Evaluating a Combined Communication and Counseling Intervention in Primary Progressive Aphasia: A Pilot Feasibility Study

评估原发性进行性失语症的联合沟通和咨询干预：试点可行性研究

• 批准号: 10267689
• 负责人: Kristin Marie Schaffer
• 金额: $ 3.26万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-16 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10267689
• 关键词: Acute; Address; Aftercare; American; American Speech-Language-Hearing Association; Aphasia; Area; Award; Behavior; Behavioral Sciences; Brain; Brain Injuries; Clinical; Clinical Psychology; Cognitive Therapy; Cohort Effect; Cohort Studies; Communication; Communication impairment; Competence; Complement; Confidence Intervals; Counseling; Data; Data Analyses; Development; Disease Progression; Educational Intervention; Emotional; Etiology; Experimental Designs; Face; Feasibility Studies; Feedback; Fellowship; Foundations; Future; Goals; Grant; Health; Individual; Intervention; Interview; Language; Language Disorders; Learning; Life; Linguistics; Literature; Manuals; Methodology; Methods; Mission; Moods; Nerve Degeneration; Nervous System Trauma; Neurodegenerative Disorders; Neurogenic Communication Disorders; Neurologic; Outcome; Outcome Measure; Participant; Pathologist; Patients; Population; Primary Progressive Aphasia; Procedures; Progressive Aphasias; Psychosocial Influences; Public Health; Qualitative Research; Quality of life; Rehabilitation therapy; Reporting; Research; Research Methodology; Research Personnel; Sample Size; Services; Speech; Speech-Language Pathology; Statistical Data Interpretation; Stroke; Techniques; Thinking; Training; Treatment outcome; United States National Institutes of Health; Vision; Vulnerable Populations; Well in self; acceptability and feasibility; career; clinical diagnosis; cohort; design; disability; efficacy research; experience; falls; health related quality of life; improved; language outcome; lexical retrieval; meetings; member; nervous system disorder; novel; primary outcome; psychosocial; recruit; satisfaction; stakeholder perspectives; statistics; study population; treatment research

Project Summary Aphasia is a neurogenic communication disorder caused by damage to language regions in the brain, including acute neurological insult or neurodegenerative disease.1 Given that the ability to communicate is entwined with identity, competency, and self-expression, the advent of aphasia often results in negative psychosocial repercussions.2 Individuals with primary progressive aphasia (PPA) are an especially vulnerable population, as they face an ongoing and inevitable decline in communication ability with disease progression. While there is a growing body of research pertaining to the utility of speech-language intervention for PPA, counseling approaches that address the emotional needs of this clinical population are under-studied. In this study, we propose to implement psychosocial approaches alongside speech-language intervention for individuals with PPA. Specifically, we will analyze the acceptability and feasibility of a novel intervention that implements aphasia-modified cognitive behavioral therapy (CBT) approaches alongside tailored speech- language treatment (i.e., script training or lexical retrieval training) in a group of nine participants with mild PPA. During the study, we will refine a novel, aphasia-adapted CBT manual and will conduct mixed methods analyses to contextualize preliminary treatment outcomes. Additionally, we will complete exploratory analyses comparing speech-language and psychosocial outcomes from the proposed study cohort to a speech-language intervention-only cohort as an initial characterization of treatment benefit. This study will serve as an important preliminary stage in a programmatic line of research, setting the stage for larger-scale efficacy research. This project will advance the science of behavioral rehabilitation in aphasia by providing evidence regarding holistic treatment that not only addresses communication impairment, but also incorporates counseling techniques that empower patients to optimally navigate the psychosocial challenges associated with aphasia. This is relevant to public health, as aphasia directly impacts an estimated 2-4 million Americans.27 The aims of this proposal are in direct alignment with the mission of the NIH, as this project endeavors to minimize disability and improve the lives of those who have been impacted by a neurological disorder. This fellowship will provide the applicant with a multifaceted training experience with opportunities to learn new research methodologies, data analysis procedures, and clinical principles. The applicant’s sponsor and contributing members of the training team possess expertise in distinct yet complementary research and clinical areas, including quantitative and qualitative research, experimental design, statistical analysis, speech-language intervention, and counseling methodologies. Taken together, this comprehensive, interdisciplinary training experience will support the applicant in meeting the research aims of this grant and will prepare her to become an independent aphasia researcher.

项目概要 失语症是一种神经源性沟通障碍，由大脑语言区域受损引起，包括 急性神经损伤或神经退行性疾病。1 鉴于沟通能力与 身份、能力和自我表达方面，失语症的出现往往会导致消极的社会心理 影响。2 原发性进行性失语症 (PPA) 患者是特别脆弱的人群，因为 随着疾病的进展，他们的沟通能力会持续且不可避免地下降。 越来越多的研究涉及语音语言干预对 PPA、咨询的效用 解决该临床人群情感需求的方法尚未得到充分研究。 在这项研究中，我们建议在言语干预的同时实施心理社会方法 具体来说，我们将分析一种新颖干预措施的可接受性和可行性。 实施失语症改良认知行为治疗（CBT）方法以及定制的言语治疗 对 9 名轻度 PPA 参与者进行语言治疗（即脚本训练或词汇检索训练）。 在研究期间，我们将完善一本新颖的、适合失语症的 CBT 手册，并将进行混合方法分析。 此外，我们将完成探索性分析比较。 从拟议的研究队列到言语语言的言语和心理社会结果 仅干预队列作为治疗益处的初步表征，这项研究将作为一项重要的研究。 纲领性研究的初步阶段，为更大规模的功效研究奠定了基础。 该项目将通过提供以下方面的证据来推进失语症行为康复的科学 整体治疗不仅解决沟通障碍，还包括咨询 使患者能够最佳地应对与失语症相关的心理社会挑战的技术。 这与公共健康相关，因为失语症直接影响估计 2-400 万美国人。 27 该提案与 NIH 的使命直接一致，因为该项目致力于最大限度地减少残疾 并改善那些受神经系统疾病影响的人的生活。 该奖学金将为申请人提供多方面的培训经验以及学习新知识的机会 研究方法、数据分析程序和临床原则。 培训团队的贡献成员拥有独特但互补的研究和临床专业知识 领域，包括定量和定性研究、实验设计、统计分析、语音语言 综合干预和咨询方法，这种全面的、跨学科的培训。 经验将支持申请人实现这笔资助的研究目标，并帮助她做好成为 独立失语症研究者。