Carolina Center on Alzheimer's Disease and Minority Research (CCADMR)

卡罗莱纳州阿尔茨海默病和少数民族研究中心 (CCADMR)

• 批准号: 10207460
• 负责人: Daniela B. Friedman
• 金额: $ 63.38万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207460
• 关键词: Address; African American; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Behavioral; Brain; Cardiovascular system; Centers for Disease Control and Prevention (U.S.); Cessation of life; Cognitive aging; Collaborations; Communities; Country; Data Analyses; Data Set; Death Rate; Diagnosis; Economically Deprived Population; Economics; Education; Elderly; Environmental Risk Factor; Faculty; Financial Hardship; Funding; Geography; Goals; Health; Health Services Accessibility; Historically Black Colleges and Universities; Home; Human; Infrastructure; Institution; Investments; Knowledge; Leadership; Medical; Mentors; Mentorship; Minority; Mission; Morbidity - disease rate; National Institute on Aging; Outcome; Personal Satisfaction; Population; Population Research; Positioning Attribute; Poverty; Prevalence; Principal Investigator; Public Health; Registries; Reporting; Research; Research Personnel; Role; Science; Scientist; South Carolina; Time; Training; Training Programs; Training and Education; Underrepresented Minority; United States; Universities; brain research; caucasian American; disadvantaged background; disease registry; education research; educationally disadvantaged; ethnic minority population; experience; health disparity; healthy aging; minority health; minority scientist; mortality; population based; population health; programs; racial minority; recruit; smart home; social; social culture; success; undergraduate research

OVERALL SECTION PROJECT SUMMARY/ABSTRACT Due to its tremendous human and financial burden, Alzheimer’s disease and related dementias (ADRD) have risen to the forefront of the United States (U.S.) public health agenda. Older African Americans are at an increased likelihood of having ADRD. South Carolina has the highest age-adjusted death rate from ADRD in the U.S. A better understanding of the role that sociocultural, behavioral, and environmental determinants have on ADRD outcomes among African-American communities in the Southeast is critically and immediately needed. The overall goal of the proposed Carolina Center on Alzheimer’s Disease and Minority Research (CCADMR) is to increase the diversity of the research workforce focused on population health and determinants of ADRD disparities through sustained infrastructure that will support underrepresented and minority (URM) faculty focused on the health and well-being of minority elders. The Specific Aims of the proposed AD-RCMAR are to: (1) increase the capacity of URM scholars to advance the science on the sociocultural, behavioral, and environmental factors that influence ADRD outcomes in order to reduce ADRD-related disparities, with a focus on African Americans, and (2) advance the science of ADRD research focused on population health and determinants of ADRD disparities through research education in population-based, secondary data analysis, interdisciplinary co-mentoring teams, well-established strategies for recruitment of AD-RCMAR Scientists, and education on Health Disparities and Minority Aging Research. The proposed CCADMR is a state-wide collaboration, providing mentorship and education on determinants of ADRD disparities using population-based datasets for URM faculty throughout South Carolina, at the three major research institutions, including University of South Carolina (UofSC), Medical University of South Carolina (MUSC), and Clemson University (CU), and three Historically Black Colleges and Universities (HBCUs), including Allen University, Claflin University, and South Carolina State University. Interdisciplinary and partner-engaged research, with which the principal investigators (PIs) and research team have expertise, will be an effective strategy for addressing ADRD-related disparities. The proposed Center leverages the multiple PIs’ extensive leadership in providing critical training in aging and ADRD for URM Scientists and their research expertise in cognitive aging, minority health, and ADRD disparities. The PIs and Core Leads are well-established and collaborative scholars with substantial mentoring experience and content knowledge that will contribute to the success of the proposed CCADMR.

整个部分 项目摘要/摘要 应得的巨大人力和经济负担，阿尔茨海默氏病和相关痴呆症 （ADRD）已升至美国（美国）公共卫生议程的最前沿 非裔美国人的可能性增加了南卡罗来纳州。 在美国，ADRD的年龄调整后的死亡率最高 社会文化，行为和环境决定因素对ADRD结果的决定因素 东南地区的非裔美国人社区至关重要，立即需要 阿尔茨海默氏病和少数族裔研究的支撑性卡罗来纳州中心的总体目标 （CCADMR）是为了增加专注于人口健康的研究劳动力的多样性 以及通过持续的基础设施来支持ADRD差异的决定因素 代表性不足和少数民族（URM）教师的重点是少数群体的健康和福祉 长者。 关于社会主义，行为和环境因素的科学学者 影响ADRD的结果以减少与ADRD相关的差距，重点是非洲 美国人，以及（2）ADRD研究的科学专注于人口健康和 通过在人口低音中进行研究教育的ADRD差距的决定因素 数据分析，跨学科的同学团队，建立良好的招聘策略 AD-RCMAR科学家以及有关健康差异和少数族裔老化研究的教育 支撑CCADMR是一项全州合作，提供指导和教育 使用基于人群的数据集的ADRD差异的决定因素，用于URM教师 南卡罗来纳州的三个主要研究机构，不属于南卡罗来纳大学 （UOFSC），南卡罗来纳州医科大学（MUSC）和克莱门顿大学（CU），三个 历史上黑色的集结和大学（HBCUS），包括艾伦大学，克拉夫林 跨学科和合作伙伴的研究。 首席研究人员（PIS）和研究团队具有专业知识，将是一个 解决ADRD相关差异的有效策略。 多个PI在为URM提供衰老和ADRD的重要培训方面的广泛领导 科学家和认知衰老，少数民族健康和ADRD不存在的研究专业知识。 PI和核心线索是建立良好和协作的学者 指导经验和内容知识将有助于拟议的成功 CCADMR。