Neurobiology of avoidant/restrictive eating in youth

青少年回避/限制性饮食的神经生物学

基本信息

批准号：
10210232
负责人：
Elizabeth Austen Lawson
金额：
$ 19.22万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10210232
关键词：
Acute Amygdaloid structure Appetite Stimulants Arousal Award Behavioral Biological Markers Brain Brain imaging Brain-Derived Neurotrophic Factor Categories Cell Nucleus Choking Cholecystokinin Clinical Clinical Investigator Clinical Research Consumption Desire for food Dimensions Discipline Doctor of Medicine Eating Eating Behavior Eating Disorders Endocrine Endocrinology Environment Faculty Food Foundations Fright Functional disorder Funding Future Galvanic Skin Response General Hospitals Goals Grant Healthcare Heart Rate Homeostasis Hormones Human Hydrocortisone Hypothalamic structure Image Institution Insula of Reil Leadership Link Literature Magnetic Resonance Imaging Massachusetts Medial Medicine Mentors Methods Mid-Career Clinical Scientist Award (K24)Mission Modeling Multimodal Imaging National Institute of Mental Health Negative Valence Neurobiology Oxytocin Pathway interactions Peer Review Grants Perception Phenotype Psychiatry Psychology Publications Research Research Domain Criteria Research Personnel Research Project Grants Research Support Resistance Resources Sensory Structure Taste Perception Techniques Thalamic structure Time Training United States National Institutes of Health Vomiting Weight Work Youth base behavioral outcome biophysical properties brain abnormalities career cognitive system experience ghrelin gray matter hormonal signals imaging biomarker innovation median forebrain bundle medical schools mid-career faculty multidisciplinary multimodality neurobiological mechanism neuroimaging novel patient oriented research programs psychologic response restrictive eating stria terminalis three-dimensional modeling training opportunity trait white matter

项目摘要

Project Summary/Abstract The applicant, Elizabeth A. Lawson, M.D., M.M.Sc., is a practicing neuroendocrinologist at Massachusetts General Hospital and Associate Professor of Medicine at Harvard Medical School. Over the last decade Dr. Lawson’s research has focused on the link between hormone signaling, brain functioning, psychology and eating behavior in humans across a spectrum of weights and eating disorders. Her successful mentoring experience, publication and funding record demonstrate her commitment and passion for patient-oriented research and provide an excellent foundation to accomplish the goals and objectives of the K24 Award. The specific aims are: 1) To enable Dr. Lawson to dedicate time to mentor junior clinical investigators based on her already NIH funded R01 grant on neurobiological underpinnings of avoidant/restrictive eating; 2) To mentor residents, fellows, and junior faculty from Psychiatry, Endocrinology, and other fields at MGH and across institutions with the goal of developing them into clinical investigators who can successfully compete for peer- reviewed grants related to the NIMH mission; and 3) To enable Dr. Lawson to further establish a patient- oriented research program that uses innovative multidisciplinary techniques to investigate the neurobiology underlying eating behaviors, and that provides an ideal environment to develop future leaders in clinical research. The training environment is outstanding in terms of didactic resources and availability of techniques to assess cross-disciplinary endpoints. Importantly, Dr. Lawson has the strong commitment from leadership of both Endocrinology and Psychiatry who have enthusiastically endorsed her research program, mentoring, and K24 proposal. The specific research aims of the application are based on a recently funded R01 investigating the link between hormones, brain function and clinical features in youth with avoidant/restrictive eating. Important new directions will include multimodal neuroimaging, including assessment of brain structure (gray matter volume and white matter connectivity) and relationship with functional brain abnormalities and clinical features.

项目概要/摘要申请人伊丽莎白·A·劳森 (Elizabeth A. Lawson)，医学博士、理学硕士，是马萨诸塞州的一名执业神经内分泌学家过去十年，哈佛医学院综合医院医学副教授。劳森的研究重点是激素信号传导、大脑功能、心理学和她对不同体重和饮食失调的人类饮食行为进行了成功的指导。经验、出版物和资助记录显示了她对以患者为中心的承诺和热情研究并为实现 K24 奖的目的和目标提供良好的基础。具体目标是： 1) 让 Lawson 博士能够投入时间根据她的经验指导初级临床研究人员 NIH 已经资助了关于回避/限制性饮食的神经生物学基础的 R01 拨款 2) 指导；来自 MGH 及其他领域的精神病学、内分泌学和其他领域的住院医师、研究员和初级教师机构的目标是将他们培养成能够成功竞争同行的临床研究人员 3) 为了使劳森博士能够进一步建立患者- 使用创新的多学科技术来研究神经生物学的定向研究计划潜在的饮食行为，并为培养未来临床领导者提供了理想的环境研究的培训环境在教学资源和技术可用性方面非常出色。重要的是，劳森博士得到了领导层的坚定承诺。内分泌学和精神病学都热情支持她的研究计划、指导和 K24提案的具体研究目标基于最近资助的R01调查。回避/限制性饮食青少年的激素、大脑功能和临床特征之间的联系。重要的新方向将包括多模式神经影像学，包括大脑结构的评估（灰色物质体积和白质连接）以及与功能性大脑异常和临床的关系特征。