Harnessing the power of experimental genetic crosses and systems genetics to probe drug resistance in malaria

利用实验遗传杂交和系统遗传学的力量来探测疟疾的耐药性

• 批准号: 10216642
• 负责人: Michael T Ferdig
• 金额: $ 9.3万
• 依托单位: UNIVERSITY OF NOTRE DAME
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10216642
• 关键词: Address; Area; Budgets; Calendar; Chromosome Mapping; Collaborations; Communication; Communities; Data; Data Analyses; Decision Making; Drug resistance; Electronic Mail; Ensure; Evaluation; Event; Experimental Genetics; Faculty; Feedback; Frequencies; Funding; Genetic; Genetic Crosses; Goals; Grant; Human Resources; Individual; Internet; Leadership; Letters; Malaria; Modification; Monitor; Positioning Attribute; Preparation; Process; Productivity; Program Research Project Grants; Program Reviews; Recommendation; Records; Reporting; Research; Research Personnel; Resources; Sampling; Schedule; Science; Site; Structure; Supervision; System; Systems Biology; Texas; Time; Travel; United States National Institutes of Health; Universities; base; cloud based; data sharing; design; falls; genetic linkage; interest; meetings; member; operation; payment; performance site; programs; response; symposium; virtual

ABSTRACT The Administrative Core (Admin Core) based at the University of Notre Dame (UND) will ensure that the Program Project grant (P01) PI and Admin Core Director (AD)(Ferdig) is positioned to supervise and administer the P01. The Admin Core will facilitate communication and interaction between all groups and will thus ensure that the three physically separate sites will function as a virtual single site. The AD, with assistance from the Admin Core Program Manager (PM), will function to coordinate the overall scientific direction and will monitor ongoing productivity of the P01 and communicate the activities to the Advisory Boards. In its administrative capacity, the Admin Core will centralize program-wide information, provide administrative support to program investigators, and maintain records relating to P01 progress. Ferdig will participate and manage at all levels of communication and is responsible for all aspects of effective operations and collaborative decision-making with the Leadership Team (LT). The AD, with the assistance of a PM and the LT, consisting of all Project Leads and Core Directors, will function to centralize program-wide information and to coordinate the overall direction of the P01 with feedback from an Internal Advisory Board (IAB) and an External Advisory Board (EAB). The IAB will evaluate ongoing progress towards P01 goals and provide recommendations for alternative strategies to P01 activities if modifications are indicated. Members of the IAB will consist of distinguished expert faculty at the three performance sites (UND, Texas Biomed and CID Research). The EAB will guide and evaluate the overall impact and productivity of the program in alignment with the broader scientific community in the areas of the P01. The EAB will be formed in communication with NIH Program advisors and will consist of worldwide experts on classical genetics, linkage mapping, systems biology, malaria and drug resistance.

抽象的 巴黎圣母院（UND）的行政核心（管理员核心）将确保 计划项目赠款（P01）PI和Admin Core董事（AD）（Ferdig）的定位用于监督和 管理P01。管理员核心将促进所有组之间的沟通和互动，将 因此，请确保三个物理分开的站点将充当虚拟单位站点。广告，协助 从管理员核心计划经理（PM）中，将运行以协调整体科学方向，并将 监视P01的持续生产力，并将活动传达给咨询委员会。在它的 管理能力，管理员核心将集中计划范围内的信息，提供管理 支持计划调查人员，并维护与P01进度有关的记录。 Ferdig将参加， 管理各个级别的沟通，并负责有效操作的各个方面 与领导团队（LT）合作决策。 在PM和LT的协助下，该广告由所有项目负责人和核心董事组成，将 功能以集中计划范围的信息并与反馈协调P01的整体方向 来自内部顾问委员会（IAB）和外部顾问委员会（EAB）。 IAB将评估正在进行的 朝着P01目标迈进，并为P01活动提供替代策略的建议 表示修改。 IAB的成员将由三个的杰出专家教师组成 性能站点（UND，德克萨斯州生物膜和CID研究）。 EAB将指导和评估总体 该计划的影响和生产力与更广泛的科学界保持一致 P01。 EAB将在与NIH计划顾问的沟通中形成，并将由全球组成 经典遗传学，链接图，系统生物学，疟疾和耐药性专家。