CORALE-SeroNet Recruitment and Biobanking Core

CORALE-SeroNet 招聘和生物样本库核心

• 批准号: 10222434
• 负责人: Jane C. Figueiredo
• 金额: $ 93.95万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10222434
• 关键词: 2019-nCoV; African American; Ambulatory Care Facilities; Antibodies; Asians; Bioinformatics; Blood; COVID-19; California; Catchment Area; Clinical; Clinical Data; Clinics and Hospitals; Cohort Studies; Collaborations; Collection; Communities; Consent; Data; Data Analytics; Data Reporting; Databases; Diagnosis; Electronic Health Record; Electronic Mail; Employee; Enrollment; Epidemiologist; Epidemiology; Evaluation; Evaluation Studies; Funding; Geographic Locations; Goals; Hawthorne Effect; Health Personnel; Heart; Hispanics; Home environment; Household; Immune; Immune response; Immunocompromised Host; Individual; Infection; Inflammatory Response; Infrastructure; Institution; Laboratories; Latino; Link; Los Angeles; Malignant Neoplasms; Medical; Medical Records; Medical center; Methodology; Outcome; Participant; Pathologist; Patient Recruitments; Patients; Population; Population Heterogeneity; Procedures; Process; Protocols documentation; Questionnaires; Records; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk; Serological; Specimen; Standardization; System; Technology; Testing; Time; Translational Research; Virus; base; biobank; clinically relevant; cohort; cost efficient; data harmonization; data management; data sharing; design; digital; experience; fight against; follow-up; genetic linkage analysis; laboratory equipment; member; novel virus; pandemic disease; patient oriented; patient portal; programs; prospective; recruit; response; routine screening; sample collection; user-friendly; virtual

PROJECT SUMMARY/ABSTRACT for the Recruitment and BioBanking Core The Recruitment and Biobanking Core (RBC) will serve as a Resource Support Core for 3 full Research Projects. This core provides a standardized system for patient identification and recruitment, longitudinal follow- up using active and passive methodologies, biospecimen collection, tracking, processing, storage, and distribution; access to state-of-the-art laboratory technologies provided in Core 2; linkage to medical records and other relevant external databases; computational and statistical support; and enables future research in collaboration with SeroNET and beyond. Importantly, this core leverages already implemented cutting-edge initiatives underway at Cedars-Sinai, namely: (1) Biobanking Research Protocol that universally permits patients to participate in research by utilizing and storing their biospecimens and conducting follow-up procedures for research purposes; (2) Cedars-Sinai Accelerator which has funded start-up companies (e.g., Hawthorne Effect) to develop and implement integrated technological platforms to provide timely, accurate data from patients as well as networks to facilitate remote data and biospecimens collections; and (3) Cedars-Sinai’s Employee Cohort that has conducted timely repeated questionnaire assessments, repeated biospecimen collection and repeated SARS-CoV-2 testing on >6,000 Essential Health Care Workers. The RBC will merge these activities into a centralized approach with the following goals: 1. Expand Recruitment and Prospective Follow-Up: Cedars-Sinai COVID-19 Risk Associations and Longitudinal Evaluation (CORALE) study leverages the expansive Cedars- Sinai network including two large medical centers and multiple outpatient clinics. The fully integrated Epic based electronic health record (EHR), known as CS-Link, allows for rapid connection with over >1M individuals and permits digital enrollment, consent and data entry and tracking via a virtual patient portal. Cedars-Sinai’s diverse catchment area in central Los Angeles allows a unique opportunity, unparalleled in other parts of the U.S., to bring together large diverse populations (including large numbers of Hispanics/Latinos and African Americans). Electronic communication, data entry and remote biospecimen collection capabilities enable rapid and cost- efficient longitudinal follow-up. 2. Biospecimen Collection, Processing and Storage: We will collect, process, store, and track all biospecimens using LabvantageTM, a user-friendly laboratory tracking system already implemented and supported directly by the Cedars-Sinai Biobank and Translational Research Core Laboratory. 3. Data Management, Linkage and Analyses: We will link demographic, clinical, epidemiologic, and outcomes data from our centralized EHR with the biospecimens and participant reported data. Our bioinformatic and computational shared resources will provide analytical support. 4. Expand Capacities for Future Research: We will provide access to state-of-the-art technologies available through the integration of our Core with our existing Shared Resources and enable data sharing with internal and external investigators in SeroNET.

招聘和生物库核心的项目摘要/摘要 招聘和生物库核心（RBC）将作为3个完整研究的资源支持核心 项目。该核心为患者识别和招聘，纵向跟随 - 提供了标准化系统 - 使用主动和被动的方法，生物循环收集，跟踪，处理，存储和 分配;访问Core 2中提供的最先进的实验室技术；与医疗记录的联系， 其他相关的外部数据库；计算和统计支持；并实现未来的研究 与Seronet及以后的合作。重要的是，这种核心利用已经实施了尖端 Cedars-Sinai的举措，即：（1）普遍允许患者的生物群研究方案 通过使用和存储其生物测量并进行后续程序来参与研究 研究目的； （2）资助初创公司的Cedars-Sinai加速器（例如，霍桑效应） 开发和实施集成的技术平台，以提供患者的及时准确数据 以及促进远程数据和生物测量收集的网络； （3）Cedars-Sinai的员工队列 这已经进行了及时重复的问卷评估，重复的生物测量收集并重复 SARS-COV-2对> 6,000名基本医疗保健工作者进行测试。加拿大皇家银行将将这些活动合并为 集中式方法具有以下目标：1。扩大招聘和潜在的随访：Cedars-Sinai COVID-199风险关联和纵向评估（Corale）研究利用了额外的雪松 - 西奈网络包括两个大型医疗中心和多个门诊诊所。完全集成的史诗 电子健康记录（EHR），称为CS-LINK，允许与超过1M的个人快速联系，并且 允许通过虚拟患者门户网站进行数字注册，同意和数据输入以及跟踪。雪松西奈的多样化 洛杉矶中部的集水区允许在美国其他地区无与伦比的独特机会， 将大量的潜水员人口汇集在一起​​（包括大量西班牙裔/拉丁裔和非裔美国人）。 电子通信，数据输入和远程生物传播收集功能使快速和成本 - 有效的纵向随访。 2。生物循环收集，处理和存储：我们将收集，处理， 商店，并使用Labvantagetm跟踪所有Bioscimens，这是一种用户友好的实验室跟踪系统 由Cedars-Sinai Biobank和Translational Research核心实验室直接实施和支持。 3。数据管理，链接和分析：我们将链接人群，临床，流行病学和结果 来自我们集中式EHR的数据和参与报告的数据。我们的生物信息学和 计算共享资源将提供分析支持。 4。扩大未来研究的能力：我们 将通过将我们的核心与现有的核心集成到现有 共享资源，并与Seronet中的内部和外部调查人员启用数据共享。