Polymeric Materials Synthesis and Characterization

高分子材料的合成与表征

基本信息

批准号：
10282409
负责人：
Nathan Claude Gianneschi
金额：
$ 39.81万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-17 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10282409
关键词：
Adsorption Amino Acids Angiogenic Peptides Anti-Inflammatory Agents Binding Biological Assay Biopolymers Cell Culture Techniques Cells Charge Chemical Injury Chemicals Chemistry Clinical Clinical Trials Collaborations Encapsulated Exposure to Exudative age-related macular degeneration Eye Film Formulation Free Radical Scavenging Glycolates Goals Human Immune Immunology In Vitro Inflammation Inflammatory Interleukin-10 Intravenous infusion procedures Laboratories Lead Lipids Liquid substance Mechlorethamine Melanins Microbiology Modeling Modification Mustard Mustard Gas Nature Peptides Play Polymers Porosity Positioning Attribute Preparation Production Property Proteins Redness Retina Role Site Skin Skin injury Solubility Surface System Technology Testing Therapeutic Tissues Transforming Growth Factor beta Translating Universities Validation Vitamin D Work base biocompatible polymer biodegradable polymer carboxylate clinical translation cytokine direct application experimental study improved in vivo innovation interest keratinocyte lead candidate macrophage materials science monocyte monomer nanomaterials nanoparticle novel particle protein aminoacid sequence remediation scale up skin burn small molecule surface coating therapeutic nanoparticles tissue injury tool ultraviolet irradiation uptake

项目摘要

Project Summary The Polymeric Materials Synthesis and Characterizations Core will formulate, synthesize, and characterize lead candidates for the mitigation of mustards and provide support and chemical expertise to other cores and projects. The Core will be co-directed by Drs. Nathan Gianneschi (Dept. of Chemistry) and Stephen Miller (Dept. of Microbiology-Immunology). A tiered approach will be taken to select and optimize such candidates. Initially properties that enhance the efficacy of the materials would be determined and physiochemical analysis on the materials of interest would be probed. One such example is our ability to enrich materials for radical scavenging at the chemical doping level. Other properties would include surface charge, porosity, binding capacity, and solubility of materials. Depending on the material and application for the skin or eyes, the candidate material will be formulated as a nanoparticle, or as a surface coating and the delivery could be optimized for its specific application. That is, materials can be prepared for delivery via direct application as a liquid solution or cast into a film or in the case of PLGA Immune Modifying Particles (PLGA-IMPs) for intravenous infusion. After initial in vitro and in vivo studies, materials will be scaled-up for clinical trials, with many of the proposed systems already known to be amenable to that kind of scale-up. The Polymeric Materials Synthesis and Characterizations Core will be responsible for advancing the synthesis of materials such as polymers from small molecules, will make chemical modifications to improve lead compounds/materials, and will synthesize components for the Lipid- Based Self-Assembled Materials Synthesis and Characterization Core. The goals of this core are to develop formulations and delivery platforms for lead candidates such as melanin, biodegradable polymeric PLGA IMPs (which will be further modified by encapsulating anti-inflammatory cytokines (IL-10 and TGF-β) and compounds (e.g. Vitamin D), and peptide-based delivery systems for the skin and eyes by modifying their physiochemical properties and by characterizing materials for scale-up and clinical translation. For the Polymeric Materials Synthesis and Characterizations Core we propose the following Aims: Aim 1: Utilizing melanin for the remediation and adsorption of mustards; Aim 2: Protein-Like Polymers for treatment of mustard gas in the eye; and Aim 3: Production and characterization of negatively-charged, biodegradable PLGA Immune-Modifying Nanoparticles (PLGA-IMPs) for therapeutic treatment of chemical tissue injury.

项目摘要聚合物材料的合成和特征核心核心将征服，合成和表征铅减轻芥末的候选人，并为其他核心核心和项目提供支持和化学专业知识。核心将由Drs共同执导。微生物学 - 免疫学）。确定提高材料功效的特性，并在生理学上分析感兴趣的材料将被探测到一个这样的例子在化学掺杂水平上。材料的溶解度。作为纳米颗粒配方，或尽可能高达地表面涂层，并且可以优化递送应用。膜或prga imune在初始输注后修饰颗粒（PLGA-IMP）体外研究和体内研究，将对临床试验进行扩展，其中许多支撑系统已知可以适应这种比例。将负责推进材料的合成，例如小分子的聚合物，将使化学修饰以改善铅化合物/材料，并将合成脂质的成分合成基于自组装的材料综合和表征核心。黑色素，可生物降解的聚合PLGA IMPS等铅候选者的配方和交付平台（将通过封装抗炎细胞因子（IL-10和TGF-β）和化合物来进一步修改。（例如，维生素D），通过修饰其物理化学的皮肤和眼睛的基于肽的递送系统通过表征用于扩大和临床翻译的材料。综合和特征核心核心我们提出以下目的：目标1：利用黑色素为它们芥末的修复和吸附和目标3：负电荷，可生物降解的PLGA免疫修饰的生产和表征用于化学组织损伤治疗的纳米颗粒（PLGA-IMP）。