Intellectual and Developmental Disabilities Research Center

智力与发育障碍研究中心

基本信息

批准号：
10224294
负责人：
Michael J Guralnick
金额：
$ 127.18万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-28 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10224294
关键词：
Animal Behavior Animal Model Animals Area Awareness Basic Science Behavioral Bioinformatics Biological Biological Models Brain imaging Cell model Cerebellar malformation Child Clinical Clinical Research Clinical Trials Collaborations Communication Communities Consultations Diagnosis Disease Educational Activities Effectiveness Electrophysiology (science)Environment Epilepsy Equipment Evaluation Faculty Family Fostering Future Genes Genetic Goals Grant Hearing problem Human Human Development Human Subject Research Individual Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Intervention Investigation Leadership Learning Disabilities Magnetic Resonance Magnetic Resonance Spectroscopy Mentors Modality Modeling Nature Newsletter Operative Surgical Procedures Outcome Study Periodicity Pharmaceutical Preparations Positioning Attribute Positron-Emission Tomography Precision therapeutics Research Research Design Research Institute Research Personnel Research Priority Research Project Grants Research Support Research Training Resources Rodent Model Scientist Series Services Structure Study models Subgroup Technical Expertise Techniques Technology Testing Translational Research Universities Washington Work autism spectrum disorder base behavior test behavioral phenotyping brain malformation brain research central nervous system injury design developmental toxicology disability early childhood effective therapy functional genomics human genomics human imaging human model in vivo in vivo imaging innovation interest nonhuman primate prevent programs research data dissemination symposium web site

项目摘要

PROJECT SUMMARY The University of Washington Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center (IDDRC), based at the Center on Human Development and Disability (CHDD), provides a comprehensive interdisciplinary program of basic and translational research designed to prevent, diagnose, and treat individuals with intellectual and developmental disabilities (IDD). Research is carried out within the framework of the following 8 Collaborative Research Areas (CRAs): (1) Biological Basis of Autism; (2) Brain Malformation Disorders; (3) Central Nervous System Injury; (4) Consortium on Early Childhood Intervention; (5) Developmental Toxicology; (6) Epilepsy; (7) Hearing Disorders, and (8) Learning Disabilities. All CRAs are interdisciplinary, include scientists, clinicians, and trainees and are designed to promote translational research. In this application, to facilitate the work of investigators at our IDDRC, we are requesting support for an Administrative Core designed to provide scientific and programmatic leadership and four scientific cores: (1) Genetics -- functional and human genomics and model system components; (2) Brain Imaging -- in vivo imaging for human studies and animal models; (3) Animal Behavior -- behavioral testing for rodent models and consultation for non-human primate models and application of circuit mapping techniques; and (4) Clinical Translational -- promotes and supports clinical and translational research. We are also proposing to conduct a research project focusing on a unique cerebellar malformation utilizing comprehensive- omic approaches that are well integrated with cores and other IDDRC activities. Extensive research training and dissemination activities are also integral components of our IDDRC.

项目摘要华盛顿大学Eunice Kennedy Shriver知识与发展位于人类发展中心的残疾研究中心（IDDRC）和残疾（CHDD），提供了基本和旨在预防，诊断和治疗个人的转化研究智力和发育障碍（IDD）。研究是在以下8个协作研究领域（CRA）的框架：（1）生物学基础自闭症；（2）大脑畸形障碍；（3）中枢神经系统损伤；（4）幼儿干预的财团；（5）发育毒理学；（6）癫痫; （7）听力障碍和（8）学习障碍。所有Cras都是跨学科，包括科学家，临床医生和学员，旨在促进翻译研究。在此应用中，以促进我们的调查人员的工作 IDDRC，我们要求支持旨在提供的行政核心科学和程序化领导以及四个科学核心：（1）遗传学 - 功能和人类基因组学和模型系统成分；（2）大脑成像 - 在人类研究和动物模型的体内成像；（3）动物行为 - 行为测试啮齿动物模型和非人类灵长类动物模型的咨询和咨询电路映射技术的应用；（4）临床翻译 - 促进和支持临床和转化研究。我们还建议进行研究项目的重点是利用全面的小脑畸形 - 与核心和其他IDDRC活动充分融合的OMIC方法。广泛的研究培训和传播活动也是不可或缺的组成部分我们的IDDRC。