Feasibility of the Mindfulness-Based Stress Reduction Intervention for BlackWomen Living with HIV

针对感染艾滋病毒的黑人女性进行基于正念的减压干预的可行性

基本信息

批准号：
10285078
负责人：
Crystal LaShonda Chapman Lambert
金额：
$ 13.62万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-15 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10285078
关键词：
AIDS dementia Address Adherence African American Age Aging Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Attention Attenuated Award Awareness Biological Markers Breast Cancer survivor CD4 Lymphocyte Count Chronic Disease Clinical Cognition Cognitive Data Dementia Educational Curriculum Enrollment Epidemic Female Female Breast Carcinoma Focus Groups Future Gender General Population Goals HIV Health Health behavior outcomes Home Impaired cognition Informal Social Control Interpersonal Violence Intervention Life Expectancy Literature Manuals Medical Mental Depression Outcome Parents Participant Population Population Heterogeneity Post-Traumatic Stress Disorders Prevalence Process Protocols documentation Public Health Quality of life Randomized Recommendation Reporting Research Risk Risk Factors Severities Socioeconomic Status Stress Stressful Event Surveys Survivors Target Populations Testing Therapeutic Time Training Treatment Failure Treatment outcome Viral Viral Load result Visit Woman acceptability and feasibility antiretroviral therapy arm base career development cognitive function cohort comparison intervention coping daily functioning efficacy evaluation efficacy testing experience follow-up gender disparity improved improved outcome male medication compliance mild cognitive impairment mindfulness intervention mindfulness-based stress reduction mortality patient population physical symptom psychologic psychological distress psychological symptom psychosocial racial disparity recruit research and development satisfaction stress management stress reduction symptom management systematic review therapy adherence treatment adherence usual care arm

项目摘要

Project Summary/Abstract People living with HIV (PLWH) are seven times more likely to have mild cognitive impairment (MCI) than people without HIV. Women living with HIV (WLWH), and more specifically African American (AA) WLWH, have evidenced poorer cognitive function when compared to their male counterparts living with HIV and women without HIV. Few studies have targeted this population in non-pharmacological strategies to mitigate cognitive impairment. The current proposed study will assess the feasibility and acceptability of mindfulness-based stress reduction (MBSR) in AA WLWH with MCI. MBSR has the potential to reduce stress through self-regulation of attention and awareness to stressful events. MBSR has demonstrated efficacy in improving or stabilizing cognition, improving stress management, psychological distress, physical and psychological symptoms, quality of life, and coping in the general population, as well as ART adherence in PLWH. Yet, the studies have been conducted in predominately white and male patient populations. Thus, the research proposed here will begin to address these gaps by piloting the MBSR intervention for AA WLWH with MCI. This will be an important first step in developing and implementing MBSR protocols in AA WLWH with MCI. In our Supplement Aim we will conduct a two-arm randomized pilot test of the adapted intervention compared to a usual care control group among 30 AA WLWH (15/arm) to assess the feasibility and acceptability of the MBSR among WLWH with MCI. Feasibility will be assessed by our ability to (1) recruit, randomize, and retain participants and (2) deliver the intervention per the manual, as well as (3) participants adherence to home practices and assignments. Acceptability will be assessed via qualitative data (focus group input regarding participants’ satisfaction with the intervention and intent to continue using the practices), as well quantitative data (satisfaction survey). The ultimate goal of this research is to: 1) reduce racial and gender disparities in cognitive impairment and dementia prevalence, 2) inform next steps for efficacy testing and implementation of a group-based non-pharmacologic interventions targeting cognitive outcomes in diverse populations, and 3) impact clinical and public health recommendations for maintaining cognitive health in aging populations.

项目概要/摘要艾滋病毒感染者 (PLWH) 患有轻度认知障碍 (MCI) 的可能性是未感染艾滋病毒的人的七倍。相比之下，感染艾滋病毒的女性 (WLWH)，特别是非洲裔美国人 (AA) WLWH，其认知功能较差。很少有研究针对这一人群采取非药物策略来减轻认知障碍，目前拟议的研究将评估基于正念的减压（MBSR）在 AA WLWH 中的可行性和可接受性。和MCI。MBSR 具有通过对压力事件的注意力和意识进行自我调节来减轻压力的潜力，MBSR 已证明在改善或稳定认知、改善压力管理、心理困扰、身体和心理症状、生活质量和应对方面有效。然而，这些研究主要是在白人和男性患者群体中进行的，因此，本文提出的研究将通过对 AA WLWH 进行 MBSR 干预试点来解决这些差距。 MCI。这将是在 AA WLWH 和 MCI 中制定和实施 MBSR 方案的重要第一步。在我们的补充目标中，我们将在 30 名 AA WLWH 中与常规护理对照组进行双臂随机试点测试。（15/组）评估 MCI 的 WLWH 中 MBSR 的可行性和可接受性将根据我们 (1) 招募、随机化和留住参与者以及 (2) 交付参与者的能力来评估可行性。根据手册进行干预，以及 (3) 参与者对家庭实践和作业的遵守情况将通过定性数据（焦点小组输入参与者对干预的满意度和继续使用实践的意图）以及定量数据进行评估。（满意度调查）。这项研究的最终目标是：1）减少认知障碍和痴呆症患病率的种族和性别差异，2）为功效测试和实施针对认知结果的基于群体的非药物干预措施提供信息。在不同的人群中，以及3) 影响维持老年人认知健康的临床和公共卫生建议。