MRI-guided biopsy of pelvic bone marrow edema lesions in axial spondyloarthritis

MRI引导下中轴型脊柱关节炎盆腔骨髓水肿病变活检

基本信息

批准号：
10288006
负责人：
Joerg Ermann
金额：
$ 22.29万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2023-07-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10288006
关键词：
Ankylosis Bone Marrow Bone marrow biopsy CD8-Positive T-Lymphocytes Cells Characteristics Core Biopsy Development Disease Edema Exploratory/Developmental Grant Flow Cytometry Future Goals Histopathology Hospitals Image Guided Biopsy Immune Immunologist Individual Inflammatory Inflammatory Infiltrate Institutional Review Boards Interleukin-17 Intervention Investigation Lesion Location Magnetic Resonance Imaging Marrow Masks Molecular Analysis Multimodal Imaging Nature Pathogenesis Patients Pelvis Peripheral Blood Mononuclear Cell Pilot Projects Play Positioning Attribute Process Protocols documentation Radiology Specialty Research Research Infrastructure Rheumatoid Arthritis Risk Role Sacroiliac joint structure Sclerosis Signal Transduction Specimen Spondylarthritis Structure Synovitis TNF gene Tissues Training Woman base bone enthesitis experience experimental study hip bone histological stains image guided inhibitor/antagonist microCT osteoimmunology prevent radiologist research facility rheumatologist single-cell RNA sequencing spine bone structure subchondral bone success γδ T cells

项目摘要

Project Summary Subchondral bone marrow edema lesions are a characteristic magnetic resonance imaging (MRI) finding of sacroiliitis in patients with axial spondyloarthritis (SpA). The histopathological equivalent of bone marrow edema in axial SpA is unknown. Based on studies in rheumatoid arthritis, we hypothesize that the bone marrow edema lesions in axial SpA represent inflammatory infiltrates. In this pilot study, patients with axial SpA and healthy controls will undergo MRI-guided bone marrow biopsy to determine the histopathology of bone marrow edema lesions detected on MRI and identify major immune cell subsets present in these lesions. The results from these experiments will determine feasibility and guide larger scale investigations into the pathogenesis of axial SpA in the future. Understanding SpA pathogenesis at the level of the diseased tissue is a key requirement for the development of strategies to cure or prevent this disease.

项目概要软骨下骨髓水肿病变是磁共振成像 (MRI) 的特征性发现中轴型脊柱关节炎 (SpA) 患者的骶髂关节炎。组织病理学相当于骨髓中轴型 SpA 水肿尚不清楚。根据类风湿性关节炎的研究，我们假设骨中轴 SpA 的骨髓水肿病变代表炎症浸润。在这项试点研究中，患有中轴病的患者 SpA 和健康对照者将接受 MRI 引导的骨髓活检以确定组织病理学 MRI 检测到骨髓水肿病变并识别这些病变中存在的主要免疫细胞亚群病变。这些实验的结果将确定可行性并指导更大规模的研究未来将深入探讨中轴型 SpA 的发病机制。了解 SpA 的发病机制患病组织是制定治疗或预防这种疾病的策略的关键要求。