Northwestern CORE Clinical Research Site: Trans-omics for HIV/AIDS Research

西北核心临床研究站点：艾滋病毒/艾滋病研究的跨组学

基本信息

批准号：
10223024
负责人：
Steven M Wolinsky
金额：
$ 4.38万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-10 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10223024
关键词：
AIDS/HIV problem Active Sites Address Advocacy Aging Basic Science Behavior Big Data Biological Assay Biological Factors Biological Markers Biological Process Biology Blood Blood specimen Catalogs Cells Chronic Clinical Clinical Research Cohort Studies Collaborations Collection Communities Complement Complex County Data Data Analyses Data Collection Data Set Development Diagnosis Disease Disease Outcome Disease model Enrollment Ensure Epidemic Event Funding Gene Expression Gene Expression Profile Genes Genetic Genetic Determinism Genetic Risk Genome Genotype Goals HIV HIV Infections Health Health Insurance Portability and Accountability Act Health Policy Healthcare Heritability Hospitals Human Image Immune System Diseases Immune response Infection Inflammation Inflammation Mediators Inflammatory Information Technology Informed Consent Infrastructure Interdisciplinary Study Knowledge Laboratories Lead Leadership Link Maintenance Measures Medical Records Modeling Modeling of Functional Interactions Molecular Profiling Office of Administrative Management Outcome Participant Pathogenicity Pathway Analysis Pathway interactions Pattern Pharmaceutical Preparations Phenotype Play Policies Policy Developments Practice Guidelines Precision Medicine Initiative Predisposition Procedures Production Property Prospective Studies Protocols documentation Psychosocial Factor Public Health Quality Control Recording of previous events Reporting Reproducibility Research Research Priority Research Project Grants Resources Risk Role Running Science Scientific Advances and Accomplishments Scientist Severity of illness Signal Pathway Signaling Protein System Testing Tissues Training United States National Institutes of Health Universities Variant Virus Virus Replication Work adjudicate adjudication base clinical care clinical research site co-infection cohort comorbidity cooking data integration epidemiology study flexibility follow-up functional genomics genetic variant good laboratory practice immune activation improved inclusion criteria innovation insight microbiome multidisciplinary new therapeutic target next generation novel participant retention predictive modeling programs protein expression protein protein interaction quality assurance repository response risk variant sample collection social science research vaccine development virus host interaction

项目摘要

The Northwestern University and the Ruth M. Rothstein CORE Center of the Cook County Health & Hospitals System Clinical Research Site (NC CRS) addresses the highest research priorities in HIV/AIDS research through retention and maintenance of the cohort, collection and repository storage of blood samples, and development and implementation of the unified science agenda. Through the leadership we provide and the data and blood samples we collect, the NC CRS actively contributes to core protocols and thematic sub- studies to characterize the long-term, natural and treated history of HIV infection in a representative cohort of people at substantial risk of becoming infected with the virus. We strictly adhere to good practice guidelines, established policies and procedures, and robust quality assurance and quality control measures to ensure the accuracy, reproducibility, and integrity of the clinical and laboratory data and blood samples. Scientific and administrative management provides both the flexibility and means to conduct multidisciplinary research projects as well as the resources to respond rapidly to recent scientific progress. For the past 35 years, we have maintained a comprehensive portfolio of biomedical and social science research on HIV and its related coinfections, comorbidities, and other complications. The diversity of the work makes possible a broad and multidisciplinary view of these high priority topics for understanding the basic biology of HIV, immune dysfunction and chronic inflammation, and genetic determinants. Scientific questions take full advantage of the strengths of the cohort, namely, its duration and the continuity of data and blood samples that timespan provides. Data and blood samples are available from people before and after infection, before and after beginning medications, or before and after the development of comorbidities or their complications. Productive relationships across the combined cohort, as well as other consortia and organizations, have coalesced around specific issues to advance scientific knowledge, the health of people, and policy development. By capitalizing on the expertise and unique resources of a multidisciplinary team of experts, we will build on our studies of genome sequence, patterns of gene and protein expression, and metabolite concentrations and changes (trans-omics dataset), along with information from people's medical records, to identify genes and pathways that play a role in disease and determine how they interact with HIV. Hierarchal models that predict the network behavior that gives rise to a phenotype will unravel the complexity of disease to provide novel and important insights into biological processes for testing or generating a set of hypotheses about disease mechanisms. During the next 7-year funding cycle, the NC CRS will continue support for the cohort and trans- omics for HIV/AIDS research that complements and extends the NIH Precision Medicine Initiative that connects genotype and phenotype and aligns with the NIH Big Data Initiative that supports innovative and transformative approaches to advance understanding of human health and disease.

西北大学和库克县健康与医院的露丝·M·罗斯斯坦核心中心系统临床研究站点（NC CRS）涉及艾滋病毒/艾滋病研究的最高研究优先事项通过保留和维护队列，收集和存储库的血液样本存储，以及统一科学议程的发展和实施。通过我们提供的领导和我们收集的数据和血液样本，NC CRS积极促进核心方案和主题子协议在代表性队列中表征艾滋病毒感染的长期，自然和治疗史的研究患有病毒感染的人有很大的风险。我们严格遵守良好的练习指南，建立的政策和程序，以及良好的质量保证和质量控制措施，以确保临床和实验室数据和血液样本的准确性，可重复性和完整性。科学和行政管理提供了进行多学科研究的灵活性和手段项目以及对最近科学进步做出迅速反应的资源。在过去的35年中，我们维持有关艾滋病毒及其相关的生物医学和社会科学研究的全面组合共同感染，合并症和其他并发症。这项工作的多样性使得可能成为可能的广泛和这些高优先级主题的多学科观点，用于了解艾滋病毒的基本生物学，免疫功能障碍和慢性炎症和遗传决定因素。科学问题充分利用了队列的优势，即其持续时间以及时间段的数据和血液样本的连续性提供。感染前后，在感染之前和之后的人可以找到数据和血液样本开始药物，合并症或其并发症的发展之前和之后。生产力整个组合队列的关系以及其他财团和组织都融合了具体问题，以提高科学知识，人的健康和政策发展。通过大写关于多学科专家团队的专业知识和独特资源，我们将在研究基础上基因组序列，基因和蛋白质表达的模式以及代谢物浓度和变化（Trans-Omics数据集）以及来自人们病历的信息，以识别基因和途径该在疾病中发挥作用，并确定它们与艾滋病毒的相互作用。层次模型预测引起表型的网络行为将揭示疾病的复杂性，以提供新颖和对测试或产生有关疾病的一组假设的生物学过程的重要见解机制。在接下来的7年资金周期中，NC CRS将继续支持队列和反式。艾滋病毒/艾滋病研究的OMICS，与NIH Precision Medicine Anitiative相辅相成连接基因型和表型，并与支持创新和的NIH大数据计划保持一致推进对人类健康和疾病的理解的变革性方法。