Age-related hearing deficits in noise-exposed mouse models of Alzheimer's Disease

暴露于噪音的阿尔茨海默病小鼠模型中与年龄相关的听力缺陷

基本信息

批准号：
10284502
负责人：
MICHEAL L DENT
金额：
$ 28.7万
依托单位：
STATE UNIVERSITY OF NEW YORK AT BUFFALO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10284502
关键词：
APP-PS1 Acoustic Trauma Acoustics Address Affect Age Age-Months Aging Alzheimer&apos s Disease Alzheimer&apos s disease model Alzheimer&apos s disease risk Anatomy Auditory Auditory Brainstem Responses Auditory area Awareness Behavioral CBA/CaJ Mouse Chronic Communication Controlled Environment Detection Environment Environmental Risk Factor Exposure to Female Genetic Predisposition to Disease Genetic Risk Goals Health Hearing Hearing problem Human Knowledge Laboratory mice Learning Link Longevity Loudness Measures Methodology Modeling Mus Nature Noise Nose Operant Conditioning Pathology Patients Physiological Play Positive Reinforcements Predisposition Presbycusis Procedures Process Publishing Reporting Research Research Proposals Role Sex Differences Speech Study models Sum Techniques Training Transgenic Mice Wild Type Mouse age difference age effect awake behavior measurement early onset experience experimental study genetic variant hearing impairment male mouse model mutant parent grant parent project sex speech in noise

项目摘要

Summary It is well known that Alzheimer's disease (AD) and hearing loss often occur together. What is unknown, however, is the relationship between noise exposures and patients with AD. Our goal with this supplement is to examine the link between noise exposure, age, listening environment (noise or quiet), and sex in transgenic mouse models of AD compared to wild-type mice. In our one Specific Aim, we will behaviorally measure auditory acuity before and after noise exposures in the above groups of mice and the two listening environments to determine if young AD mutants are more susceptible to noise exposure than young wild-type mice, and to examine the differences of the susceptibility to noise in quiet and noise environments. In our parent grant, we have been measuring the effects of noise on hearing in young and old, male and female mice, and have found that old mice suffer greater hearing loss post-noise exposure than young mice when listening in quiet environments, but not in noisy environments. This supplement will utilize the same techniques in two mouse models of AD to determine if young AD mice act like old wild-type mice in terms of susceptibility to hearing loss following acoustic trauma. Although these mouse models are commonly used to study the anatomical correlates of AD, we are only beginning to comprehend the functional implications of AD on hearing, especially hearing in noise, and these experiments will help us better understand how aging, sex, and noise all play a role in the communication problems faced by patients with AD.

概括众所周知，阿尔茨海默氏病（AD）和听力损失经常在一起。什么是未知的，但是，噪声暴露与AD患者之间的关系。我们用这种补充的目标是检查噪声暴露，年龄，听力环境（噪音或安静）与转基因性别之间的联系与野生型小鼠相比，AD的小鼠模型。在我们的一个特定目标中，我们将在行为上衡量在上述小鼠组中噪声曝光之前和之后的听觉敏锐度，两者聆听确定年轻广告突变体是否比年轻野生型更容易受到噪声的影响小鼠，并检查在安静和噪音环境中噪声的敏感性的差异。在我们的父母赠款，我们一直在衡量噪音对年龄，男女的听力的影响老鼠，发现老鼠在噪声后暴露后与年轻小鼠相比，老鼠的听力损失更大。在安静的环境中聆听，但不在嘈杂的环境中。该补充剂将使用相同的两种鼠标模型中的技术，以确定年轻的AD小鼠是否像旧野生型小鼠一样起作用声学创伤后听力损失的敏感性。尽管这些鼠标模型通常用于研究AD的解剖学相关性，我们才开始理解AD的功能含义听到噪音，尤其是听力，这些实验将有助于我们更好地了解衰老，性别，性和噪音都在AD患者面临的沟通问题中发挥作用。