Core D. Rodent Behavior Core

核心 D. 啮齿动物行为核心

基本信息

批准号：
10220105
负责人：
Jacqueline N Crawley
金额：
$ 15.32万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-21 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10220105
关键词：
15q 16p11.2 Address Angelman Syndrome Applications Grants Behavior Behavior Therapy Behavioral Behavioral Assay Biological Biological Assay Biological Models Breeding California Clinical Collaborations Communities Consultations Country Data Analyses Development Diagnosis Doctor of Philosophy Down Syndrome Ensure Experimental Designs Face Faculty Family Female Foundations Fragile X Syndrome Funding Genetic Genotype Goals Human Human Resources Immune system Immunologics Institutes Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability International Leadership Learning Life Cycle Stages Manuscripts Mediating Methods Mission Modeling Mus Neurobiology Outcome Measure Phelan-McDermid syndrome Prevention Procedures Productivity Protocols documentation Publications Quality of life Rattus Reproducibility Research Research Design Research Personnel Research Project Grants Research Support Rett Syndrome Risk Factors Rodent Rodent Model Services Standardization Supervision Symptoms System Training Translational Research United States National Institutes of Health Universities autism spectrum disorder behavior test behavioral outcome behavioral phenotyping career cohort design experimental study improved innovation insight male mouse model neurobehavioral novel pre-clinical research relating to nervous system sex

项目摘要

PROJECT SUMMARY – RODENT BEHAVIOR CORE The present application seeks funding to continue the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013 and is the newest of the 14 IDDRCs in the network. The goal of the RBC is to support IDDRC projects using translational rat and mouse models to advance understanding and treatment of the behavioral outcomes of genetic, neuroanatomical, immunological, and environmental causes of IDDs. The RBC is designed to address three specific aims. Aim 1 is to provide innovative, high quality, state-of-the-art behavioral testing of mice and rats to enhance the quality and productivity of IDD research. The RBC will address this aim by offering a comprehensive battery of neurobehavioral assays and related services, with tiers of service ranging from consultation to full implementation of the study by RBC staff. Aim 2 is to provide learning opportunities for trainees and faculty to become expert in rodent behavioral testing procedures, experimental design, and accurate interpretation of data. This aim will be addressed by RBC staff offering involvement in the life cycle of each study, from initial consultation in study design and selection of assays to hands-on training and supervision in implementation of assays to consultation on data interpretation and input on manuscripts and grant applications. Aim 3 is to contribute to the IDDRC network in disseminating best practices and standardizing rodent behavioral testing protocols. This aim will be addressed by leveraging the internationally recognized expertise of the RBC leadership in mouse and rat behavior assays to develop collaborations and consultations with other IDDRC Rodent Cores; to participate in cross-IDDRC training of core personnel on novel, specialized behavioral assays; and to validate standardized protocols for rodent behavioral assays. Infused in all activities of the RBC as it addresses these aims is the imperative for rigor and reproducibility in preclinical research. The RBC strives to ensure that all IDDRC studies include the necessary control assays, conduct two or more corroborative assays within a behavioral domain, replicate findings in a second independent cohort, use breeding strategies to obtain genotype controls, employ group sizes sufficient to achieve statistical power, and use males and females to address sex as a biological variable. The Director of the RBC is Jacqueline Crawley, PhD.

项目摘要 – 啮齿动物行为核心本申请寻求资金以继续 MIND 研究所智力与发展加州大学戴维斯分校残疾人研究中心 (IDDRC) 于 2013 年成立。是网络中 14 个 IDDRC 中最新的一个。RBC 的目标是支持使用 IDDRC 项目。转化大鼠和小鼠模型，以促进对行为结果的理解和治疗 RBC 旨在解决 IDD 的遗传、神经解剖学、免疫学和环境原因。三个具体目标是提供创新、高质量、最先进的小鼠行为测试 RBC 将通过提供一个解决方案来实现这一目标。全面的神经行为检测和相关服务，服务级别包括目标 2 是为 RBC 工作人员提供学习机会。学员和教师成为啮齿动物行为测试程序、实验设计和准确解释数据的目标将由 RBC 工作人员参与生命周期来实现。每项研究，从研究设计的初步咨询和分析方法的选择到实践培训和监督实施分析以咨询数据解释以及手稿和拨款的输入目标 3 是为 IDDRC 网络传播最佳实践和标准化做出贡献。啮齿动物行为测试协议将通过利用国际公认的方法来实现。 RBC 领导层在小鼠和大鼠行为测定方面的专业知识，以开展合作和咨询与其他 IDDRC 啮齿类核心人员一起参加 IDDRC 核心人员的新颖、专业培训行为测定；并验证所有活动中注入的啮齿动物行为测定的标准化方案。 RBC 在解决这些目标时对临床前研究的严谨性和可重复性至关重要。 RBC 努力确保所有 IDDRC 研究包括必要的对照测定，进行两项或多项测定行为领域内的确证测定，在第二个独立队列中复制研究结果，使用育种获得基因型控制的策略，采用足以实现统计功效的群体规模，并使用男性 RBC 主任杰奎琳·克劳利 (Jacqueline Crawley) 博士。