产期健康将多个决定因素模型与生活课程方法结合在一起，我们将调查 孕产妇社会环境对孕产妇甲基化和端粒长度的影响。改变 关键时期将被评估为孕产妇生活课程中的母亲社会环境 独立，累积和互动地影响孕产妇的表观基因质谱及其对 生活课程。存档的新生儿斑点，可用于所有独特的黑人出生队列中的所有孕妇 在底特律地铁中，将进行测定以确定表观遗传甲基化和端粒长度的存在 母亲自己出生；指数妊娠的孕产妇措施将来自类似的血液点 收集在我们的研究中。邻里级别的数据将同时采用行政和主观度量 邻里。除了确定孕产妇社会环境与她之间的关联 她的人生课程中的表观基因组特征，我们将努力探索与社会联系的潜在途径 在孕产妇生活过程中的环境和表观基因组，其后代的围产期结果。 研究人员最近开始考虑社会环境因素及其与他们之间的关系 表观基因组特征以及不良围产期结果。然而那些人群受到了不成比例的影响 通过这些结果在基因组研究中的人数严重不足。我们的1,000次分娩样本 妇女，预计将有近一半的妇女居住在底特律，将为母亲提供丰富的数据来源 整个生命过程和表观基因组的社会环境。我们的团队在 研究围产期结果以及经常被忽视或未建模的社会环境因素的度量 以一种提供对机制的理解的方式。我们的研究将大大增加有关的证据 孕产妇社会环境在人生过程中多个点上的重要性对她的表观基因组和出生的重要性 后代的结果。这项工作有望大大提高人们对社会因素的理解 通过表观遗传过程在各个世代产生影响。