Research Training in Pulmonary Immunology and Allergy at MGH

MGH 肺部免疫学和过敏研究培训

• 批准号: 10202695
• 负责人: David C Christiani
• 金额: $ 67.84万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202695
• 关键词: Hypersensitivity; Immunology; Lung; Research Training

Research Training in Pulmonary Immunology and Allergy at MGH is a T32 renewal application that brings together research programs of the Massachusetts General Hospital (MGH) Division of Pulmonary and Critical Care Medicine (DPCCM), Allergy and Clinical Immunology Unit (ACIU), and Center for Immunology and Inflammatory Diseases (CIID). This Training Program was created principally to provide comprehensive training for physician-scientists in the DPCCM and ACIU fellowship programs interested in lung immunology and allergic inflammation. The Program is designed to prepare the next generations of physician-scientists and PhD-scientists to be leaders in lung immunology and allergy related research. In the first 3.5 years, this Program has been highly successful with no unfilled slots and 100% academic retention. In addition, all of the graduates of the Program have published at least one first-author publication and 73% have secured independent funding. In this renewal application we capitalize on this success and momentum and provide training in 10 scientific disciplines: (i) Adaptive Lung Immunity; (ii) Innate Lung Immunity; (iii) Allergic Sensitization, Tolerance & Immunodeficiency; (iv) Lung Injury, Repair & Regeneration; (v) Molecular Epidemiology & Genetics of Lung Disease and Allergy; (vi) Health Care Delivery Science in Pulmonary and Allergy; (vii) Translational & Precision Medicine; (viii) Systems Biology, Single Cell Genomics & Epigenetics; (ix) Microbiome; (x) Novel Imaging Modalities. The Program will have basic, translational, health outcomes and epidemiology components. Specifically we seek to provide: 1) opportunities for mentored research in disciplines that have the potential for high-impact discoveries; 2) outstanding research training through didactics, seminars, and comprehensive mentoring; and 3) an environment and infrastructure that fosters scholarly activity and career development into independent scientists. This application requests 10 training positions that will be allocated to trainees who are committed to 2 to 3 years of research training. Eight MD or MD/PhD candidates will be drawn from the highly competitive DPCCM and ACIU fellowship programs. Two PhD trainees will be chosen from postdoctoral fellows in the laboratories of our mentors who are performing at a high level and who have demonstrated a commitment to careers in pulmonary or allergy research. Two new slots for PhD trainees are being requested based on trainee and mentor feedback indicating that our Program would be strengthened, and the mission of the NIH better served, by having MDs and PhDs train side-by-side. The 28 mentors in this Program were carefully chosen based on their track record of publications, grants, mentoring, collaboration and interest in lung immunology and allergy. MGH provides an outstanding training environment with over 1400 investigators, numerous training grants, research centers, trainee support groups, and over $850 million in research grant awards. Furthermore, opportunities at Harvard Medical School, the Harvard School of Public Health, and the Broad Institute provide additional valuable resources for trainees.

MGH 的肺免疫学和过敏研究培训是 T32 更新应用程序，它带来了 马萨诸塞州总医院 (MGH) 肺科和重症科的共同研究项目 护理医学 (DPCCM)、过敏和临床免疫学单位 (ACIU) 以及免疫学和免疫学中心 炎症性疾病（CIID）。该培训计划的创建主要是为了提供全面的 为 DPCCM 和 ACIU 奖学金项目中对肺免疫学感兴趣的医师科学家提供培训 和过敏性炎症。该计划旨在培养下一代医师科学家和 博士科学家将成为肺免疫学和过敏相关研究的领导者。在最初的 3.5 年里， 该计划非常成功，没有空缺名额，并且学业保留率为 100%。此外，所有的 该项目的毕业生发表了至少一篇第一作者出版物，并且 73% 的毕业生已获得 独立资助。在此更新应用程序中，我们利用这一成功和势头，并提供 10 个科学学科的培训： (i) 适应性肺免疫； (ii) 肺部先天免疫力； (三) 过敏 致敏、耐受和免疫缺陷； (iv) 肺损伤、修复与再生； (v) 分子 肺部疾病和过敏的流行病学和遗传学； (vi) 肺和疾病领域的医疗保健提供科学 过敏; (vii) 转化医学和精准医学； (viii) 系统生物学、单细胞基因组学和表观遗传学； (九) 微生物组； (x) 新颖的成像方式。该计划将具有基本的、转化的、健康的成果和 流行病学成分。具体来说，我们寻求提供：1）指导研究的机会 具有产生高影响力发现潜力的学科； 2) 杰出的研究培训 教学、研讨会和综合指导； 3) 促进发展的环境和基础设施 学术活动和职业发展成为独立科学家。此应用程序需要 10 次训练 将分配给致力于 2 至 3 年研究培训的学员的职位。八个医学博士或 医学博士/博士候选人将从竞争激烈的 DPCCM 和 ACIU 奖学金计划中选拔。二 博士生将从我们导师实验室的博士后研究员中选拔，他们在 高水平并表现出对肺部或过敏研究职业的承诺。两个新 根据实习生和导师的反馈，我们正在申请博士实习生的名额，表明我们的计划 通过让医学博士和博士并肩训练，NIH 的使命将会得到加强，并更好地服务于国家卫生研究院的使命。 该计划的 28 名导师是根据他们的出版物、资助、 对肺免疫学和过敏的指导、合作和兴趣。 MGH 提供出色的培训 拥有 1400 多名研究人员、大量培训补助金、研究中心、实习生支持小组的环境， 以及超过 8.5 亿美元的研究补助金。此外，哈佛医学院的机会 哈佛大学公共卫生学院和布罗德研究所为学员提供了额外的宝贵资源。