Core C - Administrative Core

核心 C - 行政核心

• 批准号: 10226127
• 负责人: DONALD M COEN
• 金额: $ 5.02万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-02 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10226127
• 关键词: Abnormal coordination; Address; Advisory Committees; Affect; Back; Biological; Chromatin; Clinical; Communication; Ensure; Equilibrium; Feedback; Gene Expression; Herpesvirus 1; Human Resources; Immunobiology; Lead; Leadership; Lytic Phase; Lytic Virus; Manuscripts; MicroRNAs; Microbiology; Monitor; Neurons; Paper; Property; Reagent; Research; Research Personnel; Shipping; Simplexvirus; Telephone; Travel; Viral; Viral Genes; Viral Genome; Viral Proteins; Virus; Virus Diseases; Virus Latency; Work; Writing; adaptive immune response; combat; data sharing; experimental study; fascinate; latent infection; meetings; novel strategies; novel therapeutics; pathogen; prevent; programs; response; symposium; web site

Summary/Abstract – Administrative Core The long-term objectives of this Program Project are to elucidate host and viral mechanisms that tilt the interaction of herpes simplex virus (HSV) and neurons either towards lytic infection or towards latency. HSV latency is the most fascinating biological property of the virus and its most important clinical feature, and understanding HSV latency may lead to new therapies or even a cure for this widespread pathogen. Five different components of the program project -- three projects and two cores -- perform the research to address these objectives. These scientific components are distinct, yet very closely interwoven, so lack of coordination could delay progress. To coordinate and integrate these scientific components, and monitor progress, the Program Directors lead weekly phone conferences and multiple face-to-face meetings of the project and core leaders and more junior personnel to share results and hypotheses, plan experiments, arrange reagent sharing, discuss interpretations, and write papers. At least one meeting each year coincides with a symposium. Both an internal and an external advisory committee provide feedback. The Program Directors also oversee financial matters. Administrative assistants support the program directors in these efforts by arranging phone conferences, meetings, and travel, and helping with shipping of reagents, sharing of data and manuscripts, and with financial oversight. The Administrative Core will also establish a website hosted in the Department of Microbiology and Immunobiology that allows data sharing among all the investigators in the Program Project.

摘要/摘要 - 行政核心 该计划项目的长期目标是阐明宿主和病毒 倾斜疱疹病毒（HSV）和神经元相互作用的机制 要么朝着裂解感染或延迟延迟。 HSV潜伏期是最迷人的 病毒的生物特性及其最重要的临床特征，以及 了解HSV潜伏期可能会导致新疗法，甚至可以治愈 宽度病原体。程序项目的五个不同组成部分 - 三个 项目和两个核心 - 进行研究以解决这些对象。这些 科学组件是不同的，但非常接近交织，因此缺乏协调 可能会延迟进度。协调和整合这些科学组成部分，并 监视进度，计划董事每周举行电话会议和 该项目的多次面对面会议和核心领导者和更多的初级会议 分享结果和假设的人员，计划实验，布置试剂 分享，讨论解释和撰写论文。每年至少一次会议 与研讨会一致。内部和外部咨询委员会 提供反馈。计划董事也在海外财务问题。 行政助理通过安排支持计划董事 电话会议，会议和旅行，并帮助试剂运输， 共享数据和手稿，以及财务监督。行政 核心还将建立一个在微生物学系和 免疫生物学允许该计划中所有调查人员之间的数据共享 项目。