Brain atrophy, cognitive impairment and Alzheimer's in low CVD-risk population

低心血管疾病风险人群中的脑萎缩、认知障碍和阿尔茨海默病

• 批准号: 10203685
• 负责人: CALEB E FINCH
• 金额: $ 103.59万
• 依托单位: CHAPMAN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10203685
• 关键词: 2019-nCoV; Administrative Supplement; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Bolivia; Bolivian; COVID-19; COVID-19 pandemic; Cardiovascular Diseases; Cognitive; Data; Dementia; Diet; Disease; Elderly; Epidemic; Funding; Genotype; Goals; Impaired cognition; Impairment; Incidence; Indigenous; Individual; Infection; Inflammation; Light; Longevity; Low Prevalence; Morbidity - disease rate; Neurologic; Parents; Phase; Physical activity; Population; Prevalence; Research; Risk; Virus Diseases; cardiovascular disorder risk; cerebral atrophy; cognitive function; cognitive testing; dementia risk; infection burden; inflammatory marker; mortality; neuroimaging

Project Summary The parent RF1 (1 RF1 AG054442-01) provides new data on brain atrophy and Alzheimer’s disease and Related Dementias (ADRD) in two indigenous Bolivian populations, the Tsimane and the Moseten, with extremely low rates of cardiovascular disease (CVD) but high burdens of infection and inflammation. The aims of this project are: (1) Longitudinal assessment of cognitive impairment and dementia in a low cardiovascular disease (CVD) risk population, Tsimane forager-horticulturalists of lowland Bolivia; (2) Neuroimaging to identify brain atrophy correlates of cognitive impairment, AD and other dementias; (3) Characterization of the prevalence of brain atrophy, cognitive impairment, and dementias in the Tsimane; (4) Collect in- depth data on diet and physical activity; and (5) Examine the interaction of inflammation and APOE genotype on cognitive functioning for individual longitudinal change. ADRD prevalence was estimated during the first 2.5 years of NIA funding. Current results indicate a low prevalence (<5%) of dementia after age 70 with no cases of moderate to severe dementia. The two specific aims of this administrative supplement will determine: (1) whether cognitive impairment and dementia are risk factors for SARS-CoV-2 infection and/or morbidity and mortality, if infected; and (2) if Covid-19 results cognitive and neurological aging impairment. The first aim is necessary for interpreting existing data and achieving the original project goals. it is necessary to determine whether those who develop cognitive impairment dementia are at greater risk for COVID-19 mortality in order to control for a potential downward bias in the estimation of dementia incidence. The second aim presents a new unique opportunity to investigate the original project goal of studying impacts of infection on cognitive decline and ADRD. It will evaluate the impact of COVID-19 infection on cognitive function and ADRD incidence.

项目摘要 家长RF1（1 RF1 AG054442-01）提供了有关脑萎缩和阿尔茨海默氏症的新数据 疾病和相关痴呆症（ADRD）在两个土著玻利维亚人群中 和埃斯汀，心血管疾病（CVD）的发生率极低，但高燃烧 感染和炎症。该项目的目的是：（1） 低心血管疾病（CVD）风险人群的认知障碍和痴呆症， 低地玻利维亚的西曼氏木觅食园艺主义者； （2）鉴定脑萎缩的神经影像学 认知障碍，AD和其他痴呆症的相关性； （3）表征 脑海中脑萎缩，认知障碍和痴呆症的患病率； （4）收集 饮食和体育锻炼的深度数据； （5）检查炎症和 针对单个纵向变化的认知功能的APOE基因型。 ADRD患病率 在NIA资金的前2。5年中进行了估计。当前结果表明低 70岁以后的痴呆症患病率（<5％），没有中度至重度痴呆症病例。 此行政补充的两个具体目标将确定：（1）认知是否是否 障碍和痴呆是SARS-COV-2感染和/或发病率的危险因素 死亡率，如果感染； （2）如果COVID-19会导致认知和神经衰老障碍。 第一个目的对于解释现有数据并实现原始项目目标是必要的。 有必要确定那些发展认知障碍痴呆症的人是否处于 COVID-19死亡率的更大风险是为了控制潜在的向下偏见 痴呆事件的估计。第二个目标为新的独特机会提供了 研究研究感染对认知能力下降和 adrd。它将评估Covid-19感染对认知功能和ADRD的影响 发病率。

项目成果

Methodological differences cannot explain associations between health, anthropometrics, and excess resting metabolic rate.

方法学差异无法解释健康、人体测量学和过量静息代谢率之间的关联。

• DOI: 10.1002/ajpa.23811
• 发表时间: 2019
• 期刊: American journal of physical anthropology
• 影响因子: 2.8
• 作者: Gurven,Michael;Trumble,Benjamin;Stieglitz,Jonathan;Cummings,Dan;Kaplan,Hillard;Blackwell,AaronD;Yetish,Gandhi;Pontzer,Herman
• 通讯作者: Pontzer,Herman

Information transmission and the oral tradition: Evidence of a late-life service niche for Tsimane Amerindians.

信息传播和口头传统：提斯曼美洲印第安人晚年服务利基的证据。

• DOI: 10.1016/j.evolhumbehav.2017.10.006
• 发表时间: 2018
• 期刊: Evolution and human behavior : official journal of the Human Behavior and Evolution Society
• 作者: Schniter,Eric;Wilcox,NathanielT;Beheim,BretA;Kaplan,HillardS;Gurven,Michael
• 通讯作者: Gurven,Michael

Cultural variation in running techniques among non-industrial societies.

非工业社会中跑步技术的文化差异。

• DOI: 10.1017/ehs.2022.12
• 发表时间: 2022
• 期刊: Evolutionary human sciences
• 影响因子: 2.6
• 作者: Wallace,IanJ;Kraft,ThomasS;Venkataraman,VivekV;Davis,HelenE;Holowka,NicholasB;Harris,AlexandraR;Lieberman,DanielE;Gurven,Michael
• 通讯作者: Gurven,Michael

Natural selection of immune and metabolic genes associated with health in two lowland Bolivian populations.

• DOI: 10.1073/pnas.2207544120
• 发表时间: 2023-01-03
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1

Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists.

• DOI: 10.1002/alz.12626
• 发表时间: 2023-01
• 期刊: ALZHEIMERS & DEMENTIA
• 影响因子: 14
• 作者: Gatz, Margaret;Mack, Wendy J.;Chui, Helena C.;Law, E. Meng;Barisano, Giuseppe;Sutherland, M. Linda;Sutherland, James D.;Rodriguez, Daniel Eid;Gutierrez, Raul Quispe;Adrian, Juan Copajira;Cuata, Jesus Bani;Borenstein, Amy R.;Walters, Ellen E.;Irimia, Andrei;Rowan, Christopher J.;Wann, L. Samuel;Allam, Adel H.;Thompson, Randall C.;Miyamoto, Michael, I;Michalik, David E.;Cummings, Daniel K.;Seabright, Edmond;Garcia, Angela R.;Hooper, Paul L.;Kraft, Thomas S.;Finch, Caleb E.;Thomas, Gregory S.;Stieglitz, Jonathan;Trumble, Benjamin C.;Gurven, Michael D.;Kaplan, Hillard
• 通讯作者: Kaplan, Hillard