Elucidating the neural mechanisms behind transcranial direct current stimulation

阐明经颅直流电刺激背后的神经机制

基本信息

批准号：
10203808
负责人：
MYLES Mc Laughlin
金额：
$ 20.92万
依托单位：
KATHOLIEKE UNIVERSITEIT LEUVEN
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10203808
关键词：
Affect Anesthetics Animal Experiments Animals Automobile Driving Behavioral Brain Cell Nucleus Cervical nerves Clinical Trials Cognitive Communication Cranial Nerves Cream Development Devices Effectiveness Electrodes Electrophysiology (science)Funding Human Human Resources Impaired cognition Investigation Knowledge Lead Learning Marketing Medical Membrane Memory Mental Depression Mental disorders Methods Monitor Motor Motor Cortex Motor Evoked Potentials Nature Nervous System control Neurons Norepinephrine Peripheral Nerve Stimulation Peripheral Nerves Pharmacology Positioning Attribute Publications Rattus Reporting Reproducibility Resources Role Route Sales Scalp structure Schizophrenia Series Shock Sympathetic Nervous System Synaptic plasticity Testing Time Trigeminal nerve structure Work addiction compare effectiveness cranium effectiveness evaluation electric field empowered experience experimental study healthy volunteer improved insight locus ceruleus structure mild cognitive impairment motor learning nervous system disorder neuromechanism neurophysiology neuroregulation novel relating to nervous system skills transcutaneous stimulation

项目摘要

PROJECT SUMMARY/ABSTRACT Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulation method in which direct current is passed through scalp electrodes. The current flows through the scalp, skull and CSF before creating a weak electric field in the brain and causing membrane polarization in cortical neurons. Over the last 20 years, thousands of studies have highlighted many wide ranging tDCS effects on perceptual, cognitive and motor function. More recently, clinical trials have begun to assess the effectiveness of tDCS in treating mental illnesses such as addiction, depression and schizophrenia. However, in spite of the massive amount of financial and scientific resources directed towards tDCS, there is considerable debate about its effectiveness and reproducibility. Perhaps even more surprisingly, the basic mechanism though which tDCS exerts these effects remains unknown. The aim of this project is to answer this fundamental question by elucidating and understanding the mechanisms driving the reported tDCS effects. In addition to the neuromodulatory effects caused by direct polarization of cortical neurons, tDCS also stimulates cranial and cervical nerves in the scalp that give indirect input to the brain. Potential effects from this indirect tDCS neuromodulatory route have been largely overlooked by the field. This project will combine healthy volunteer and animal experiments to investigate a range of potential tDCS mechanisms. Healthy volunteer’s experiments will use careful controls and pharmacological blockers to probe the potential mechanisms that are driving tDCS effects. Animal electrophysiology experiments will be used to test the validity of and to provide insight into these mechanisms. Given the current issues in the tDCS field, the deeper mechanistic insight provided by this project will be vital in advancing the tDCS field at this critical juncture. The new insight provided by this project will help direct financial and scientific resources towards the development of improved noninvasive neuromodulation therapies, which can then more effectively treat a wide range of neurological and psychiatric disorders.

项目摘要/摘要经颅直流刺激（TDC）是一种无创神经调节方法，其中直接电流通过头皮电极。在大脑中产生弱电场，并在皮质神经元中引起膜极化。最近20年，成千上万的研究突出了许多广泛的TDC对感知，认知的影响 Ando运动功能。最近，临床试验已经开始评估诸如添加的精神疾病，因为深度和学校。关于TDC的财务和科学资源，有关其的辩论很大有效性和繁殖。这些效果仍然未知。阐明和理解corted tdcs效应的机制。由皮质神经元直接极化引起的神经调节作用，TDC还刺激颅骨头皮中的宫颈神经对大脑的潜在影响。神经调节路线被该项目忽略了。动物实验研究了一系列潜在的TDC机制经验将控制和药理学阻滞剂，以探测潜在的机制正在驱动TDCS效应。提供有关机制的洞察力。时间项目提供的洞察力对于在此批评中推进TDCS领域至关重要该项目与地狱直升机财务和科学资源一起为发展而发展无创神经调节疗法可以有效地处理广泛的神经病学 Andychiatric疾病。