Administrative and Statistical Core Resource

行政和统计核心资源

• 批准号: 10217468
• 负责人: JOHN M MARIS
• 金额: $ 18.4万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-20 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10217468
• 关键词: Address; Administrator; Advocate; Basic Science; Budgets; Child; Childhood; Clinical Research; Collaborations; Communication; Complex; Development; Goals; High-Risk Cancer; Immunotherapeutic agent; Immunotherapy; Interdisciplinary Study; Investigation; Lead; Leadership; Malignant Childhood Neoplasm; Mission; Office of Administrative Management; Principal Investigator; Records; Reproducibility; Research; Research Project Grants; Resources; Shapes; Time; Translational Research; Work; anticancer research; design; experience; meetings; multidisciplinary; operation; programs

CORE A SUMMARY/ABSTRACT Our proposed U54 Center application entitled Discovery and Development of Optimal Immunotherapeutic Strategies for Childhood Cancers is a multi-disciplinary and multi-institutional effort that we think is directly responsive to the RFAs designed to create the Pediatric Immunotherapy Discovery and Development Network (PI-DDN). Built on years of multi-disciplinary collaboration amongst Project and Core Principal Investigators and their research teams, we plan to directly address critical unmet needs uniquely relevant to children with high-risk cancers. To accomplish our Center goals, we propose experienced leadership to define priorities, sustain momentum and deliver results that meet defined milestones on time and under budget. The proposed co-PIs Drs. Maris and Mackall have worked together to lead complex research programs and coordinate integrated and collaborative experimentation. Here, we propose an administrative Core that will provide the scientific, statistical and administrative leadership to achieve the mission of the proposed investigation. With experienced statistical and administrative support, we will organize the recurring meetings and day-to-day operation of the Center and interactions with the PI-DDN and other immunotherapy efforts. The Core will support the scientific interchange necessary for the ambitious scientific goals of each Project and the Center as a whole, encourage input from pediatric cancer advocates to help shape our mission, oversee the allocation of budget on a quarterly basis as our research evolves, assure regulatory compliance, and promote experimental rigor and transparency.

核心摘要/摘要 我们提出的U54中心申请名为“发现和开发最佳免疫治疗” 儿童癌症的策略是我们认为直接的多学科和多机构的努力 响应旨在创建儿科免疫疗法发现和开发网络的RFA （pi-ddn）。建立在项目和核心主要研究人员之间多年的多学科合作之上 以及他们的研究团队，我们计划直接解决与具有 高风险癌症。为了实现我们的中心目标，我们建议有经验的领导才能定义优先事项， 维持动力并提供符合定义里程碑的结果，并在预算下按预算。提议 Co-Pis Drs。马里斯和麦克尔共同领导复杂的研究计划并协调 集成和协作实验。在这里，我们提出了一个行政核心，该核心将提供 科学，统计和行政领导，以实现拟议调查的使命。和 经验丰富的统计和行政支持，我们将组织重复的会议和日常 中心的运行以及与PI-DDN和其他免疫疗法工作的相互作用。核心意愿 支持每个项目和中心雄心勃勃的科学目标所必需的科学互换 整体，鼓励小儿癌症倡导者的意见，以帮助塑造我们的任务，监督分配 随着我们的研究的发展，确保法规合规性并促进实验性，每季度预算预算 严格和透明度。