Biomedical Informatics, Bioinformatics, and Cyberinfrastructure Enhancement Core

生物医学信息学、生物信息学和网络基础设施增强核心

• 批准号: 10281662
• 负责人: CHITTIBABU GUDA
• 金额: $ 35.35万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10281662
• 关键词: Adopted; Agreement; Area; Bioinformatics; Center for Translational Science Activities; Centers of Research Excellence; Child Health; Clinical; Clinical Data; Clinical Informatics; Clinical Research; Collaborations; Collective Bargaining; Community Health; Core Facility; Data; Data Analyses; Data Collection; Data Correlations; Decision Support Systems; Development; Diagnostic; Disease; Dissemination and Implementation; Educational Curriculum; Educational process of instructing; Educational workshop; Electronic Health Record; Environment; Feasibility Studies; Funding; Genetic; Genomics; Goals; Great Plains; Health; Healthcare; Home; Hospitals; Human Resources; Individual; Informatics; Infrastructure; Institution; Knowledge; Link; Machine Learning; Mentors; Mission; Molecular; Monitor; Nebraska; Outcome; Outcomes Research; Physicians; Population; Precision Health; Protocols documentation; Public Health Informatics; Registries; Research; Research Activity; Research Personnel; Resource Informatics; Resource Sharing; Resources; Rural Population; Sampling; Science; Services; Technical Expertise; Technology; Training; Training Activity; Training Programs; Translational Research; Underserved Population; base; biobank; biomedical informatics; certificate program; clinical infrastructure; clinical practice; clinically relevant; cohort; coronavirus disease; cyber infrastructure; data access; data integration; data resource; data sharing; density; design; genomic data; health data; healthcare community; heterogenous data; informatics infrastructure; informatics tool; innovation; interoperability; liquid biopsy; member; mobile application; next generation sequencing; novel diagnostics; operation; personalized health care; precision medicine; prognostic; programs; resource guides; success; support tools; telehealth; tool; tool development; wearable device; web portal

Biomedical Informatics, Bioinformatics, and Cyberinfrastructure Enhancement Project Summary The Biomedical Informatics, Bioinformatics, and Cyberinfrastructure Enhancement (BIBCE) Core offers a robust and agile biomedical informatics infrastructure for the Great Plains (GP) IDeA-CTR members with cutting-edge support tools, expertise and training across bio-, clinical-, and public health informatics realms. Extensive reliance on genetic and molecular data in clinical practice has become a game-changer in health care practice, especially, in the emerging field of precision medicine. Hence, clinical and translational research (CTR) needs a range of supports from data collection and analysis to data integration and correlation to make clinically relevant inferences effectively. However, it is extremely challenging for individual institutions to locally develop and maintain sophisticated infrastructure and technical expertise in this rapidly changing field. The primary objective of the BIBCE Core is to develop such an environment, expertise, tools, and services and make them accessible across all institutions of the GP IDeA-CTR network. Collecting and connecting data from the molecular level to population level, the BIBCE Core will provide access to a robust suite of tools for regional CTR endeavors while building the overall CTR capacity of the GP IDeA-CTR network. While Nebraska has an extensive telehealth network that links all public educational facilities and hospitals, informatics tools and expert support are essential to generate multi-institutional collaborations in CTR and having a centrally supported core will be pivotal to accomplish the mission of GP IDeA-CTR. The BIBCE Core will support this mission with four specific aims: 1) Augment CTR capacity by leveraging existing infrastructure, networking, and creative collaborations among GP IDeA-CTR, institutional, and other IDeA-funded projects; 2) Integrate and streamline access to genomics-based and community health data, biobanks & registries, electronic health records, and decision support systems across the network to promote translational precision health research; 3) Connect the clinical informatics resources with CTSA’s National Center for Data to Health (CD2H) and other CTR centers to facilitate easy access and stimulate feasibility studies, outcomes research, and CTR; and 4) Support data sharing, knowledge and resource sharing, and training using cyberinfrastructure to reach out to the rural and underserved populations in the GP IDeA-CTR network. The BIBCE Core will have a profound impact on the success of GP IDeA-CTR through augmenting the overall research capacity in the realms of clinical, translational, and precision health; bolstering collaborations through team science within as well as across the IDeA networks; streamlining diverse informatics resources; aligning the regional CTR with national efforts for interoperability; sharing knowledge with new courses and training activities; and finally, developing telehealth tools to reach out to the rural and underserved populations.

生物医学信息学，生物信息学和网络基础设施增强项目摘要 生物医学信息学，生物信息学和网络基础设施增强（BIBCE）核心提供 大平原（GP）Idea-CTR成员的强大而敏捷的生物医学信息基础设施 跨生物，临床和公共卫生信息领域的尖端支持工具，专业知识和培训。 在临床实践中，人们对遗传和分子数据的广泛依赖已成为改变健康的游戏 护理实践，尤其是在精密医学的新兴领域。因此，临床和翻译研究 （CTR）需要一系列从数据收集和分析到数据集成和相关性的支持，以使 有效的临床相关推论。但是，对于各个机构来说，在本地面临极大的挑战 在这个快速变化的领域中，开发和维持复杂的基础架构和技术专长。这 Bibce核心的主要目标是开发这样的环境，专业知识，工具和服务以及 使它们可以在GP Idea-CTR网络的所有机构中访问。收集和连接数据 分子水平达到人口水平，Bibce核心将为适用的工具提供访问 在建立GP Idea-CTR网络的总体CTR能力的同时，区域CTR努力。而内布拉斯加州 具有广泛的远程医疗网络，该网络将所有公共教育设施和医院，信息工具联系起来 专家支持对于在CTR中建立多机构合作至关重要 支持的核心将是完成GP Idea-CTR的任务的关键。 Bibce核心将支持这一点 具有四个具体目标的任务：1）通过利用现有基础设施，网络，增强CTR的能力 以及GP Idea-CTR，机构和其他Idea资助的项目之间的创造性合作； 2）集成 并简化访问基于基因组学和社区健康数据，生物库和注册表，电子健康的访问权限 记录和整个网络的决策支持系统，以促进翻译精度健康研究； 3）将临床信息资源与CTSA国家数据中心联系起来（CD2H）和其他 CTR中心促进易于访问和刺激可行性研究，结果研究和CTR；和4） 支持数据共享，知识和资源共享以及使用Cyber​​inFrstructure的培训 GP Idea-CTR网络中的粗糙和服务不足的人群。 Bibce核心将有一个深刻的 通过增强领域的总体研究能力来影响GP Idea-CTR的成功 临床，翻译和精度健康；通过团队科学以及 整个想法网络；简化潜水员信息资源；将区域CTR与国家保持一致 互操作性的努力；与新课程和培训活动分享知识；最后，发展 远程医疗工具可以接触到不受欢迎的人群。