A NONLINEAR MEMBRANE BASED ANALYSIS FOR ESTIMATING THE RUPTURE POTENTIAL OF ABDOMINAL AORTIC ANEURYSMS

基于非线性膜的分析估计腹主动脉瘤的破裂可能性

• 批准号: 10280976
• 负责人: ENDER A FINOL
• 金额: $ 53.28万
• 依托单位: UNIVERSITY OF TEXAS SAN ANTONIO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10280976
• 关键词: Abdomen; Abdominal Aortic Aneurysm; Aneurysm; Award; Biomechanics; Blood Vessels; Caliber; Clinic; Clinical; Clinical Management; Clinical Research; Computer software; Consent; Detection; Development; Disease; Disease Management; Event; Exhibits; Finite Element Analysis; Future; Geometry; Goals; Growth; Guidelines; Human Subject Research; Image; Individual; Knowledge; Life; Measurement; Measures; Mechanical Stress; Mechanics; Membrane; Methods; Modeling; Operative Surgical Procedures; Outcomes Research; Patient observation; Patients; Periodicity; Physics; Probability; Procedures; Property; Protocols documentation; Research; Residual state; Risk; Risk Assessment; Rupture; Ruptured Abdominal Aortic Aneurysm; Shapes; Stress; Surveillance Program; Testing; Thick; Thrombus; Tissues; Ultrasonography; X-Ray Computed Tomography; abdominal CT; abdominal aorta; abdominal pressure; base; clinical translation; comorbidity; computerized tools; follow-up; indexing; mortality; prevent; prospective; repaired; research study; standard of care; theories

PROJECT SUMMARY / ABSTRACT The overall goal of this problem-driven research is to provide a proof-of-concept strategy for implementing a nonlinear membrane based analysis for abdominal aortic aneurysm (AAA) rupture risk assessment that overcomes the scientific and technological limitations of a finite element analysis (FEA)-based approach. To this end, we propose to develop and apply a method for quantifying rupture potential index (RPI) that does not require knowledge of the tissue properties of the AAA wall and intraluminal thrombus, nor does it need an estimation of the unstressed AAA shape or residual stresses, and does not require an FEA solver. The proposed method is based on nonlinear elastic membrane analysis (NEMA) theory, informed by our prior body of work on geometry quantification of patient-specific AAA models. Therefore, it is a physics-driven method for RPI quantification. We also propose to apply the method while conducting a prospective human subjects research study and assess its potential for rupture risk assessment based on its ability to predict future growth rates. We hypothesize that the new method for calculating RPI will be able to predict future AAA growth rate with a minimum probability of 80%. We will complete the following Specific Aims to accomplish the aforementioned goal and test the proposed hypothesis: (I) Develop a non-FEA approach for calculating RPI; (II) Calculate individual RPI and growth rate for AAAs under surveillance; and (III) Perform a predictive analysis of future AAA growth based on current RPI. The primary expected outcome of this research is a physics-driven method for predicting future AAA growth by calculating RPI using current, standard of care abdominal CT images. The method is devoid of the limitations that characterize typical biomechanics-based approaches. If proven successful, this approach could be envisioned as part of a computational tool for rupture risk assessment in the clinic.

项目摘要 /摘要 这项问题驱动的研究的总体目标是提供实施概念验证策略 基于非线性膜的腹主动脉瘤（AAA）破裂风险评估的分析 克服了有限元分析（FEA）方法的科学和技术局限性。对此 最后，我们建议开发和应用一种量化不需要的破裂电势指数（RPI）的方法 了解AAA壁和腔内血栓的组织特性，也不需要估计 无应力的AAA形状或残余应力，不需要FEA求解器。提出的方法是 基于非线性弹性膜分析（NEMA）理论，由我们先前的几何作品所告知 量化患者特异性AAA模型。因此，这是一种用于RPI定量的物理驱动的方法。我们 还建议在进行前瞻性人类受试者研究研究并评估其时应用该方法 根据其预测未来增长率的能力，破裂风险评估的潜力。我们假设 计算RPI的新方法将能够预测未来的AAA增长率，最小概率为80％。 我们将完成以下具体目标，以实现上述目标并测试提议 假设：（i）开发一种计算RPI的非FEA方法； （ii）计算单个RPI和增长率 AAA在监视下； （iii）基于当前RPI对未来AAA增长进行预测分析。这 这项研究的主要预期结果是一种物理驱动的方法，用于预测未来AAA的增长 使用电流，护理标准的腹部CT图像来计算RPI。该方法没有局限性 这是基于典型的生物力学方法的特征。如果被证明成功，这种方法可能是 作为诊所破裂风险评估的计算工具的一部分。