Administrative Core

行政核心

• 批准号: 10207345
• 负责人: Arlene H. Sharpe
• 金额: $ 37.75万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-05 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207345
• 关键词: Administrative Personnel; Animals; Applications Grants; Award; Bioinformatics; CRISPR screen; CRISPR/Cas technology; Caliber; Cells; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communication; Communities; Conflict (Psychology); Conflict of Interest; Data; Data Analyses; Ensure; Funding; Genetic Screening; Goals; Grant; Group Meetings; Guidelines; Hospitals; Human; Human Resources; Human Subject Research; Immunity; Individual; Infrastructure; Institutes; Institution; Lead; Leadership; Manuscripts; Mediating; Methods; Monitor; Online Systems; Pilot Projects; Preparation; Principal Investigator; Procedures; Process; Progress Reports; PubMed; Public Policy; Reporting; Research Personnel; Research Project Grants; Research Support; Resolution; Resource Sharing; Schedule; Scientist; Secure; Services; Structure; System; Teleconferences; Time; Travel; United States National Institutes of Health; Validation; acute infection; adaptive immune response; base; career; conflict resolution; data management; data portal; data sharing; in vivo; innovation; innovative technologies; medical schools; meetings; member; mouse model; novel; operation; organizational structure; programs; screening; success; web portal

The major objectives of the Administrative Core are to institute an infrastructure that facilitates productive interactions among the U19 Program investigators of this grant application, “Defining regulators of immunity to acute infection using CRISPR screens” and implements our Pilot Project program. The Administrative Core will serve as a centralized, transparent organizational structure to provide administrative support that enables the Principal investigators and their personnel to focus on their experimental and scientific goals. Dr. Sharpe, Program Director of the overall U19 grant, will provide leadership and direction for operations of the Administrative Core, which will be based at Harvard Medical School. Dr. Haining, Co-Director of this U19 grant and Core A, will lead the Pilot Grant Program. The Administrative Core will be responsible for carrying out the following functions: a) Provide the infrastructure for overall management and co-ordination; b) Facilitate and promote interactions and communication between program investigators, scientific advisors and administrative personnel; c) Plan and coordinate annual External Scientific Advisory Group (ESAG) meetings; d) Organize and coordinate travel for ESAG members; e) Assist the Program Directors and Principal Investigators with oversight of scientific, fiscal, regulatory and compliance matters, and with preparation and review of yearly progress reports and financial reports; f) Implement a plan for data management/sharing among investigators; and g) Implement the Pilot Project Program. The Administrative Core will also resolve all conflicts that may arise. To achieve these goals, Core A has the following specific aims: Aim 1: To provide infrastructure for overall management and coordination. Core A will provide administrative support and coordination to promote communication and interactions among Project and Core investigators, including the scheduling of regular teleconferences/face-to-face meetings and annual meetings, preparing and submitting annual progress reports, providing fiscal oversight and ensuring institutional compliance with fiscal, regulatory and scientific issues, and conflict resolution. Aim 2: To maintain a web-based portal for data sharing via a secure Dropbox. Core A will host and manage a secure Dropbox portal for data sharing within the U19. This easy access to data will maximize transparency, encourage collaboration, and aid in monitoring project progress and how collaborators are utilizing core services. Aim 3: To implement the Pilot Project Program. Core A will develop an effective process to solicit review and award high caliber innovative Pilot Projects that use our in vivo CRISPR platform, and monitor their progress. We will encourage applications from early career investigators. Through these specific Aims, we will create an Administrative Core structured to implement processes/procedures to enable the success of this highly collaborative program.

行政核心的主要对象是建立一个促进的基础架构 U19计划调查员之间的生产互动，“定义 使用CRISPR屏幕免疫对急性感染的监管机构”并实施了我们的试点项目 程序。行政核心将充当集中式的透明组织结构 提供行政支持，使主要调查员及其人员专注于 他们的实验和科学目标。整体U19 Grant计划主任Sharpe博士将 为行政核心的运营提供领导和指导，这将基于 哈佛医学院。 U19赠款和核心A的联合主任Haining博士将领导飞行员赠款 程序。行政核心将负责执行以下功能：a）提供 总体管理和协调的基础设施； b）促进和促进互动和 计划调查员，科学顾问和行政人员之间的沟通； c）计划 并协调年度外部科学咨询小组（ESAG）会议； d）组织和 协调ESAG成员的旅行； e）协助计划董事和主要调查员 监督科学，财政，监管和合规性事项，并准备和审查 年度进度报告和财务报告； f）实施数据管理/共享计划 调查人员； g）实施试点项目计划。行政核心也将解决所有 可能出现的冲突。为了实现这些目标，核心A具有以下特定目的：目标1： 为整体管理和协调提供基础架构。核心A将提供管理 支持和协调以促进项目和核心之间的沟通和互动 调查人员，包括定期电视会议/面对面会议的安排 会议，准备和提交年度进度报告，提供财政监督并确保 机构遵守财政，监管和科学问题以及解决冲突。目标2：到 通过安全的Dropbox维护基于Web的门户用于数据共享。核心A将主机和管理 一个安全的Dropbox门户，用于U19中的数据共享。轻松访问数据将最大化 透明度，鼓励协作并协助监视项目进度以及合作者如何 正在使用核心服务。目标3：实施试点项目计划。核心A将发展 征求审查并授予使用我们体内的高素质创新试点项目的有效过程 CRISPR平台，并监视他们的进度。我们将鼓励早期职业的申请 调查人员。通过这些特定目标，我们将创建一个构建到的管理核心 实施流程/程序，以使这个高度协作计划的成功。