Core B: Research and Technical Advancement

核心 B：研究和技术进步

• 批准号: 10221697
• 负责人: RICHARD P. MORRISON
• 金额: $ 41.32万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10221697
• 关键词: Address; Advisory Committees; Animals; Applications Grants; Arkansas; Bioinformatics; Biometry; Cells; Centers of Research Excellence; Communicable Diseases; Complex; Complex Mixtures; Core Facility; DNA Sequencing Facility; DNA sequencing; Data; Data Analyses; Development; Discipline; Disease; Doctor of Philosophy; Ensure; Equipment; Experimental Designs; Experimental Pathology; Flow Cytometry; Fostering; Foundations; Funding; Goals; Grant; Growth; Human; IACUC; Immune response; Inflammatory; Inflammatory Response; Investigation; Journals; Leadership; Learning; Letters; Mammalian Cell; Manuscripts; Medical; Mentors; Microscopy; Mind; Modernization; Molecular Biology; Output; Pathogenesis; Pediatric Hospitals; Phase; Positioning Attribute; Preparation; Process; Productivity; Proteomics; Protocols documentation; Publishing; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Science; Scientist; Seasons; Services; Structure; Teacher Professional Development; Techniques; Therapeutic; Universities; Virulence Factors; Work; career; cellular imaging; data mining; design; editorial; experience; experimental study; genome-wide; instrumentation; interest; large datasets; microbial; microscopic imaging; pathogenic microbe; programs; recruit; research and development; success; tool

PROJECT SUMMARY/ABSTRACT The first goal for the Center for Microbial Pathogenesis and Host Inflammatory Responses during Phase I was to bring together a group of promising young investigators whose research focuses on the complex interactions among diverse microbial pathogens and their common human host and to provide these investigators with the support structure required to establish productive, independent research careers. The second goal was to build on the success of these investigators to expand the program to include additional investigators whose work is consistent with this underlying theme, thereby achieving the critical mass required to establish a self-sustaining Center of Biomedical Research Excellence. The overarching goal of the Center is to promote the ability of these investigators to address problems in infectious disease in a therapeutically relevant fashion by understanding both the microbial virulence factors that contribute to the disease process and how these factors impact the host immunological and inflammatory responses, thereby providing the critical foundation required to manipulate these factors in favor of the host. As described in the Overall component of this Phase II renewal application, we have made tremendous progress toward these goals and are now in strong position to transition from a developmental (Phase I) to a growth stage (Phase II). A key component of this transition is our Administrative and Scientific Development Core (Core A). Specifically, Core A will continue to provide administrative, fiscal, and scientific support for the Center (Aim 1), foster the scientific growth of its investigators through mentoring and faculty development (Aim 2), and foster growth and expansion of the Center through the recruitment of new investigators and facilitating collaborative and synergistic interactions both within the Center and more broadly on the host campuses at large (Aim 3). To these ends, Core A will rely on a seasoned administrative team, the advice of both Internal and External Advisory Committees, and experienced mentors for each Center investigator. The Core's leadership team has fostered the success of Phase I Project Leaders and developed a robust pipeline of new investigators, and during Phase II steps will be taken to ensure the success of these new Project Leaders, promote the continued success of Phase I Project Leaders who obtained R01 funding, maintain the pipeline of new Center investigators, and promote development of collaborative and synergistic research relationships among Center investigators themselves and other scientists on the host campuses (University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute) with common research interests. Success will be judged by the ability to achieve the following milestones in Phase II: 1) obtain no fewer than five new R01- level grants, 2) have at least two Phase I Project Leaders renew grants, 3) publish 25–50 manuscripts in high- impact journals, and 4) have a P01 submitted that includes two or more Center investigators.

项目摘要/摘要 在I期中，微生物发病机理和宿主炎症反应中心的第一个目标 是将一群有前途的年轻调查员汇集在一起​​，他们的研究重点是该综合体 潜水员微生物病原体及其共同的人类宿主之间的相互作用，并提供这些 具有建立生产性独立研究职业所需的支持结构的研究人员。这 第二个目标是建立这些调查人员的成功，以扩大程序以包括附加 研究人员的工作与这个基本主题一致，从而达到所需的临界质量 建立一个自我维持的生物医学研究中心。中心的总体目标是 促进这些研究者在治疗中解决传染病问题的能力 通过了解有助于疾病过程的两个微生物病毒因素，相关方式 这些因素如何影响宿主的免疫学和炎症反应，从而提供 操纵这些因素需要的关键基础以支持宿主。如整体所述 这一第二阶段续订应用的组成部分，我们已经朝着这些目标和 现在处于从发育（I期）到增长阶段（II期）过渡的强大位置。钥匙 这种过渡的组成部分是我们的行政和科学发展核心（核心A）。具体来说，核心 A将继续为中心提供行政，财政和科学支持（AIM 1），促进科学 通过心理和教师发展（AIM 2）的成长，并促进增长和 通过招募新调查人员并支持合作和协作和 中心内部和总体校园内的协同互动（AIM 3）。到 这些目的是，核心A将依靠一个经验丰富的行政团队，这是内部和外部的建议 咨询委员会和每个中心调查员经验丰富的导师。核心的领导团队有 促进了第一阶段项目领导者的成功，并开发了强大的新调查人员管道， 在第二阶段的步骤中，将采取确保这些新项目领导者的成功，促进持续 获得R01资金的第一阶段项目负责人的成功，维护新中心的管道 研究人员，并促进中心之间的协作和协同研究关系的发展 主机校园的调查人员和其他科学家（阿肯色大学医学 具有共同研究兴趣的科学和阿肯色州儿童医院研究所。成功将 通过在II阶段实现以下里程碑的能力来判断：1）获得不少于五个新的R01-- 级别的赠款，2）至少有两个I期项目负责人续签赠款，3）在高级中发布25-50份手稿 影响期刊和4）提交了一个P01，其中包括两个或更多中心调查人员。