CORALE-SeroNet Immune Bioanalytics Core

CORALE-SeroNet 免疫生物分析核心

基本信息

批准号：
10222435
负责人：
Jennifer E Van Eyk
金额：
$ 85.33万
依托单位：
CEDARS-SINAI MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10222435
关键词：
2019-nCoV Acute-Phase Proteins Anti-Inflammatory Agents Antigen-Antibody Complex Biochemical Biochemistry Biological Assay Biological Process Biological Response Modifiers COVID-19 pandemic Clinical Research Core Facility Development Devices Disease Early identification Eicosanoids Endothelial Cells Ensure Equilibrium Exhibits Foundations Goals Human Immune Immunologic Factors Immunology procedure Individual Infection Inflammation Inflammation Mediators Inflammatory Inflammatory Response Infrastructure Investigation Leukotrienes Lipoxins Mass Spectrum Analysis Measures Metabolic syndrome Methods Obesity Organization and Administration Outcome Pathway interactions Patients Peptides Physiological Plasma Play Population Population Study Predisposition Prostaglandins Proteins Reproducibility Research Research Personnel Resolution Resource Sharing Resources Risk Sampling Science Serological Severities Severity of illness System Therapeutic Thrombosis Thromboxanes Work absorption advanced analytics adverse outcome combat complex data cytokine data exchange data integration data standards effective therapy immune function mortality mortality risk novel novel therapeutic intervention organ injury protein metabolite response tissue injury

项目摘要

ABSTRACT The Immune Bioanalytics Core (IBC) will serve as a critical Shared Resource Core for our U54 SARS-CoV-2 Serological Sciences Center of Excellence. This centralized resource will provide state-of-the-art infrastructure and expertise in high resolution, directed mass spectrometry for the robust and precise measure of over 500 immune mediators - including immune-modulatory proteins, acute phase proteins, cytokines and eicosanoids – across thousands of human biosamples. This IBC will be responsible for automated sample handling and curation for a number of sample types, protein and metabolite extraction, mass spectrometry and biochemical assay of immune factors, complex data integration, and data transfer, in support of the U54 Projects. As part of the larger SeroNet U54 Centers for Excellence, the IBC will further provide capacity and expertise for measure of immune-modulatory peptides and eicosanoids factors for all SeroNet investigators, as well as provide close assistance with data standardization and cross-Center integration.

抽象的免疫生物分析核心（IBC）将成为我们U54 SARS-COV-2的关键共享资源核心血清学科学卓越中心。这种集中资源将提供最先进的基础架构以及高分辨率的专业知识，定向质谱法，可鲁棒和精确测量超过500 免疫介质 - 包括免疫调节蛋白，急性相蛋白，细胞因子和类花生酸酯 - 跨越成千上万的人类生物样本。该IBC将负责自动样品处理和多种样品类型，蛋白质和代谢物提取，质谱和生化的策划用于支持U54项目的免疫因素，复杂的数据集成和数据传输的ADSAME。作为 IBC较大的Seronet U54卓越中心将进一步提供测量能力和专业知识所有Seronet研究者的免疫调节肽和类花生素因素，并提供关闭协助数据标准化和跨中心集成。