Enhancement of neural regeneration

增强神经再生

基本信息

批准号：
10227962
负责人：
Christian Petersen
金额：
$ 40.1万
依托单位：
NORTHWESTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2023-07-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10227962
关键词：
Address Adult Animals Biological Biological Assay Biological Models Biology Brain Brain region Bromodeoxyuridine Cadherins Cell Transplantation Cells Data Data Set Decapitation Development Disease Engraftment Fatty acid glycerol esters Fluorescent in Situ Hybridization Foundations Genes Genetic Genetic Transcription Genome Goals Grant Histologic In Situ Nick-End Labeling Injury Label Lead Location Logic Medical Methods Molecular Molecular Target Natural regeneration Nerve Regeneration Nervous System Trauma Neurons Organ Organism Pathway interactions Phenotype Phosphotransferases Planarians Platyhelminths Process Production Publishing RNA Interference RNA interference screen Regenerative capacity Regulatory Pathway Signal Transduction Signaling Molecule Specificity Stains System TEC Protein Tyrosine Kinase Testing Time Tissue Transplantation Tissues Transplantation base behavior test cell type experience experimental study gene function information model injury and repair insight mind control neurogenesis novel strategies programs receptor regeneration model regeneration potential regenerative regenerative growth regenerative tissue relating to nervous system repaired restoration single molecule single-cell RNA sequencing stem cell differentiation stem cells targeted treatment tissue regeneration tissue repair transcription factor transcriptome

项目摘要

Project Summary/Abstract Organisms with regenerative abilities have been informative models for uncovering natural mechanisms by which nervous system damage activates stem or progenitor cells for injury repair. The timing, location, and extent of injuries are not predetermined, requiring the existence of mechanisms that instruct tissue restoration activities that perfectly counter the effects of damage. A key question to understand this process is how cessation of regenerative growth is accomplished. To begin to address this question, it is essential to define the transcriptional and cell signaling systems that negatively regulate adult regenerative neurogenesis. While regenerative tissues have been extensively probed for positive regulators of regeneration, much less is known about factors that act in opposition and whose inhibition could lead to enhanced neural regeneration. In the aims of this grant, this deficit is addressed by leveraging expertise in the planarian system, which uniquely allows access to the biology of complete adult brain regeneration. Uncovering the conserved and fundamental mechanisms used by organisms to limit the extent and rate of tissue regeneration and cell turnover will provide foundational insights into understanding and ultimately treating diseases characterized by an inability to undergo sufficient neural repair.

项目概要/摘要具有再生能力的生物体已成为揭示自然机制的信息模型神经系统损伤会激活干细胞或祖细胞进行损伤修复。时间、地点和损伤的程度不是预先确定的，需要存在指导组织修复的机制完全抵消损害影响的活动。理解这个过程的一个关键问题是如何再生生长停止。要开始解决这个问题，有必要定义负调控成人再生神经发生的转录和细胞信号系统。尽管再生组织已被广泛探索再生的正调节因子，但知之甚少关于相反作用的因素以及其抑制可能导致神经再生增强的因素。在根据这笔赠款的目标，这一赤字是通过利用涡虫系统的专业知识来解决的，该系统具有独特的允许了解完整的成人大脑再生的生物学。揭示保守的和基本的生物体用来限制组织再生和细胞更新的程度和速度的机制将提供对理解和最终治疗以无法治疗为特征的疾病的基本见解进行充分的神经修复。