CORALE-SeroNet Recruitment and Biobanking Core

CORALE-SeroNet 招聘和生物样本库核心

• 批准号: 10222434
• 负责人: Jane C. Figueiredo
• 金额: $ 93.95万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10222434
• 关键词: 2019-nCoV; African American; Ambulatory Care Facilities; Antibodies; Asians; Bioinformatics; Blood; COVID-19; California; Catchment Area; Clinical; Clinical Data; Clinics and Hospitals; Cohort Studies; Collaborations; Collection; Communities; Consent; Data; Data Analytics; Data Reporting; Databases; Diagnosis; Electronic Health Record; Electronic Mail; Employee; Enrollment; Epidemiologist; Epidemiology; Evaluation; Evaluation Studies; Funding; Geographic Locations; Goals; Hawthorne Effect; Health Personnel; Heart; Hispanics; Home environment; Household; Immune; Immune response; Immunocompromised Host; Individual; Infection; Inflammatory Response; Infrastructure; Institution; Laboratories; Latino; Link; Los Angeles; Malignant Neoplasms; Medical; Medical Records; Medical center; Methodology; Outcome; Participant; Pathologist; Patient Recruitments; Patients; Population; Population Heterogeneity; Procedures; Process; Protocols documentation; Questionnaires; Records; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk; Serological; Specimen; Standardization; System; Technology; Testing; Time; Translational Research; Virus; base; biobank; clinically relevant; cohort; cost efficient; data harmonization; data management; data sharing; design; digital; experience; fight against; follow-up; genetic linkage analysis; laboratory equipment; member; novel virus; pandemic disease; patient oriented; patient portal; programs; prospective; recruit; response; routine screening; sample collection; user-friendly; virtual

PROJECT SUMMARY/ABSTRACT for the Recruitment and BioBanking Core The Recruitment and Biobanking Core (RBC) will serve as a Resource Support Core for 3 full Research Projects. This core provides a standardized system for patient identification and recruitment, longitudinal follow- up using active and passive methodologies, biospecimen collection, tracking, processing, storage, and distribution; access to state-of-the-art laboratory technologies provided in Core 2; linkage to medical records and other relevant external databases; computational and statistical support; and enables future research in collaboration with SeroNET and beyond. Importantly, this core leverages already implemented cutting-edge initiatives underway at Cedars-Sinai, namely: (1) Biobanking Research Protocol that universally permits patients to participate in research by utilizing and storing their biospecimens and conducting follow-up procedures for research purposes; (2) Cedars-Sinai Accelerator which has funded start-up companies (e.g., Hawthorne Effect) to develop and implement integrated technological platforms to provide timely, accurate data from patients as well as networks to facilitate remote data and biospecimens collections; and (3) Cedars-Sinai’s Employee Cohort that has conducted timely repeated questionnaire assessments, repeated biospecimen collection and repeated SARS-CoV-2 testing on >6,000 Essential Health Care Workers. The RBC will merge these activities into a centralized approach with the following goals: 1. Expand Recruitment and Prospective Follow-Up: Cedars-Sinai COVID-19 Risk Associations and Longitudinal Evaluation (CORALE) study leverages the expansive Cedars- Sinai network including two large medical centers and multiple outpatient clinics. The fully integrated Epic based electronic health record (EHR), known as CS-Link, allows for rapid connection with over >1M individuals and permits digital enrollment, consent and data entry and tracking via a virtual patient portal. Cedars-Sinai’s diverse catchment area in central Los Angeles allows a unique opportunity, unparalleled in other parts of the U.S., to bring together large diverse populations (including large numbers of Hispanics/Latinos and African Americans). Electronic communication, data entry and remote biospecimen collection capabilities enable rapid and cost- efficient longitudinal follow-up. 2. Biospecimen Collection, Processing and Storage: We will collect, process, store, and track all biospecimens using LabvantageTM, a user-friendly laboratory tracking system already implemented and supported directly by the Cedars-Sinai Biobank and Translational Research Core Laboratory. 3. Data Management, Linkage and Analyses: We will link demographic, clinical, epidemiologic, and outcomes data from our centralized EHR with the biospecimens and participant reported data. Our bioinformatic and computational shared resources will provide analytical support. 4. Expand Capacities for Future Research: We will provide access to state-of-the-art technologies available through the integration of our Core with our existing Shared Resources and enable data sharing with internal and external investigators in SeroNET.

招聘和生物样本库核心项目摘要/摘要 招募和生物样本库核心 (RBC) 将作为 3 个完整研究的资源支持核心 该核心项目提供了一个用于患者识别和招募、纵向随访的标准化系统。 使用主动和被动方法、生物样本收集、跟踪、处理、存储和 分发；获得核心 2 中提供的最先进的实验室技术； 其他相关的外部数据库；并支持未来的研究； 重要的是，该核心利用了已经实现的尖端技术。 Cedars-Sinai 正在进行的举措，即： (1) 普遍允许患者的生物样本库研究协议 通过利用和储存生物样本并进行后续程序来参与研究 (2) Cedars-Sinai Accelerator，资助初创公司（例如霍桑效应） 开发和实施综合技术平台，以提供及时、准确的患者数据 以及促进远程数据和生物样本收集的网络；以及 (3) Cedars-Sinai 的员工队列； 及时进行重复问卷评估、重复生物样本采集和重复采集 RBC 将对超过 6,000 名基本卫生保健工作者进行 SARS-CoV-2 测试。 集中式方法，目标如下： 1. 扩大招募和前瞻性后续行动：Cedars-Sinai COVID-19 风险关联和纵向评估 (CORALE) 研究利用了不断扩大的 Cedars- 西奈网络包括两个大型医疗中心和多个基于 Epic 的完全集成的门诊诊所。 电子健康记录 (EHR)，称为 CS-Link，可以与超过 100 万人快速连接， 允许通过 Cedars-Sinai 的多元化虚拟患者门户进行数字注册、同意、数据输入和跟踪。 洛杉矶市中心的集水区提供了美国其他地区无可比拟的独特机会 汇集了大量不同的人口（包括大量西班牙裔/拉丁裔和非裔美国人）。 电子通信、数据输入和远程生物样本采集功能可实现快速且成本低廉的 2. 生物样本收集、处理和储存：我们将收集、处理、 使用 Labvantage™（用户友好的实验室跟踪系统）存储和跟踪所有生物样本 由雪松-西奈生物库和转化研究核心实验室直接实施和支持。 3. 数据管理、关联和分析：我们将把人口统计、临床、流行病学和结果联系起来 来自我们集中式 EHR 的数据以及生物样本和参与者报告的数据。 计算共享资源将提供分析支持。 扩大未来研究的能力：我们。 将通过我们的核心与现有的集成提供最先进的技术 共享资源并在 SeroNET 中与内部和外部研究人员共享数据。