Language processing and the hippocampal declarative memory system

语言处理和海马陈述性记忆系统

• 批准号: 8620643
• 负责人: Sarah Brown-Schmidt
• 金额: $ 37.77万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8620643
• 关键词: Alzheimer' s Disease; Amnesia; Aphasia; Area; Behavioral; Binding; Biological Neural Networks; Brain; Cereals; Characteristics; Clinical; Clinical Services; Cognitive; Complex; Comprehension; Development; Diagnosis; Early Diagnosis; Early identification; Eye; Generations; Hippocampus (Brain); Impairment; Individual; Language; Language Disorders; Linguistics; Link; Measures; Memory; Memory impairment; Mental disorders; Neurologic; Non-aphasic; Patients; Performance; Play; Positioning Attribute; Prefrontal Cortex; Process; Production; Psycholinguistics; Research; Retrieval; Role; Schizophrenia; Short-Term Memory; Signal Transduction; Source; Speech; Speech Perception; Stimulus; Stroke; System; Testing; Time; Traumatic Brain Injury; Validation; Work; behavior measurement; cognitive neuroscience; effective intervention; executive function; flexibility; improved; information processing; insight; language processing; long term memory; meetings; mental representation; nervous system disorder; neuropsychological; novel; operation; phrases; programs; theories; tool

DESCRIPTION (provided by applicant): This research program explores the novel hypothesis that many of the processes by which we produce and understand language also place high demands on and receive contributions from the hippocampal declarative memory system. This system is uniquely positioned to access and integrate discourse, contextual and experiential information that the language processing system relies on to resolve ambiguity and create meaning. Recent provocative work extends the traditional view of declarative memory as contributing exclusively to long-term memory, to include a critical role in the generation and use of on-line representations, created during ongoing and online information processing to support behavioral performance in the moment. The proposed studies build upon a set of exciting preliminary findings revealing language deficits at low levels of language processing (i.e., within a single noun phrase), and in the absence of any explicit demands on memory (e.g., no delays; when all the stimuli remain in view) in patients with severe and selective declarative memory impairment. Our studies are built around investigating three key areas of language processing where proposals of the memory determinants are central, but untested: Aim 1: To investigate the demands of interactive dialogue on declarative memory; Aim 2: To investigate the demands of referential processing on declarative memory; Aim 3: To investigate the demands of accommodation of talker variability on declarative memory. Our experimental approach capitalizes on a compelling opportunity to combine the study of patients with hippocampal amnesia with eye tracking and behavioral measures to examine the necessity of a form of memory in meeting the demands of language. We will therefore be uniquely able to determine the contributions of hippocampus and declarative memory to language processing and use across multiple levels of language production and comprehension providing crucial tests of hypothesized roles for memory in language use. Language disruptions are common in many neurological and psychiatric conditions where impairments in declarative memory are also prominent, including stroke, traumatic brain injury, Alzheimer's disease, and schizophrenia. Thus, our efforts to characterize the observed language deficits and link them to underlying memory mechanisms are necessary for understanding the broader neural network and cognitive processes that support language use and for developing more sensitive assessments and effective interventions. This application, and the findings generated, offers unparalleled insights and advancements for theories of language processing, clinical service delivery to individuals with concomitant disorders of language and memory, and understanding the organization and operation of language in the brain.

描述（由申请人提供）：该研究项目探索了一个新的假设，即我们产生和理解语言的许多过程也对海马陈述性记忆系统提出了很高的要求并接受其贡献。该系统具有独特的定位，可以访问和整合语言处理系统赖以解决歧义和创造意义的话语、上下文和经验信息。最近的挑衅性工作扩展了陈述性记忆仅对长期记忆做出贡献的传统观点，包括在在线表征的生成和使用中发挥关键作用，这些表征是在持续的在线信息处理过程中创建的，以支持当前的行为表现。拟议的研究建立在一系列令人兴奋的初步发现之上，这些发现揭示了低水平语言处理（即在 单个名词短语），并且对患有严重和选择性陈述性记忆障碍的患者没有任何明确的记忆要求（例如，没有延迟；当所有刺激都在视野中时）。我们的研究围绕调查语言处理的三个关键领域而展开，其中记忆决定因素的建议是核心，但未经测试： 目标 1：调查交互式对话对陈述性记忆的需求；目标2：调查参照处理对陈述性记忆的需求；目标 3：调查调节说话者变异性对陈述性记忆的需求。我们的实验方法利用了一个令人信服的机会，将海马失忆症患者的研究与眼球追踪和行为测量结合起来，以检查某种形式的记忆在满足语言需求方面的必要性。因此，我们将能够独特地确定海马体和陈述性记忆对多个语言产生和理解水平的语言处理和使用的贡献，为记忆在语言使用中的假设作用提供关键测试。语言障碍在许多神经和精神疾病中很常见，其中陈述性记忆损伤也很突出，包括中风、创伤性脑损伤、阿尔茨海默病和精神分裂症。因此，我们努力描述观察到的语言缺陷并将其与潜在的记忆机制联系起来，对于理解支持语言使用的更广泛的神经网络和认知过程以及开发更敏感的评估和有效的干预措施是必要的。该应用程序以及生成的研究结果提供了无与伦比的见解 语言处理理论的进步，为患有语言和记忆障碍的个体提供临床服务，以及理解大脑中语言的组织和运作。