Language processing in context in individuals with Alzheimer’s disease

阿尔茨海默病患者的语言处理

基本信息

批准号：
10288156
负责人：
Sarah Brown-Schmidt
金额：
$ 42.18万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-12-11 至 2024-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10288156
关键词：
Administrative Supplement Adult Affect Alzheimer&apos s Disease Amnesia Aphasia Basic Science COVID-19 pandemic Caring Chronic Clinic Clinical Clinical Management Clinical Research Cognition Cognitive Communication Communication impairment Comprehension Cues Diffuse Pattern Family member Foundations Future Heart Hippocampus (Brain)Impairment Individual Intervention Investigation Knowledge Language Language Disorders Life Linguistics Measures Medial Memory Memory impairment Methods Nature Outcome Participant Pathology Patients Performance Physical environment Production Prognosis Quality of life Rehabilitation therapy Research Secondary to Social Interaction Stretching Structure Temporal Lobe Time Traumatic Brain Injury Work behavior measurement flexibility improved language processing novel novel strategies phrases programs relating to nervous system social social communication social group stem theories visual tracking

Administrative Supplement Adult Affect Alzheimer&apos s Disease Amnesia Aphasia Basic Science COVID-19 pandemic Caring Chronic Clinic Clinical Clinical Management Clinical Research Cognition Cognitive Communication Communication impairment Comprehension Cues Diffuse Pattern Family member Foundations Future Heart Hippocampus (Brain)Impairment Individual Intervention Investigation Knowledge Language Language Disorders Life Linguistics Measures Medial Memory Memory impairment Methods Nature Outcome Participant Pathology Patients Performance Physical environment Production Prognosis Quality of life Rehabilitation therapy Research Secondary to Social Interaction Stretching Structure Temporal Lobe Time Traumatic Brain Injury Work behavior measurement flexibility improved language processing novel novel strategies phrases programs relating to nervous system social social communication social group stem theories visual tracking

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项目摘要

ABSTRACT A significant challenge in the empirical study and clinical management of cognitive-communication impairment, a hallmark deficit in individuals with traumatic brain injury (TBI) and Alzheimer's disease (AD), is that commonly used methods to detect these deficits in clinical and research settings lack the required sensitivity and have focused on a limited subset of discourse tasks that do not reliably predict communication outcomes. At the heart of our proposal is the idea that current theories of cognitive-communication are too narrow and the methods used to detect deficits are too limiting. In contrast to current conceptualizations which state that cognitive-communication deficits affect discourse and conversation (leaving basic sentence level processing intact), we propose that cognitive-communication impairment is a deficit in the flexible use and processing of language that manifests across the varied and dynamic contexts of everyday language use, whether processing a single sentence or participating in a multiparty conversation. From this perspective, there is a striking disconnect in the field between clinical observations of impairments in using language in context and the widespread use of decontextualized tasks and measures to capture these deficits in the lab and clinic (e.g., monologue discourse task). Using ecologically valid language tasks and methods sensitive enough to detect even subtle, though meaningful, disruptions in language, this administrative supplement extends our work on language processing in TBI to individuals with Alzheimer's disease. The proposed program of research represents a novel direction in the study of cognitive communication impairment in individuals with AD with substantial basic science and clinical translational significance. The proposal is organized around two AIMS: (1) To investigate language processing in context in AD; (2) To investigate language use in group settings in AD. This proposal is unique in the field and uniquely promising for understanding the nature of deficits in contextual language processing and, ultimately, improving rehabilitation intervention outcomes.

抽象的认知通信障碍的实证研究和临床管理中的一个重大挑战，脑损伤（TBI）和阿尔茨海默氏病（AD）患者的标志性赤字是在临床和研究环境中检测这些缺陷的常用方法缺乏所需的灵敏度并专注于没有可靠地预测沟通结果的有限的话语任务。我们提出的核心是当前认知通信理论太狭窄，用于检测缺陷的方法太限制了。与当前指出的概念相反认知通信缺陷会影响话语和对话（留下基本句子级处理完整），我们建议认知通信障碍是灵活使用和处理的赤字在日常语言使用的多样化和动态环境中表现出的语言，是否处理单个句子或参加多方对话。从这个角度来看，有一个在上下文中使用语言的临床障碍观察之间的临床观察和在实验室和诊所中捕获这些缺陷的典型化任务和措施的广泛使用（例如，独白话语任务）。使用具有生态有效的语言任务和方法对检测到足够敏感的方法这种行政补充甚至是微妙的，虽然有意义的，但在语言上的破坏也扩展了我们的工作 TBI对阿尔茨海默氏病的患者进行语言处理。拟议的研究计划在研究AD患者认知沟通障碍的研究中，代表了一个新的方向实质性的基础科学和临床翻译意义。该提案围绕两个目标组织：（1）在AD中的上下文中调查语言处理；（2）研究小组中的语言使用广告中的设置。该提议在该领域是独一无二的，并且是理解本质的独特有希望的上下文语言处理中的缺陷，并最终改善康复干预结果。